| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $1,228,156 | 63 | $1,330,099 | Oct 7 | Warner Bros. | false |
| 2 | Nanny McPhee Returns | - | - | - | $553,229 | 34 | $591,121 | Sep 30 | Universal Pictures International (UPI) | false |
| 3 | The Last Exorcism | - | - | - | $422,468 | 32 | $497,696 | Oct 14 | - | false |
| 4 | Salt | - | - | - | $376,595 | 42 | $377,221 | Sep 30 | Sony Pictures Releasing | false |
| 5 | Resident Evil: Afterlife | - | - | - | $337,130 | 67 | $1,262,371 | Sep 16 | Sony Pictures Releasing | false |
| 6 | Furry Vengeance | - | - | - | $311,940 | 27 | $470,819 | Oct 14 | Venus | false |
| 7 | Killers | - | - | - | $236,283 | 30 | $254,090 | Oct 7 | - | false |
| 8 | Walled In | - | - | - | $232,673 | 25 | $232,673 | Sep 30 | - | false |
| 9 | Wall Street: Money Never Sleeps | - | - | - | $212,790 | 25 | $355,638 | Sep 23 | 20th Century Fox International | false |
| 10 | Piranha 3D | - | - | - | $204,288 | 23 | $494,194 | Oct 28 | - | false |
| 11 | Eat Pray Love | - | - | - | $199,375 | 17 | $346,983 | Oct 21 | Sony Pictures Releasing | false |
| 12 | The Town | - | - | - | $152,149 | 25 | $243,273 | Oct 21 | Warner Bros. | false |
| 13 | Going the Distance | - | - | - | $116,440 | 26 | $327,280 | Sep 16 | Warner Bros. | false |
| 14 | Life as We Know It | - | - | - | $109,721 | 26 | $540,281 | Oct 28 | Warner Bros. | false |
| 15 | Mongol: The Rise of Genghis Khan | - | - | - | $102,942 | 12 | $120,914 | Oct 14 | - | false |
| 16 | The Other Guys | - | - | - | $92,043 | 30 | $207,262 | Sep 23 | Sony Pictures Releasing | false |
| 17 | Tinker Bell and the Great Fairy Rescue | - | - | - | $91,241 | 25 | $309,056 | Sep 16 | Walt Disney Pictures | false |
| 18 | Possession | - | - | - | $79,041 | 16 | $87,871 | Sep 30 | - | false |
| 19 | Law Abiding Citizen | - | - | - | $76,663 | 12 | $88,346 | Oct 14 | - | false |
| 20 | Takers 2010 Re-release | - | - | - | $72,083 | 25 | $79,560 | Oct 14 | Sony Pictures Releasing | false |
| 21 | Paranormal Activity 2 | - | - | - | $67,848 | 40 | $967,470 | Nov 4 | Paramount Pictures International | false |
| 22 | Vampires Suck | - | - | - | $67,128 | 25 | $316,645 | Sep 2 | 20th Century Fox International | false |
| 23 | The Secret in Their Eyes | - | - | - | $66,805 | 14 | $116,376 | Sep 23 | - | false |
| 24 | Solomon Kane | - | - | - | $57,829 | 25 | $172,832 | Oct 28 | Venus | false |
| 25 | The Last Airbender | - | - | - | $51,801 | 75 | $2,120,847 | Aug 26 | Paramount Pictures International | false |
| 26 | Battle for Terra | - | - | - | $41,886 | 13 | $41,886 | Oct 21 | - | false |
| 27 | The Road | - | - | - | $36,752 | 12 | $40,356 | Oct 21 | - | false |
| 28 | Oceans | - | - | - | $35,045 | 13 | $81,657 | Sep 23 | - | false |
| 29 | The Expendables | - | - | - | $34,090 | 32 | $454,296 | Sep 9 | - | false |
| 30 | Art of the Devil 3 2010 Re-release | - | - | - | $33,799 | 10 | $68,491 | Sep 23 | - | false |
| 31 | The Other Man | - | - | - | $24,619 | 12 | $61,007 | Oct 28 | - | false |
| 32 | Grown Ups | - | - | - | $19,952 | 40 | $646,840 | Aug 19 | Sony Pictures Releasing | false |
| 33 | A Single Man | - | - | - | $15,914 | 6 | $18,259 | Oct 21 | - | false |
| 34 | October | - | - | - | $14,126 | 10 | $52,270 | Oct 7 | United International Pictures | false |
| 35 | La Vigilia | - | - | - | $12,673 | 13 | $29,562 | Oct 28 | Andes Films | false |
| 36 | The Spy Next Door 2010 Re-release | - | - | - | $12,320 | 27 | $422,376 | Jul 1 | - | false |
| 37 | Labor Pains | - | - | - | $11,861 | 17 | $129,778 | Sep 9 | - | false |
| 38 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $10,917 | 66 | $1,304,761 | Aug 12 | Warner Bros. | false |
| 39 | The Haunting of Molly Hartley | - | - | - | $8,417 | 20 | $152,014 | Aug 19 | - | false |
| 40 | Pandorum | - | - | - | $7,560 | 8 | $31,258 | Oct 28 | - | false |
| 41 | The Haunting | - | - | - | $7,213 | 25 | $270,795 | Sep 2 | - | false |
| 42 | Friend Zone 2010 Re-release | - | - | - | $5,632 | 10 | $44,061 | Sep 9 | - | false |
| 43 | Killshot | - | - | - | $4,845 | 12 | $69,634 | Oct 7 | - | false |
| 44 | Predators | - | - | - | $3,662 | 37 | $434,779 | Aug 19 | 20th Century Fox International | false |
| 45 | Pope Joan | - | - | - | $2,961 | 14 | $50,008 | Aug 19 | - | false |
| 46 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $2,612 | 16 | $122,730 | Sep 2 | - | false |
| 47 | From Paris with Love | - | - | - | $2,455 | 22 | $127,445 | Aug 26 | - | false |
| 48 | The Young Victoria | - | - | - | $2,393 | 8 | $59,905 | Sep 30 | - | false |
| 49 | Messengers 2: The Scarecrow | - | - | - | $2,020 | 18 | $91,881 | Aug 12 | - | false |
| 50 | Lila, Lila | - | - | - | $1,615 | 15 | $84,928 | Aug 26 | - | false |
| 51 | Letters to Juliet | - | - | - | $823 | 25 | $165,112 | Aug 19 | Venus | false |
| 52 | The Back-up Plan | - | - | - | $459 | 29 | $369,996 | Jun 24 | Sony Pictures Releasing | false |
| 53 | Despicable Me | - | - | - | $256 | 62 | $2,092,292 | Jul 28 | Universal Pictures International (UPI) | false |
| 54 | Illary | - | - | - | $246 | 10 | $10,631 | Jun 17 | - | false |
| 55 | The Last Song | - | - | - | $217 | 13 | $117,319 | Jun 3 | Walt Disney Pictures | false |
| 56 | Love Happens | - | - | - | $175 | 16 | $86,093 | May 27 | - | false |
