| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $25,212,003 | 877 | $9,439,588 | 37.4% | 877 | Sep 13 | - | Buena Vista International | false |
| 2 | Superman Returns | - | - | - | $6,859,237 | 574 | $2,182,284 | 31.8% | 574 | Sep 1 | - | Warner Bros. | false |
| 3 | The Break-Up | - | - | - | $5,530,907 | 297 | $1,732,079 | 31.3% | 297 | Sep 22 | - | United International Pictures | false |
| 4 | Perfume: The Story of a Murderer | - | - | - | $3,639,053 | 335 | $1,049,469 | 28.8% | 335 | Sep 22 | - | Medusa Distribuzione | false |
| 5 | Golden Door | - | - | - | $3,257,977 | 122 | $371,685 | 11.4% | 110 | Sep 22 | - | 01 Distribution | false |
| 6 | Click | - | - | - | $3,187,895 | 194 | $885,687 | 27.8% | 194 | Sep 29 | - | Sony Pictures Releasing | false |
| 7 | The Black Dahlia | - | - | - | $2,822,578 | 318 | $1,079,985 | 38.3% | 318 | Sep 29 | - | 01 Distribution | false |
| 8 | The Missing Star | - | - | - | $2,723,863 | 267 | $683,779 | 25.1% | 262 | Sep 8 | - | 01 Distribution | false |
| 9 | The Queen | - | - | - | $2,682,560 | 191 | $803,680 | 30% | 191 | Sep 15 | - | BIM Distribuzione | false |
| 10 | Little Miss Sunshine | - | - | - | $2,039,673 | 68 | $164,606 | 8.1% | 68 | Sep 22 | - | 20th Century Fox International | false |
| 11 | Thank You for Smoking | - | - | - | $1,719,187 | 168 | $317,777 | 18.5% | 168 | Sep 1 | - | Lucky Red | false |
| 12 | Pulse | - | - | - | $1,283,648 | 219 | $482,541 | 37.6% | 219 | Sep 8 | - | Eagle Pictures | false |
| 13 | Lady in the Water | - | - | - | $1,067,315 | 174 | $472,610 | 44.3% | 174 | Sep 29 | - | Warner Bros. | false |
| 14 | The Stone Merchant | - | - | - | $1,029,807 | 215 | $482,086 | 46.8% | 215 | Sep 15 | - | Medusa Distribuzione | false |
| 15 | Baciami piccina | - | - | - | $632,826 | 170 | $270,227 | 42.7% | 170 | Sep 29 | - | Medusa Distribuzione | false |
| 16 | Stormbreaker | - | - | - | $466,419 | 231 | $282,532 | 60.6% | 231 | Sep 8 | - | Medusa Distribuzione | false |
| 17 | The Ant Bully | - | - | - | $349,807 | 147 | $164,549 | 47% | 147 | Sep 22 | - | Warner Bros. | false |
| 18 | As You Like It | - | - | - | $292,268 | 111 | $111,244 | 38.1% | 111 | Sep 1 | - | Medusa Distribuzione | false |
| 19 | A Good Woman | - | - | - | $230,250 | 68 | $89,940 | 39.1% | 68 | Sep 1 | - | 01 Distribution | false |
| 20 | Quinceañera | - | - | - | $218,184 | 28 | $46,394 | 21.3% | 23 | Sep 1 | - | Teodora Film | false |
| 21 | Clerks II | - | - | - | $215,369 | 115 | $117,685 | 54.6% | 115 | Sep 29 | - | Mikado Film | false |
| 22 | Dreamer | - | - | - | $197,933 | 128 | $111,373 | 56.3% | 128 | Sep 22 | - | Eagle Pictures | false |
| 23 | Belle toujours | - | - | - | $171,009 | 20 | $38,740 | 22.7% | 20 | Sep 8 | - | Mikado Film | false |
| 24 | DOA: Dead or Alive | - | - | - | $130,192 | 100 | $97,528 | 74.9% | 100 | Sep 8 | - | United International Pictures | false |
| 25 | The Road to Guantanamo | - | - | - | $118,887 | 38 | $59,130 | 49.7% | 38 | Sep 15 | - | Fandango | false |
| 26 | Snakes on a Plane | - | - | - | $84,356 | 105 | $84,356 | 100% | 105 | Sep 29 | - | Mediafilm | false |
| 27 | Friends with Money | - | - | - | $50,844 | 13 | $24,494 | 48.2% | 13 | Sep 8 | - | Sony Pictures Releasing | false |
| 28 | Five Fingers | - | - | - | $45,564 | 52 | $45,564 | 100% | 52 | Sep 8 | - | DNC Entertainment | false |
| 29 | What the Hell Am I Doing Here? | - | - | - | $39,854 | 34 | $22,585 | 56.7% | 34 | Sep 1 | - | Istituto Luce | false |
| 30 | The Orchestra of Piazza Vittorio | - | - | - | $34,385 | 8 | - | - | - | Sep 15 | - | Lucky Red | false |
| 31 | Crossing the Bridge: The Sound of Istanbul | - | - | - | $18,337 | 13 | $18,337 | 100% | 13 | Sep 1 | - | Fandango | false |
| 32 | Lettere dal Sahara | - | - | - | $15,258 | 6 | $15,258 | 100% | 6 | Sep 1 | - | Istituto Luce | false |
| 33 | Forget You Not | - | - | - | $14,052 | 20 | $14,052 | 100% | 20 | Sep 1 | - | Istituto Luce | false |
