| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Eat Pray Love | - | - | - | $185,705 | 6 | $230,175 | Oct 1 | Sony Pictures Releasing | false |
| 2 | The Last Airbender | - | - | - | $90,243 | 8 | $93,747 | Oct 1 | Paramount Pictures International | false |
| 3 | Grown Ups | - | - | - | $87,456 | 8 | $198,914 | Sep 17 | Sony Pictures Releasing | false |
| 4 | Life as We Know It | - | - | - | $59,382 | 6 | $83,988 | Oct 15 | Warner Bros. | false |
| 5 | The Social Network | - | - | - | $51,602 | 5 | $84,986 | Oct 15 | Sony Pictures Releasing | false |
| 6 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $43,329 | 8 | $46,565 | Oct 8 | Warner Bros. | false |
| 7 | Wall Street: Money Never Sleeps | - | - | - | $41,502 | 7 | $73,336 | Sep 24 | 20th Century Fox International | false |
| 8 | Igualita a mí | - | - | - | $41,199 | 9 | $151,043 | Sep 10 | Walt Disney Pictures | false |
| 9 | Solitary Man | - | - | - | $37,660 | 4 | $39,294 | Oct 8 | - | false |
| 10 | Saw 3D | - | - | - | $26,248 | 6 | $127,998 | Oct 29 | - | false |
| 11 | Nanny McPhee Returns | - | - | - | $23,345 | 5 | $45,319 | Sep 24 | Universal Pictures International (UPI) | false |
| 12 | Predators | - | - | - | $22,840 | 5 | $22,840 | Oct 8 | 20th Century Fox International | false |
| 13 | The Expendables | - | - | - | $20,786 | 4 | $20,786 | Oct 15 | - | false |
| 14 | Hachi: A Dog's Tale | - | - | - | $20,130 | 5 | $22,019 | Oct 15 | - | false |
| 15 | Resident Evil: Afterlife | - | - | - | $19,482 | 8 | $161,693 | Sep 10 | Sony Pictures Releasing | false |
| 16 | Norberto's Deadline | - | - | - | $19,346 | 3 | $23,494 | Oct 1 | - | false |
| 17 | Gaturro | - | - | - | $19,085 | 4 | $41,009 | Oct 22 | - | false |
| 18 | The Town | - | - | - | $18,814 | 7 | $43,104 | Oct 29 | Warner Bros. | false |
| 19 | Inception | - | - | - | $12,698 | 9 | $282,465 | Jul 30 | Warner Bros. | false |
| 20 | Tinker Bell and the Great Fairy Rescue | - | - | - | $10,414 | 5 | $51,703 | Sep 10 | Walt Disney Pictures | false |
| 21 | Nora's Will | - | - | - | $9,958 | 1 | $12,136 | Sep 24 | - | false |
| 22 | Vincere | - | - | - | $8,226 | 2 | $14,457 | Sep 24 | - | false |
| 23 | Going the Distance | - | - | - | $6,329 | 5 | $32,988 | Sep 17 | Warner Bros. | false |
| 24 | Seraphine | - | - | - | $4,863 | 1 | $20,801 | Sep 3 | - | false |
| 25 | The Man Next Door | - | - | - | $4,839 | 3 | $30,098 | Oct 29 | - | false |
| 26 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $4,818 | 9 | $189,716 | Aug 20 | Warner Bros. | false |
| 27 | Little Girl | - | - | - | $3,832 | 1 | $4,915 | Sep 24 | - | false |
| 28 | Step Up 3D | - | - | - | $3,615 | 5 | $3,615 | Oct 29 | Walt Disney Pictures | false |
| 29 | Pope Joan | - | - | - | $3,047 | 2 | $7,606 | Oct 29 | - | false |
| 30 | The Sorcerer's Apprentice | - | - | - | $2,798 | 5 | $72,117 | Aug 27 | Walt Disney Pictures | false |
| 31 | A Single Man | - | - | - | $1,657 | 3 | $9,975 | Sep 17 | - | false |
| 32 | Furry Vengeance | - | - | - | $1,013 | 2 | $12,530 | Sep 17 | - | false |
| 33 | Despicable Me | - | - | - | $881 | 8 | $159,938 | Jul 30 | Universal Pictures International (UPI) | false |
| 34 | Pax Americana and the Weaponization of Space | - | - | - | $857 | 1 | $857 | Oct 8 | - | false |
| 35 | Five Minutes of Heaven | - | - | - | $670 | 1 | $5,224 | Sep 17 | - | false |
| 36 | Micmacs | - | - | - | $636 | 1 | $4,389 | Oct 29 | Sony Pictures Releasing | false |
| 37 | Rembrandt's J'Accuse | - | - | - | $629 | 1 | $10,104 | Sep 3 | - | false |
| 38 | The Road | - | - | - | $567 | 3 | $16,198 | Sep 10 | - | false |
| 39 | A Useful Life | - | - | - | $560 | 1 | $9,536 | Aug 13 | - | false |
| 40 | Salt | - | - | - | $516 | 5 | $94,492 | Aug 13 | Sony Pictures Releasing | false |
| 41 | In Your Name | - | - | - | $504 | 1 | $504 | Oct 8 | - | false |
| 42 | Birds of Paradise | - | - | - | $316 | 3 | $3,664 | Sep 17 | - | false |
| 43 | The Ghost Writer | - | - | - | $218 | 5 | $69,635 | Aug 6 | - | false |
| 44 | Letters to Juliet | - | - | - | $196 | 4 | $65,534 | Aug 20 | - | false |
