| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Kung Fu Panda | - | - | - | $16,992,693 | 669 | $22,037,818 | Aug 29 | Universal Pictures International (UPI) | false |
| 2 | Hancock | - | - | - | $16,352,179 | 678 | $17,819,261 | Sep 12 | Sony Pictures Releasing | false |
| 3 | Burn After Reading | - | - | - | $5,477,516 | 421 | $8,734,151 | Sep 19 | Medusa Distribuzione | false |
| 4 | A Perfect Day | - | - | - | $4,152,057 | 403 | $4,212,962 | Sep 5 | 01 Distribution | false |
| 5 | Giovanna's Father | - | - | - | $3,942,958 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 6 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $3,160,495 | 466 | $7,983,188 | Sep 26 | Universal Pictures International (UPI) | false |
| 7 | The Chronicles of Narnia: Prince Caspian | - | - | - | $2,069,310 | 601 | $10,800,873 | Aug 14 | Walt Disney Pictures | false |
| 8 | Gomorrah | - | - | - | $2,056,450 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 9 | The X Files: I Want to Believe | - | - | - | $1,814,021 | 332 | $2,003,812 | Sep 5 | 20th Century Fox International | false |
| 10 | Mid-August Lunch | - | - | - | $1,728,574 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 11 | Virgin Territory | - | - | - | $1,618,868 | 175 | $1,567,471 | Sep 5 | Eagle Pictures | false |
| 12 | Righteous Kill | - | - | - | $1,571,104 | 362 | $4,578,190 | Sep 26 | 01 Distribution | false |
| 13 | Il Divo | - | - | - | $1,516,199 | 358 | $8,517,653 | May 28 | Lucky Red | false |
| 14 | The X Files | - | - | - | $1,449,980 | 1 | $3,637,324 | Oct 30 | 20th Century Fox International | false |
| 15 | The Seed of Discord | - | - | - | $1,434,546 | 216 | $1,492,100 | Sep 5 | Medusa Distribuzione | false |
| 16 | Doomsday | - | - | - | $853,235 | 203 | $1,413,511 | Aug 29 | Medusa Distribuzione | false |
| 17 | Everyone's Hero | - | - | - | $478,508 | 139 | $483,144 | Sep 12 | Medusa Distribuzione | false |
| 18 | Star Wars: The Clone Wars | - | - | - | $441,175 | 198 | $453,441 | Sep 19 | Warner Bros. | false |
| 19 | Fireflies in the Garden 2008 Re-release | - | - | - | $435,435 | 174 | $910,176 | Sep 26 | Medusa Distribuzione | false |
| 20 | Meet Dave | - | - | - | $429,700 | 307 | $2,361,245 | Aug 22 | 20th Century Fox International | false |
| 21 | The Rocker | - | - | - | $368,974 | 149 | $426,236 | Sep 19 | 20th Century Fox International | false |
| 22 | Birdwatchers | - | - | - | $340,306 | 56 | $482,815 | Sep 2 | 01 Distribution | false |
| 23 | Deception | - | - | - | $339,581 | 208 | $664,207 | Aug 29 | Mikado Film | false |
| 24 | Shrooms | - | - | - | $302,141 | 111 | $1,143,622 | Aug 22 | Moviemax | false |
| 25 | Lorna's Silence | - | - | - | $255,015 | 39 | $525,788 | Sep 19 | Lucky Red | false |
| 26 | Leatherheads | - | - | - | $190,459 | 218 | $3,763,108 | Apr 11 | Universal Pictures International (UPI) | false |
| 27 | Paris | - | - | - | $182,602 | 65 | $695,130 | Sep 26 | BIM Distribuzione | false |
| 28 | Machan | - | - | - | $159,375 | 48 | $222,580 | Sep 12 | Mikado Film | false |
| 29 | Three Monkeys | - | - | - | $152,705 | 38 | $180,593 | Sep 12 | BIM Distribuzione | false |
| 30 | Pa-ra-da | - | - | - | $143,261 | 52 | $305,344 | Sep 19 | 01 Distribution | false |
| 31 | Taken | - | - | - | $133,232 | 198 | $2,091,060 | Aug 14 | 20th Century Fox International | false |
| 32 | La rabbia di Pasolini | - | - | - | $110,952 | 16 | $125,866 | Sep 5 | Istituto Luce | false |
| 33 | The Air I Breathe | - | - | - | $87,462 | 55 | $87,462 | Sep 5 | Warner Bros. | false |
| 34 | I Know Who Killed Me | - | - | - | $78,820 | 22 | $152,633 | Sep 5 | Moviemax | false |
| 35 | Reeker 2008 Re-release | - | - | - | $77,161 | 27 | $77,161 | Sep 5 | Mediafilm | false |
| 36 | Black Sheep | - | - | - | $39,546 | 23 | $39,546 | Sep 19 | Mediafilm | false |
| 37 | Teeth | - | - | - | $28,919 | 114 | $394,820 | Aug 22 | Mediafilm | false |
| 38 | Eldorado | - | - | - | $27,555 | 17 | $41,639 | Aug 29 | Archibald | false |
| 39 | The Wind Blows Round | - | - | - | $22,766 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 40 | The Girl by the Lake | - | - | - | $21,577 | 143 | $4,688,666 | Sep 14 | Medusa Distribuzione | false |
| 41 | Animanera | - | - | - | $19,053 | 34 | $43,106 | Aug 29 | Medusa Distribuzione | false |
| 42 | Billo - Il Grand Dakhaar | - | - | - | $16,421 | 3 | $26,106 | Sep 19 | - | false |
| 43 | La fabbrica dei tedeschi | - | - | - | $13,039 | 3 | $20,844 | Sep 12 | Istituto Luce | false |
| 44 | Redbelt | - | - | - | $10,465 | 10 | $10,465 | Sep 5 | Sony Pictures Releasing | false |
| 45 | The Kite Runner | - | - | - | $10,261 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 46 | 12 | - | - | - | $8,214 | 16 | $134,299 | Jun 27 | 01 Distribution | false |
| 47 | Caramel | - | - | - | $6,024 | 50 | $2,301,033 | Dec 21 | Archibald | false |
| 48 | Gravehopping | - | - | - | $5,993 | 2 | $43,057 | Jul 4 | - | false |
| 49 | La canarina assassinata | - | - | - | $5,368 | 2 | $8,434 | Sep 26 | - | false |
| 50 | The Hurt Locker | - | - | - | $4,927 | 70 | $234,231 | Oct 10 | Warner Bros. | false |
| 51 | Invincible 2008 Re-release | - | - | - | $4,586 | 3 | $30,473 | Jul 25 | Ripley's Film | false |
| 52 | Funny Games | - | - | - | $3,900 | 204 | $2,100,005 | Jul 11 | Lucky Red | false |
| 53 | Black and White | - | - | - | $1,699 | 301 | $8,096,913 | Jan 11 | 01 Distribution | false |
| 54 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $1,662 | 689 | $18,982,360 | May 23 | Universal Pictures International (UPI) | false |
| 55 | The Diving Bell and the Butterfly | - | - | - | $1,636 | 65 | $750,003 | Feb 15 | BIM Distribuzione | false |
| 56 | Ho ammazzato Berlusconi | - | - | - | $1,597 | 4 | $77,794 | Jun 20 | Independent Films | false |
| 57 | The Secret of the Grain | - | - | - | $1,553 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 58 | The Darjeeling Limited | - | - | - | $1,137 | 70 | $1,237,762 | Apr 30 | 20th Century Fox International | false |
| 59 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | - | - | - | $979 | 56 | $26,568 | Jul 4 | Mikado Film | false |
| 60 | Tutta la vita davanti | - | - | - | $976 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 61 | Shanghai Baby | - | - | - | $954 | 1 | $954 | Sep 19 | - | false |
| 62 | Quiet Chaos | - | - | - | $918 | 384 | $9,204,569 | Feb 8 | 01 Distribution | false |
| 63 | Non pensarci | - | - | - | $869 | 222 | $2,239,655 | Apr 4 | 01 Distribution | false |
| 64 | The Rest of the Night 2008 Re-release | - | - | - | $865 | 61 | $282,009 | Jun 11 | 01 Distribution | false |
| 65 | Noah's Ark | - | - | - | $796 | 233 | $1,056,897 | Oct 3 | Eagle Pictures | false |
| 66 | The Flock | - | - | - | $765 | 71 | $564,027 | Aug 14 | 01 Distribution | false |
| 67 | Go Go Tales | - | - | - | $762 | 110 | $849,766 | Jun 20 | Mediafilm | false |
| 68 | Woman's Hearts | - | - | - | $602 | 6 | $66,253 | Jun 13 | - | false |
| 69 | Juno | - | - | - | $595 | 239 | $3,352,339 | Apr 4 | 20th Century Fox International | false |
| 70 | Get Smart | - | - | - | $510 | 316 | $3,206,939 | Jul 9 | Warner Bros. | false |
| 71 | The Counterfeiters | - | - | - | $320 | 21 | $349,800 | Jan 25 | Lady Film | false |
| 72 | Mongol: The Rise of Genghis Khan | - | - | - | $302 | 137 | $1,325,000 | May 9 | BIM Distribuzione | false |
| 73 | Cassandra's Dream | - | - | - | $259 | 360 | $6,891,125 | Feb 1 | Filmauro | false |
| 74 | Star Wars: Episode III - Revenge of the Sith | - | - | - | $219 | 624 | $11,301,748 | May 20 | 20th Century Fox International | false |
| 75 | Untraceable | - | - | - | $208 | 56 | $353,014 | Aug 1 | 01 Distribution | false |
| 76 | Persepolis | - | - | - | $186 | 94 | $1,785,411 | Feb 22 | BIM Distribuzione | false |
| 77 | Paris, Dabar Undated Italy Release | - | - | - | $175 | 1 | $68,181 | - | - | false |
