| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Despicable Me | - | - | - | $278,673 | 18 | $362,636 | Oct 14 | United International Pictures | false |
| 2 | Eat Pray Love | - | - | - | $236,941 | 8 | $386,410 | Sep 23 | Sony Pictures Releasing | false |
| 3 | Step Up 3D | - | - | - | $134,569 | 6 | $227,845 | Sep 23 | - | false |
| 4 | Saw 3D | - | - | - | $122,556 | 11 | $313,423 | Oct 28 | - | false |
| 5 | Dinner for Schmucks | - | - | - | $86,934 | 8 | $173,663 | Sep 16 | United International Pictures | false |
| 6 | The Sorcerer's Apprentice | - | - | - | $73,403 | 10 | $147,564 | Sep 16 | Walt Disney Pictures | false |
| 7 | The Other Guys | - | - | - | $72,189 | 7 | $110,987 | Oct 21 | Sony Pictures Releasing | false |
| 8 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $43,944 | 11 | $46,889 | Sep 30 | Warner Bros. | false |
| 9 | The Switch | - | - | - | $35,882 | 3 | $51,404 | Oct 7 | - | false |
| 10 | Going the Distance | - | - | - | $31,628 | 7 | $88,262 | Sep 9 | Warner Bros. | false |
| 11 | The Social Network | - | - | - | $27,473 | 7 | $153,204 | Oct 28 | Sony Pictures Releasing | false |
| 12 | You Again | - | - | - | $23,956 | 6 | $91,973 | Oct 28 | Walt Disney Pictures | false |
| 13 | Toy Story 3 | - | - | - | $23,707 | 13 | $234,447 | Aug 12 | Walt Disney Pictures | false |
| 14 | Devil | - | - | - | $18,743 | 7 | $70,951 | Oct 28 | United International Pictures | false |
| 15 | Scott Pilgrim vs. the World | - | - | - | $18,586 | 6 | $20,495 | Sep 30 | United International Pictures | false |
| 16 | Chatroom | - | - | - | $17,930 | 6 | $21,019 | Oct 21 | - | false |
| 17 | Resident Evil: Afterlife | - | - | - | $17,495 | 17 | $90,699 | Sep 10 | Sony Pictures Releasing | false |
| 18 | The Karate Kid | - | - | - | $12,427 | 12 | $120,832 | Sep 2 | Sony Pictures Releasing | false |
| 19 | The Crazies | - | - | - | $11,348 | 2 | $17,928 | Sep 23 | - | false |
| 20 | Salt | - | - | - | $8,214 | 10 | $181,929 | Aug 19 | Sony Pictures Releasing | false |
| 21 | Machete | - | - | - | $7,831 | 4 | $49,648 | Sep 2 | - | false |
| 22 | Charlie St. Cloud | - | - | - | $1,513 | 8 | $26,102 | Sep 9 | United International Pictures | false |
