| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Joker: Folie à Deux | - | - | - | $7,307,460 | 610 | $8,288,501 | Oct 3 | Warner Bros. | false |
| 2 | The Wild Robot | - | - | - | $4,919,845 | 508 | $7,164,797 | Oct 10 | Universal Pictures International (UPI) | false |
| 3 | Venom: The Last Dance | - | - | - | $4,190,845 | 428 | $7,571,093 | Oct 24 | Eagle Pictures | false |
| 4 | Parthenope | - | - | - | $2,774,564 | 585 | $7,843,568 | Oct 24 | PiperFilm | false |
| 5 | Sicilian Letters | - | - | - | $2,181,393 | 491 | $2,256,814 | Oct 10 | 01 Distribution | false |
| 6 | Vermiglio | - | - | - | $1,741,292 | 364 | $2,887,974 | Sep 19 | Lucky Red | false |
| 7 | Megalopolis | - | - | - | $1,232,833 | 350 | $1,430,466 | Oct 17 | Eagle Pictures | false |
| 8 | The Time It Takes | - | - | - | $621,025 | 333 | $949,971 | Sep 26 | 01 Distribution | false |
| 9 | Familia | - | - | - | $404,774 | 300 | $421,150 | Oct 3 | Medusa Distribuzione | false |
| 10 | Beetlejuice Beetlejuice | - | - | - | $382,194 | 539 | $5,717,183 | Sep 5 | Warner Bros. | false |
| 11 | Despicable Me 4 | - | - | - | $362,389 | 588 | $19,595,748 | Aug 21 | Universal Pictures International (UPI) | false |
| 12 | Never Let Go | - | - | - | $352,460 | 236 | $630,461 | Sep 26 | Notorious Pictures | false |
| 13 | The Teacher Who Promised the Sea | - | - | - | $305,168 | 113 | $629,354 | Sep 19 | Officine UBU | false |
| 14 | Transformers One | - | - | - | $301,706 | 330 | $917,911 | Sep 26 | Paramount Pictures International | false |
| 15 | L'amore e altre seghe mentali | - | - | - | $301,487 | 247 | $301,487 | Oct 17 | - | false |
| 16 | The Apprentice | - | - | - | $289,487 | 244 | $374,535 | Oct 17 | Istituto Luce Cinecittà | false |
| 17 | All We Imagine as Light | - | - | - | $261,914 | 79 | $261,914 | Oct 10 | Europictures | false |
| 18 | My Hero Academia: You're Next | - | - | - | $232,236 | 216 | $232,236 | Oct 10 | Eagle Pictures | false |
| 19 | Maria Montessori | - | - | - | $206,268 | 127 | $295,742 | Sep 26 | Wanted | false |
| 20 | Speak No Evil | - | - | - | $197,626 | 297 | $1,633,439 | Sep 11 | Universal Pictures International (UPI) | false |
| 21 | Ricomincio da TAAAC | - | - | - | $165,837 | 291 | $532,601 | Sep 26 | Medusa Distribuzione | false |
| 22 | An Ordinary Case | - | - | - | $149,708 | 164 | $516,726 | Sep 19 | Istituto Luce Cinecittà | false |
| 23 | The Substance | - | - | - | $133,396 | 275 | $3,054,351 | Aug 31 | I Wonder Pictures | false |
| 24 | Vittoria | - | - | - | $114,928 | 46 | $118,263 | Oct 3 | Teodora Film | false |
| 25 | Souleymane's Story | - | - | - | $100,914 | 33 | $101,794 | Oct 10 | Academy 2 | false |
| 26 | Ozi: Voice of the Forest | - | - | - | $81,864 | 311 | $435,438 | Sep 19 | Notorious Pictures | false |
| 27 | Trifole | - | - | - | $75,447 | 29 | $76,740 | Oct 17 | Officine UBU | false |
| 28 | Inside Out 2 | - | - | - | $68,313 | 578 | $50,742,101 | Jun 20 | Walt Disney Pictures | false |
| 29 | The Clean Up Crew | - | - | - | $68,041 | 119 | $68,041 | Oct 17 | Notorious Pictures | false |
| 30 | Finalement | - | - | - | $53,320 | 78 | $234,879 | Sep 19 | Europictures | false |
| 31 | Juniper | - | - | - | $42,784 | 28 | $68,769 | Oct 3 | Celsius Entertainment | false |
| 32 | Widow Clicquot | - | - | - | $36,009 | 142 | $436,239 | Sep 12 | Movies Inspired | false |
| 33 | Let Sleeping Corpses Lie | - | - | - | $34,589 | 55 | $40,468 | Oct 24 | Movies Inspired | false |
| 34 | Thelma | - | - | - | $31,421 | 197 | $233,593 | Sep 18 | Universal Pictures International (UPI) | false |
| 35 | La storia del Frank e della Nina | - | - | - | $29,339 | 62 | $31,926 | Oct 3 | Fandango | false |
| 36 | Mittran Da Challeya Truck Ni | - | - | - | $28,275 | 30 | $28,275 | Oct 17 | - | false |
| 37 | Alien: Romulus | - | - | - | $10,926 | 336 | $3,264,899 | Aug 15 | Walt Disney Pictures | false |
| 38 | Touch | - | - | - | $7,437 | 79 | $55,985 | Aug 29 | Universal Pictures International (UPI) | false |
| 39 | The Crow | - | - | - | $1,460 | 318 | $931,745 | Aug 29 | Eagle Pictures | false |
