| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | No Time to Die | - | - | - | $7,781,700 | 382 | $9,048,176 | Oct 1 | Universal Pictures International (UPI) | false |
| 2 | The Addams Family 2 | - | - | - | $3,208,052 | 337 | $5,122,557 | Oct 8 | Universal Pictures | false |
| 3 | Parallel Mothers | - | - | - | $2,463,234 | 391 | $2,991,523 | Oct 8 | Sony Pictures Releasing | false |
| 4 | Dune: Part One | - | - | - | $1,667,103 | 746 | $9,037,705 | Sep 17 | Warner Bros. | false |
| 5 | Venom: Let There Be Carnage | - | - | - | $1,646,440 | 670 | $10,400,000 | Oct 15 | Sony Pictures Releasing | false |
| 6 | Maixabel | - | - | - | $1,622,920 | 364 | $3,176,720 | Sep 24 | Walt Disney Pictures | false |
| 7 | Ron's Gone Wrong | - | - | - | $791,915 | 435 | $1,820,396 | Oct 22 | Walt Disney Studios Motion Pictures | false |
| 8 | Shang-Chi and the Legend of the Ten Rings | - | - | - | $714,928 | 341 | $6,968,395 | Sep 3 | Walt Disney Studios Motion Pictures | false |
| 9 | The Laws of the Border | - | - | - | $690,698 | 338 | $779,919 | Oct 8 | Warner Bros. | false |
| 10 | The Last Duel | - | - | - | $672,302 | 300 | $2,123,551 | Oct 29 | 20th Century Studios | false |
| 11 | Halloween Kills | - | - | - | $637,535 | 357 | $2,056,398 | Oct 22 | Universal Pictures International (UPI) | false |
| 12 | Don't Breathe 2 | - | - | - | $596,722 | 315 | $2,071,084 | Sep 24 | Sony Pictures Releasing | false |
| 13 | The French Dispatch | - | - | - | $594,876 | 205 | $1,118,511 | Oct 22 | Walt Disney Studios Motion Pictures | false |
| 14 | The Good Boss | - | - | - | $442,555 | 309 | $4,331,817 | Oct 15 | Miramax | false |
| 15 | ¡A todo tren! Destino Asturias | - | - | - | $240,536 | 400 | $9,544,171 | Jul 9 | Warner Bros. | false |
| 16 | The Courier | - | - | - | $233,724 | 211 | $586,970 | Oct 29 | Diamond Films | false |
| 17 | Titane | - | - | - | $224,606 | 111 | $230,390 | Oct 8 | Caramel Films | false |
| 18 | Terremoto | - | - | - | $212,496 | 248 | $534,013 | Oct 1 | Begin Again Films | false |
| 19 | Medjugorje, la película | - | - | - | $169,540 | 56 | $347,693 | Oct 1 | European Dreams Factory | false |
| 20 | Family Swap | - | - | - | $121,960 | 194 | $818,538 | Sep 10 | DeAPlaneta | false |
| 21 | Cry Macho | - | - | - | $120,440 | 277 | $836,029 | Sep 24 | Warner Bros. | false |
| 22 | The Boss Baby 2: Family Business | - | - | - | $117,625 | 403 | $5,239,010 | Aug 6 | Universal Pictures International (UPI) | false |
| 23 | Free Guy | - | - | - | $93,655 | 325 | $3,607,833 | Aug 18 | Walt Disney Pictures | false |
| 24 | Mediterraneo: The Law of the Sea | - | - | - | $72,137 | 248 | $493,808 | Oct 1 | DeAPlaneta | false |
| 25 | Dogtanian and the Three Muskehounds | - | - | - | $45,463 | 609 | $1,291,150 | Sep 3 | A Contracorriente Films | false |
| 26 | España, la primera globalización | - | - | - | $42,845 | 61 | $298,603 | Oct 15 | - | false |
| 27 | Jungle Cruise | - | - | - | $36,897 | 398 | $4,078,906 | Jul 30 | Walt Disney Studios Motion Pictures | false |
| 28 | Supernova | - | - | - | $32,095 | 83 | $32,382 | Oct 22 | Wanda Visión S.A. | false |
| 29 | The Rose Maker | - | - | - | $29,567 | 56 | $29,567 | Oct 22 | BTeam Pictures | false |
| 30 | Ella Bella Bingo | - | - | - | $29,139 | 159 | $136,316 | Oct 1 | Elamedia Estudios | false |
| 31 | Claret | - | - | - | $25,158 | 39 | $76,564 | Sep 24 | - | false |
| 32 | Benedetta | - | - | - | $25,091 | 133 | $155,359 | Oct 1 | Avalon | false |
| 33 | Garcia & Garcia | - | - | - | $17,619 | 304 | $1,133,254 | Aug 27 | A Contracorriente Films | false |
| 34 | Malignant | - | - | - | $17,615 | 313 | $2,126,260 | Sep 3 | Warner Bros. | false |
| 35 | Chavalas | - | - | - | $12,945 | 73 | $265,314 | Sep 3 | Filmax | false |
| 36 | Nomadland | - | - | - | $9,663 | 91 | $2,753,594 | Mar 26 | Walt Disney Pictures | false |
| 37 | Respect | - | - | - | $7,868 | 140 | $212,929 | Sep 24 | Universal Pictures | false |
| 38 | Sevillanas de Brooklyn | - | - | - | $5,883 | 100 | $126,635 | Sep 17 | Filmax | false |
| 39 | Who's Stopping Us | - | - | - | $4,010 | 235 | $19,597 | Oct 29 | Atalanta Filmes | false |
| 40 | Negro Purpura | - | - | - | $2,966 | 8 | $10,370 | Sep 24 | Begin Again Films | false |
| 41 | Nora | - | - | - | $2,444 | 26 | $65,505 | Sep 3 | Sherlock Films | false |
| 42 | Black Widow | - | - | - | $1,870 | 349 | $7,329,424 | Jul 9 | Walt Disney Pictures | false |
| 43 | Wojtyla. La investigación | - | - | - | $1,843 | 1 | $4,369 | - | European Dreams Factory | false |
| 44 | Vivo | - | - | - | $1,578 | 8 | $253,735 | Jun 17 | Bosco Films | false |
| 45 | Zutik | - | - | - | $1,446 | 14 | $6,296 | Oct 22 | Filmax | false |
| 46 | Callejeras | - | - | - | $1,378 | 1 | $2,426 | Oct 22 | - | false |
| 47 | Nur eta herensugearen tenplua 2021 Re-release | - | - | - | $688 | 7 | $6,427 | - | Barton Films | false |
| 48 | Undercover Wedding Crashers | - | - | - | $684 | 353 | $3,871,185 | Jun 25 | Walt Disney Pictures | false |
| 49 | Con quién viajas | - | - | - | $463 | 221 | $145,094 | Sep 10 | A Contracorriente Films | false |
| 50 | Strange Voyage 2021 Re-release | - | - | - | $423 | 3 | $746 | Oct 22 | A Contracorriente Films | false |
| 51 | Descarrilados | - | - | - | $338 | 350 | $1,147,367 | Aug 20 | Sony Pictures Releasing | false |
| 52 | The Unemployment Club | - | - | - | $277 | 66 | $61,315 | Sep 17 | Vértice 360 | false |
| 53 | The Day of the Beast 2021 Re-release | - | - | - | $266 | 4 | $9,984 | Oct 15 | Con Un Pack Distribución | false |
| 54 | The Return: Life After ISIS | - | - | - | $233 | 1 | $2,933 | May 28 | - | false |
| 55 | Mighty Flash | - | - | - | $131 | 20 | $19,445 | Jun 18 | - | false |
| 56 | The Consequences | - | - | - | $78 | 25 | $28,334 | Sep 17 | Syldavia Cinema | false |
| 57 | Yesterday's Two Nights | - | - | - | $65 | 1 | $12,889 | Mar 12 | Splendor Films | false |
| 58 | Aztarnak - Huellas | - | - | - | $57 | 2 | $3,161 | Oct 15 | Barton Films | false |
| 59 | Olvido y León | - | - | - | $39 | 1 | $5,280 | Mar 26 | - | false |
| 60 | Clown's planet | - | - | - | $30 | 1 | $132 | Oct 1 | Con Un Pack Distribución | false |
| 61 | Billy | - | - | - | $21 | 2 | $4,578 | Sep 17 | Begin Again Films | false |
