| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $1,621,737 | 56 | $1,785,409 | Oct 1 | Warner Bros. | false |
| 2 | The Zero Hour | - | - | - | $1,219,816 | 45 | $3,947,360 | Oct 8 | - | false |
| 3 | The Town | - | - | - | $592,976 | 54 | $701,482 | Oct 15 | Warner Bros. | false |
| 4 | Predators | - | - | - | $591,992 | 46 | $597,533 | Oct 1 | 20th Century Fox International | false |
| 5 | The Sorcerer's Apprentice | - | - | - | $529,271 | 66 | $2,603,094 | Sep 3 | Walt Disney Pictures | false |
| 6 | Resident Evil: Afterlife | - | - | - | $414,948 | 73 | $2,447,898 | Sep 10 | Sony Pictures Releasing | false |
| 7 | The Other Guys | - | - | - | $381,953 | 31 | $789,539 | Sep 17 | Sony Pictures Releasing | false |
| 8 | Piranha 3D | - | - | - | $357,454 | 33 | $379,696 | Oct 15 | - | false |
| 9 | Furry Vengeance | - | - | - | $307,626 | 32 | $899,826 | Sep 3 | - | false |
| 10 | The Box | - | - | - | $304,670 | 33 | $311,040 | Oct 1 | - | false |
| 11 | Saw 3D | - | - | - | $250,576 | 42 | $1,151,381 | Oct 29 | Walt Disney Pictures | false |
| 12 | Tinker Bell and the Great Fairy Rescue | - | - | - | $173,103 | 15 | $345,335 | Sep 24 | Walt Disney Pictures | false |
| 13 | The Last Airbender | - | - | - | $172,048 | 63 | $2,262,106 | Aug 27 | United International Pictures | false |
| 14 | Las Caras del Diablo | - | - | - | $165,768 | 15 | $315,079 | Sep 17 | - | false |
| 15 | Vampires Suck | - | - | - | $130,388 | 43 | $406,169 | Oct 29 | 20th Century Fox International | false |
| 16 | Eat Pray Love | - | - | - | $126,659 | 40 | $570,588 | Oct 29 | Sony Pictures Releasing | false |
| 17 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $88,869 | 88 | $1,686,812 | Aug 27 | Warner Bros. | false |
| 18 | Brother | - | - | - | $67,708 | 25 | $1,556,003 | Jul 2 | - | false |
| 19 | Chéri | - | - | - | $62,494 | 5 | $63,958 | Oct 1 | - | false |
| 20 | Grown Ups | - | - | - | $61,777 | 70 | $2,541,731 | Jul 30 | Sony Pictures Releasing | false |
| 21 | Despicable Me | - | - | - | $55,423 | 83 | $2,321,604 | Aug 13 | United International Pictures | false |
| 22 | Grace Is Gone | - | - | - | $55,092 | 5 | $59,384 | Oct 1 | - | false |
| 23 | Going the Distance | - | - | - | $54,589 | 40 | $451,433 | Sep 3 | Warner Bros. | false |
| 24 | Habana Eva | - | - | - | $37,493 | 23 | $707,988 | Aug 6 | - | false |
| 25 | My One and Only | - | - | - | $33,445 | 7 | $39,487 | Oct 22 | - | false |
| 26 | Inception | - | - | - | $32,533 | 67 | $1,570,718 | Aug 6 | Warner Bros. | false |
| 27 | Taita Boves | - | - | - | $21,773 | 12 | $150,247 | Aug 27 | - | false |
| 28 | El Estudiante 2010 Re-release | - | - | - | $18,065 | 3 | $40,099 | Sep 10 | - | false |
| 29 | The Last Song | - | - | - | $16,201 | 12 | $127,211 | Aug 20 | Walt Disney Pictures | false |
| 30 | Extremos | - | - | - | $9,176 | 10 | $45,567 | Oct 29 | - | false |
| 31 | Inland Empire 2010 Re-release | - | - | - | $6,049 | 2 | $7,204 | Oct 8 | - | false |
| 32 | The Karate Kid | - | - | - | $3,219 | 78 | $2,639,233 | Aug 6 | Sony Pictures Releasing | false |
| 33 | The Appeared | - | - | - | $1,799 | 1 | $1,799 | Oct 15 | - | false |
| 34 | Parque vía 2010 Re-release | - | - | - | $1,368 | 3 | $1,368 | Oct 22 | - | false |
| 35 | Shrek Forever After | - | - | - | $938 | 87 | $5,984,037 | Jul 9 | United International Pictures | false |
| 36 | Crazy Heart | - | - | - | $736 | 3 | $25,971 | Sep 3 | 20th Century Fox International | false |
