| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | You, Me and Dupree | - | - | - | $8,100,765 | 412 | $15,250,701 | Aug 25 | United International Pictures | false |
| 2 | Little Man | - | - | - | $7,129,953 | 315 | $8,133,813 | Sep 1 | Sony Pictures Releasing | false |
| 3 | The Queen | - | - | - | $6,558,882 | 349 | $18,325,317 | Sep 15 | Pathé | false |
| 4 | Talladega Nights: The Ballad of Ricky Bobby | - | - | - | $4,824,131 | 404 | $6,272,154 | Sep 15 | Sony Pictures Releasing | false |
| 5 | Children of Men | - | - | - | $3,776,037 | 374 | $9,585,931 | Sep 22 | United International Pictures | false |
| 6 | The Sentinel | - | - | - | $3,771,239 | 296 | $3,888,394 | Sep 1 | 20th Century Fox International | false |
| 7 | Little Miss Sunshine | - | - | - | $3,568,853 | 173 | $6,458,370 | Sep 8 | 20th Century Fox International | false |
| 8 | The Wicker Man | - | - | - | $3,155,534 | 351 | $3,155,534 | Sep 1 | Lionsgate | false |
| 9 | Volver | - | - | - | $2,851,913 | 87 | $5,676,144 | Aug 25 | Pathé | false |
| 10 | The Black Dahlia | - | - | - | $2,699,685 | 331 | $3,176,305 | Sep 15 | Entertainment Film Distributors | false |
| 11 | Crank | - | - | - | $2,672,135 | 263 | $2,933,706 | Sep 1 | United International Pictures | false |
| 12 | Monster House | - | - | - | $2,015,035 | 430 | $12,462,338 | Aug 11 | Sony Pictures Releasing | false |
| 13 | Right at Your Door | - | - | - | $1,899,350 | 318 | $1,899,350 | Sep 8 | Lionsgate | false |
| 14 | Cars | - | - | - | $1,628,807 | 513 | $30,858,370 | Jul 28 | Buena Vista International | false |
| 15 | Snakes on a Plane | - | - | - | $1,628,643 | 359 | $7,994,471 | Aug 18 | Entertainment Film Distributors | false |
| 16 | John Tucker Must Die | - | - | - | $1,620,193 | 272 | $7,273,502 | Aug 18 | 20th Century Fox International | false |
| 17 | Lage Raho Munna Bhai | - | - | - | $1,433,212 | 38 | $1,522,624 | Sep 1 | Eros Worldwide | false |
| 18 | Open Water 2: Adrift | - | - | - | $1,343,754 | 327 | $1,343,754 | Sep 1 | Pathé | false |
| 19 | Severance | - | - | - | $1,288,964 | 302 | $3,221,022 | Aug 25 | Pathé | false |
| 20 | The Night Listener | - | - | - | $1,170,348 | 263 | $1,341,506 | Sep 15 | Icon Film Distribution Australia | false |
| 21 | Garfield: A Tail of Two Kitties | - | - | - | $962,030 | 344 | $12,212,030 | Jul 21 | 20th Century Fox International | false |
| 22 | Trust the Man | - | - | - | $858,980 | 263 | $1,116,247 | Sep 22 | Icon Film Distribution Australia | false |
| 23 | DOA: Dead or Alive | - | - | - | $850,707 | 220 | $975,792 | Sep 15 | United International Pictures | false |
| 24 | Dirty Sanchez: The Movie | - | - | - | $765,920 | 208 | $1,208,708 | Sep 22 | Pathé | false |
| 25 | Beerfest | - | - | - | $738,207 | 300 | $738,207 | Sep 8 | Warner Bros. | false |
| 26 | Pulse | - | - | - | $731,708 | 279 | $731,708 | Sep 8 | United International Pictures | false |
| 27 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $711,123 | 520 | $98,668,102 | Jul 7 | Buena Vista International | false |
| 28 | Clerks II | - | - | - | $660,846 | 245 | $919,288 | Sep 22 | United International Pictures | false |
| 29 | An Inconvenient Truth | - | - | - | $647,946 | 68 | $1,689,099 | Sep 15 | United International Pictures | false |
| 30 | A Scanner Darkly | - | - | - | $415,642 | 104 | $1,778,192 | Aug 18 | Warner Bros. | false |
| 31 | Dil Apna Punjabi | - | - | - | $403,716 | 10 | $486,065 | Sep 1 | Adlabs Films | false |
| 32 | Nacho Libre | - | - | - | $398,346 | 366 | $7,332,945 | Aug 11 | United International Pictures | false |
| 33 | Miami Vice | - | - | - | $361,462 | 412 | $13,994,361 | Aug 4 | United International Pictures | false |
| 34 | Superman Returns | - | - | - | $332,217 | 481 | $30,157,106 | Jul 14 | Warner Bros. | false |
| 35 | The Wind that Shakes the Barley | - | - | - | $329,181 | 106 | $4,778,816 | Jun 23 | Pathé | false |
| 36 | Over the Hedge | - | - | - | $295,405 | 504 | $25,901,994 | Jun 30 | United International Pictures | false |
| 37 | Kabhi Alvida Naa Kehna | - | - | - | $293,361 | 62 | $3,904,073 | Aug 11 | Yash Raj Films | false |
| 38 | The Ant Bully | - | - | - | $261,746 | 370 | $3,971,526 | Aug 4 | Warner Bros. | false |
| 39 | Driving Lessons | - | - | - | $134,193 | 36 | $285,895 | Sep 8 | Tartan | false |
| 40 | Snow Cake | - | - | - | $115,553 | 18 | $180,224 | Sep 8 | Momentum Pictures | false |
| 41 | Aap Ki Khatir | - | - | - | $109,818 | 36 | $417,460 | Aug 25 | Venus | false |
| 42 | Sillunu Oru Kaadhal | - | - | - | $70,627 | 3 | $70,627 | Sep 8 | Ayngaran International | false |
| 43 | Naksha | - | - | - | $59,185 | 7 | $59,185 | Sep 8 | Venus | false |
| 44 | Harsh Times | - | - | - | $40,650 | 217 | $1,425,718 | Aug 18 | Pathé | false |
| 45 | Angel-A | - | - | - | $37,383 | 27 | $380,937 | Jul 28 | Optimum Releasing | false |
| 46 | Pyaar Ke Side Effects | - | - | - | $30,484 | 7 | $30,484 | Sep 15 | Eros Worldwide | false |
| 47 | Renaissance | - | - | - | $26,989 | 10 | $132,165 | Jul 28 | Pathé | false |
| 48 | The Notorious Bettie Page | - | - | - | $24,881 | 16 | $293,593 | Aug 4 | Icon Film Distribution Australia | false |
| 49 | Shanghai Dreams | - | - | - | $24,592 | 3 | $37,818 | Sep 8 | Artificial Eye | false |
| 50 | Tideland | - | - | - | $21,554 | 7 | $109,578 | Aug 11 | Revolver Entertainment | false |
| 51 | Keane 2006 Re-release | - | - | - | $16,717 | 4 | $63,869 | Sep 22 | Soda Pictures | false |
| 52 | Rabbit Fever | - | - | - | $15,308 | 20 | $15,308 | Sep 22 | Maiden Voyage Pictures | false |
| 53 | Shiva | - | - | - | $14,977 | 14 | $14,977 | Sep 15 | - | false |
| 54 | Khosla Ka Ghosla! | - | - | - | $13,722 | 8 | $13,722 | Sep 22 | UTV Motion Pictures | false |
| 55 | The Front | - | - | - | $12,979 | 30 | $85,699 | Aug 25 | Buena Vista International | false |
| 56 | Look Both Ways | - | - | - | $9,280 | 10 | $59,413 | Aug 25 | Tartan | false |
| 57 | United 93 | - | - | - | $8,912 | 278 | $5,374,823 | Jun 2 | United International Pictures | false |
| 58 | Vettaiyaadu Vilaiyaadu | - | - | - | $7,888 | 2 | $7,888 | Sep 1 | Ayngaran International | false |
| 59 | Lady in the Water | - | - | - | $7,419 | 287 | $2,105,760 | Aug 11 | Warner Bros. | false |
| 60 | Three Times | - | - | - | $7,309 | 5 | $165,647 | Aug 4 | Artificial Eye | false |
| 61 | Odd Man Out 2006 Re-release | - | - | - | $5,935 | 2 | $5,935 | Sep 1 | Park Circus | false |
| 62 | Little Fish | - | - | - | $5,867 | 20 | $442,735 | Jul 21 | Tartan | false |
| 63 | Oklahoma! 2006 Re-release | - | - | - | $5,680 | 4 | $15,520 | Aug 25 | Park Circus | false |
| 64 | This Film Is Not Yet Rated | - | - | - | $4,038 | 1 | $25,133 | Sep 1 | ICA Films | false |
| 65 | Unconscious | - | - | - | $3,774 | 3 | $3,774 | Sep 15 | Maiden Voyage Pictures | false |
| 66 | The Death of Mr. Lazarescu | - | - | - | $3,766 | 4 | $86,494 | Jul 14 | Tartan | false |
| 67 | The Cave of the Yellow Dog | - | - | - | $3,581 | 17 | $258,893 | Jun 30 | Tartan | false |
| 68 | Terkel in Trouble | - | - | - | $3,396 | 17 | $3,396 | Sep 1 | Miracle Films | false |
| 69 | Heading South | - | - | - | $2,390 | 15 | $317,059 | Jul 7 | Soda Pictures | false |
| 70 | Ballets Russes | - | - | - | $1,973 | 20 | $261,752 | Apr 21 | Revolver Entertainment | false |
