| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $19,273,937 | 877 | $25,212,003 | Sep 13 | Buena Vista International | false |
| 2 | Cars | - | - | - | $8,384,008 | 637 | $16,456,342 | Aug 23 | Buena Vista International | false |
| 3 | Superman Returns | - | - | - | $6,046,763 | 574 | $6,859,237 | Sep 1 | Warner Bros. | false |
| 4 | The Break-Up | - | - | - | $3,535,896 | 297 | $5,530,907 | Sep 22 | United International Pictures | false |
| 5 | The Missing Star | - | - | - | $2,572,344 | 267 | $2,723,863 | Sep 8 | 01 Distribution | false |
| 6 | The Da Vinci Code | - | - | - | $2,505,929 | 910 | $39,197,477 | May 19 | Sony Pictures Releasing | false |
| 7 | Lucky Number Slevin | - | - | - | $2,494,449 | 304 | $4,486,090 | Aug 18 | Moviemax | false |
| 8 | Perfume: The Story of a Murderer | - | - | - | $2,333,594 | 335 | $3,639,053 | Sep 22 | Medusa Distribuzione | false |
| 9 | The Queen | - | - | - | $1,859,417 | 191 | $2,682,560 | Sep 15 | BIM Distribuzione | false |
| 10 | Thank You for Smoking | - | - | - | $1,520,188 | 168 | $1,719,187 | Sep 1 | Lucky Red | false |
| 11 | Pulse | - | - | - | $1,283,444 | 219 | $1,283,648 | Sep 8 | Eagle Pictures | false |
| 12 | The Black Dahlia | - | - | - | $1,079,985 | 318 | $2,822,578 | Sep 29 | 01 Distribution | false |
| 13 | The Stone Merchant | - | - | - | $984,776 | 215 | $1,029,807 | Sep 15 | Medusa Distribuzione | false |
| 14 | Garfield: A Tail of Two Kitties | - | - | - | $912,072 | 312 | $4,838,072 | Aug 18 | 20th Century Fox International | false |
| 15 | Golden Door | - | - | - | $904,777 | 122 | $3,257,977 | Sep 22 | 01 Distribution | false |
| 16 | Click | - | - | - | $885,687 | 194 | $3,187,895 | Sep 29 | Sony Pictures Releasing | false |
| 17 | The Hills Have Eyes | - | - | - | $587,901 | 249 | $1,589,032 | Aug 25 | 20th Century Fox International | false |
| 18 | Lady in the Water | - | - | - | $472,610 | 174 | $1,067,315 | Sep 29 | Warner Bros. | false |
| 19 | Stormbreaker | - | - | - | $466,419 | 231 | $466,419 | Sep 8 | Medusa Distribuzione | false |
| 20 | Little Miss Sunshine | - | - | - | $446,247 | 68 | $2,039,673 | Sep 22 | 20th Century Fox International | false |
| 21 | Little Man | - | - | - | $312,941 | 109 | $662,306 | Aug 25 | Sony Pictures Releasing | false |
| 22 | As You Like It | - | - | - | $292,268 | 111 | $292,268 | Sep 1 | Medusa Distribuzione | false |
| 23 | The Ant Bully | - | - | - | $288,296 | 147 | $349,807 | Sep 22 | Warner Bros. | false |
| 24 | Baciami piccina | - | - | - | $270,227 | 170 | $632,826 | Sep 29 | Medusa Distribuzione | false |
| 25 | A Good Woman | - | - | - | $230,250 | 68 | $230,250 | Sep 1 | 01 Distribution | false |
| 26 | Quinceañera | - | - | - | $218,184 | 28 | $218,184 | Sep 1 | Teodora Film | false |
| 27 | Belle toujours | - | - | - | $171,009 | 20 | $171,009 | Sep 8 | Mikado Film | false |
| 28 | DOA: Dead or Alive | - | - | - | $130,192 | 100 | $130,192 | Sep 8 | United International Pictures | false |
| 29 | Clerks II | - | - | - | $117,685 | 115 | $215,369 | Sep 29 | Mikado Film | false |
| 30 | The Road to Guantanamo | - | - | - | $116,803 | 38 | $118,887 | Sep 15 | Fandango | false |
| 31 | Dreamer | - | - | - | $111,373 | 128 | $197,933 | Sep 22 | Eagle Pictures | false |
| 32 | Time | - | - | - | $104,565 | 36 | $207,847 | Aug 25 | Mikado Film | false |
| 33 | Snakes on a Plane | - | - | - | $84,356 | 105 | $84,356 | Sep 29 | Mediafilm | false |
| 34 | The Dark Sea | - | - | - | $73,514 | 30 | $170,998 | Aug 25 | 01 Distribution | false |
| 35 | Friends with Money | - | - | - | $50,844 | 13 | $50,844 | Sep 8 | Sony Pictures Releasing | false |
| 36 | Five Fingers | - | - | - | $45,564 | 52 | $45,564 | Sep 8 | DNC Entertainment | false |
| 37 | Domino | - | - | - | $44,213 | 254 | $1,275,082 | Aug 18 | Eagle Pictures | false |
| 38 | C.R.A.Z.Y. | - | - | - | $29,315 | 80 | $166,162 | Aug 25 | Istituto Luce | false |
| 39 | What the Hell Am I Doing Here? | - | - | - | $22,585 | 34 | $39,854 | Sep 1 | Istituto Luce | false |
| 40 | Crossing the Bridge: The Sound of Istanbul | - | - | - | $18,337 | 13 | $18,337 | Sep 1 | Fandango | false |
| 41 | Volver | - | - | - | $16,635 | 309 | $8,641,208 | May 19 | Warner Bros. | false |
| 42 | 4-4-2 - Il gioco più bello del mondo | - | - | - | $16,017 | 101 | $452,097 | May 19 | Medusa Distribuzione | false |
| 43 | Lettere dal Sahara | - | - | - | $15,258 | 6 | $15,258 | Sep 1 | Istituto Luce | false |
| 44 | The Orchestra of Piazza Vittorio | - | - | - | $14,675 | 8 | $34,385 | Sep 15 | Lucky Red | false |
| 45 | Forget You Not | - | - | - | $14,052 | 20 | $14,052 | Sep 1 | Istituto Luce | false |
