| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Eagle Eye | - | - | - | $101,440,743 | 3,614 | $29,150,721 | 28.7% | 3,510 | Sep 26 | Jan 8 | DreamWorks | false |
| 2 | Burn After Reading | - | - | - | $60,355,347 | 2,657 | $19,128,001 | 31.7% | 2,651 | Sep 12 | Dec 25 | Focus Features | false |
| 3 | Nights in Rodanthe | - | - | - | $41,850,659 | 2,704 | $13,418,454 | 32.1% | 2,704 | Sep 26 | Jan 15 | Warner Bros. | false |
| 4 | Righteous Kill | - | - | - | $40,081,410 | 3,152 | $16,288,361 | 40.6% | 3,152 | Sep 12 | - | Overture Films | false |
| 5 | Lakeview Terrace | - | - | - | $39,263,506 | 2,574 | $15,004,672 | 38.2% | 2,464 | Sep 19 | Nov 2 | Screen Gems | false |
| 6 | The Family That Preys | - | - | - | $37,105,289 | 2,070 | $17,381,218 | 46.8% | 2,070 | Sep 12 | Oct 23 | Lionsgate | false |
| 7 | Fireproof | - | - | - | $33,456,317 | 905 | $6,836,036 | 20.4% | 839 | Sep 26 | Jan 29 | The Samuel Goldwyn Company | false |
| 8 | The Women | - | - | - | $26,902,075 | 2,995 | $10,115,210 | 37.6% | 2,962 | Sep 12 | Nov 20 | Picturehouse | false |
| 9 | Appaloosa | - | - | - | $20,211,394 | 1,290 | $248,847 | 1.2% | 14 | Sep 19 | Jan 22 | Warner Bros. | false |
| 10 | Igor | - | - | - | $19,528,602 | 2,341 | $7,803,347 | 40% | 2,339 | Sep 19 | Jan 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 11 | My Best Friend's Girl | - | - | - | $19,219,250 | 2,636 | $8,265,357 | 43% | 2,604 | Sep 19 | Oct 23 | Lionsgate | false |
| 12 | Bangkok Dangerous | - | - | - | $15,298,133 | 2,654 | $7,783,266 | 50.9% | 2,650 | Sep 5 | Oct 23 | Lionsgate | false |
| 13 | The Duchess | - | - | - | $13,848,978 | 1,207 | $190,426 | 1.4% | 7 | Sep 19 | Dec 11 | Paramount Vantage | false |
| 14 | Ghost Town | - | - | - | $13,367,624 | 1,512 | $5,012,315 | 37.5% | 1,505 | Sep 19 | Nov 13 | DreamWorks | false |
| 15 | Miracle at St. Anna | - | - | - | $7,919,117 | 1,185 | $3,477,996 | 43.9% | 1,185 | Sep 26 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 16 | Choke | - | - | - | $2,926,565 | 435 | $1,319,286 | 45.1% | 435 | Sep 26 | Nov 23 | Fox Searchlight Pictures | false |
| 17 | Forever Strong | - | - | - | $719,556 | 259 | - | - | - | Sep 19 | Nov 9 | Crane Movie Company | false |
| 18 | A Secret | - | - | - | $623,558 | 11 | $37,135 | 6% | 3 | Sep 5 | May 7 | Strand Releasing | false |
| 19 | Towelhead | - | - | - | $372,124 | 100 | $52,823 | 14.2% | 4 | Sep 12 | Oct 23 | Warner Independent Pictures (WIP) | false |
| 20 | Everybody Wants to Be Italian | - | - | - | $351,416 | 98 | $197,861 | 56.3% | 98 | Sep 5 | Oct 16 | Roadside Attractions | false |
| 21 | The Lucky Ones | - | - | - | $266,967 | 425 | $183,088 | 68.6% | 425 | Sep 26 | Oct 2 | Lionsgate | false |
| 22 | Enlighten Up! | - | - | - | $246,649 | 12 | $11,799 | 4.8% | 1 | Sep 12 | Jun 28 | Balcony Releasing | false |
| 23 | Battle in Seattle | - | - | - | $224,169 | 40 | $46,903 | 20.9% | 8 | Sep 19 | Dec 7 | Redwood Palms Pictures | false |
| 24 | Mera Pind: My Home | - | - | - | $176,976 | 19 | $176,976 | 100% | 19 | Sep 5 | Sep 7 | Adlabs Films | false |
| 25 | Hounddog | - | - | - | $131,961 | 11 | $13,744 | 10.4% | 11 | Sep 19 | Dec 17 | Empire Pictures Inc. | false |
| 26 | Proud American | - | - | - | $131,357 | 750 | $135,000 | - | 750 | Sep 12 | Sep 21 | Slowhand Cinema Releasing | true |
| 27 | Greetings from the Shore | - | - | - | $96,314 | 31 | $40,527 | 42.1% | 31 | Sep 12 | Oct 23 | Freestyle Releasing | false |
| 28 | The Pool | - | - | - | $95,102 | 8 | $7,736 | 8.1% | 1 | Sep 3 | Dec 4 | Vitagraph Films | false |
| 29 | Save Me | - | - | - | $83,397 | 5 | $6,992 | 8.4% | 1 | Sep 5 | Jan 22 | First Run | false |
| 30 | Humboldt County | - | - | - | $82,357 | 9 | $25,933 | 31.5% | 9 | Sep 26 | Nov 6 | Magnolia Pictures | false |
| 31 | Ping Pong Playa | - | - | - | $77,907 | 14 | $30,797 | 39.5% | 9 | Sep 5 | Oct 9 | IFC Films | false |
| 32 | A Thousand Years of Good Prayers | - | - | - | $76,806 | 7 | $10,321 | 13.4% | 2 | Sep 19 | Oct 30 | Magnolia Pictures | false |
| 33 | August Evening | - | - | - | $74,759 | 4 | $3,296 | 4.4% | 1 | Sep 5 | Jan 8 | Maya Entertainment | false |
| 34 | Hallam Foe | - | - | - | $60,641 | 6 | $13,490 | 22.2% | 2 | Sep 5 | Oct 23 | Magnolia Pictures | false |
| 35 | Boogie Man: The Lee Atwater Story | - | - | - | $60,332 | 10 | $10,939 | 18.1% | 2 | Sep 26 | Nov 9 | InterPositive Media | false |
| 36 | Surfer, Dude | - | - | - | $52,132 | 69 | $5,971 | 11.5% | 1 | Sep 5 | Sep 21 | Anchor Bay Films | false |
| 37 | All Roads Lead Home | - | - | - | $43,907 | 46 | $31,785 | 72.4% | 46 | Sep 26 | Oct 9 | Waldo West Productions | false |
| 38 | Moving Midway | - | - | - | $40,864 | 4 | $6,539 | 16% | 2 | Sep 12 | Jan 1 | First Run | false |
| 39 | Loins of Punjab Presents | - | - | - | $39,891 | 8 | $14,850 | 37.2% | 4 | Sep 12 | Nov 9 | Emerging Pictures | false |
| 40 | Walking on Dead Fish | - | - | - | $30,328 | 4 | $10,524 | 34.7% | 1 | Sep 19 | Nov 13 | Variance Films | false |
| 41 | Shoot the Piano Player | - | - | - | $20,615 | 1 | $10,466 | 50.8% | 1 | Sep 5 | Sep 11 | Janus Films | false |
| 42 | Jake's Corner | - | - | - | $12,522 | 8 | $12,522 | 100% | 8 | Sep 5 | Sep 7 | Emerging Pictures | false |
| 43 | Whaledreamers | - | - | - | $10,584 | 6 | $1,827 | 17.3% | 6 | Sep 26 | Dec 7 | Monterey Media | false |
| 44 | Elite Squad | - | - | - | $8,744 | 1 | $3,604 | 41.2% | 1 | Sep 19 | Oct 2 | IFC Films | false |
| 45 | Amexicano | - | - | - | $8,655 | 1 | $2,746 | 31.7% | 1 | Sep 19 | Dec 18 | Maya Entertainment | false |
| 46 | Fraulein | - | - | - | $5,715 | 1 | $2,449 | 42.9% | 1 | Sep 19 | Oct 30 | Film Movement | false |
| 47 | The Amazing Truth About Queen Raquela | - | - | - | $5,597 | 2 | $2,700 | 48.2% | 2 | Sep 26 | Jun 25 | Regent Releasing | false |
