Italian Box Office For October 2010
| Rank | Release | Gross | Max Th | Opening | % of Total | Open Th | Open | Close | Distributor |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Welcome to the South | $43,015,634 | 568 | $5,231,564 | 12.2% | 532 | Oct 1 | - | Medusa Distribuzione |
| 2 | Men Vs Women | $18,452,860 | 575 | $4,222,767 | 22.9% | 572 | Oct 27 | - | 01 Distribution |
| 3 | Despicable Me | $17,064,781 | 544 | $4,902,039 | 28.7% | 544 | Oct 15 | - | United International Pictures |
| 4 | Step Up 3D | $9,282,511 | 339 | $3,312,589 | 35.7% | 339 | Oct 8 | - | Eagle Pictures |
| 5 | Wall Street: Money Never Sleeps | $4,137,171 | 324 | $1,544,534 | 37.3% | 324 | Oct 22 | - | 20th Century Fox International |
| 6 | Winx Club 3D: Magical Adventure | $3,872,632 | 382 | $935,111 | 24.1% | 360 | Oct 29 | - | Medusa Distribuzione |
| 7 | Paranormal Activity 2 | $3,856,430 | 250 | $1,538,955 | 39.9% | 250 | Oct 22 | - | United International Pictures |
| 8 | The Town | $3,203,649 | 254 | $1,056,842 | 33% | 254 | Oct 8 | - | Warner Bros. |
| 9 | Salt | $3,187,250 | 297 | $1,048,329 | 32.9% | 297 | Oct 29 | - | Sony Pictures Releasing |
| 10 | Knight and Day Original Release | $2,816,693 | 374 | $1,235,593 | 43.9% | 374 | Oct 8 | - | 20th Century Fox International |
| 11 | The Extraordinary Adventures of Adèle Blanc-Sec | $2,191,940 | 260 | $1,102,111 | 50.3% | 260 | Oct 15 | - | Medusa Distribuzione |
| 12 | Legend of the Guardians: The Owls of Ga'Hoole | $2,177,011 | 298 | $559,946 | 25.7% | 298 | Oct 29 | - | Warner Bros. |
| 13 | Buried | $2,127,617 | 166 | $1,041,443 | 48.9% | 166 | Oct 15 | - | - |
| 14 | Unlikely Revolutionaries | $2,104,909 | 265 | $787,361 | 37.4% | 265 | Oct 22 | - | Warner Bros. |
| 15 | Of Gods and Men | $1,891,721 | 65 | $188,682 | 10% | 53 | Oct 22 | - | Lucky Red |
| 16 | A Second Childhood | $1,367,507 | 189 | $509,731 | 37.3% | - | Oct 8 | - | 01 Distribution |
| 17 | Fair Game | $1,248,756 | 199 | $603,172 | 48.3% | 199 | Oct 22 | - | Eagle Pictures |
| 18 | Grown Ups | $1,034,575 | 202 | $499,698 | 48.3% | 202 | Oct 1 | - | Sony Pictures Releasing |
| 19 | The City of Your Final Destination | $916,654 | 58 | $175,821 | 19.2% | 50 | Oct 8 | - | Teodora Film |
| 20 | Gorbaciof | $879,825 | 133 | $368,747 | 41.9% | 133 | Oct 15 | - | Lucky Red |
| 21 | The Black Sheep | $820,140 | 66 | $154,898 | 18.9% | 65 | Oct 1 | - | BIM Distribuzione |
| 22 | Tutti giù per terra | $771,254 | 1 | $1,291 | 0.2% | 1 | Oct 24 | - | - |
| 23 | Passione | $452,105 | 39 | $73,569 | 16.3% | 39 | Oct 22 | - | 01 Distribution |
| 24 | The Illusionist | $317,410 | 19 | $46,314 | 14.6% | 19 | Oct 29 | - | Sacher Distribuzione |
| 25 | Mammuth | $302,913 | 28 | $73,515 | 24.3% | 22 | Oct 29 | - | Fandango |
| 26 | Horse | $292,786 | 86 | $138,441 | 47.3% | 86 | Oct 1 | - | Fandango |
| 27 | Animal Kingdom | $190,504 | 36 | $61,441 | 32.3% | 36 | Oct 29 | - | Mikado Film |
| 28 | Seraphine | $169,425 | 12 | $14,741 | 8.7% | 12 | Oct 22 | - | One Movie |
| 29 | Uncle Boonmee Who Can Recall His Past Lives | $161,192 | 17 | $64,926 | 40.3% | - | Oct 15 | - | BIM Distribuzione |
| 30 | Pugni chiusi | $55,539 | 1 | - | - | - | Oct 1 | - | - |
| 31 | Post Mortem | $48,190 | 2 | - | - | - | Oct 29 | - | Archibald |
| 32 | 40% - Le mani libere del destino | $11,626 | 1 | - | - | - | Oct 22 | - | - |
| 33 | L'estate d'inverno | $4,853 | 4 | $4,853 | 100% | 4 | Oct 15 | - | - |
