| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Welcome to the South | - | - | - | $32,825,807 | 568 | $43,015,634 | Oct 1 | Medusa Distribuzione | false |
| 2 | Despicable Me | - | - | - | $12,458,016 | 544 | $17,064,781 | Oct 15 | United International Pictures | false |
| 3 | Step Up 3D | - | - | - | $9,120,177 | 339 | $9,282,511 | Oct 8 | Eagle Pictures | false |
| 4 | Inception | - | - | - | $8,877,092 | 585 | $15,459,083 | Sep 24 | Warner Bros. | false |
| 5 | Men Vs Women | - | - | - | $4,222,767 | 575 | $18,452,860 | Oct 27 | 01 Distribution | false |
| 6 | The Last Airbender | - | - | - | $3,678,707 | 438 | $7,821,944 | Sep 24 | United International Pictures | false |
| 7 | The Town | - | - | - | $3,227,803 | 254 | $3,203,649 | Oct 8 | Warner Bros. | false |
| 8 | Wall Street: Money Never Sleeps | - | - | - | $2,873,226 | 324 | $4,137,171 | Oct 22 | 20th Century Fox International | false |
| 9 | Paranormal Activity 2 | - | - | - | $2,862,761 | 250 | $3,856,430 | Oct 22 | United International Pictures | false |
| 10 | Knight and Day 2010 Re-release | - | - | - | $2,816,693 | 374 | $2,816,693 | Oct 8 | 20th Century Fox International | false |
| 11 | The Extraordinary Adventures of Adèle Blanc-Sec | - | - | - | $2,122,659 | 260 | $2,191,940 | Oct 15 | Medusa Distribuzione | false |
| 12 | Buried | - | - | - | $2,010,512 | 166 | $2,127,617 | Oct 15 | - | false |
| 13 | La passione di Laura | - | - | - | $1,665,052 | 63 | $3,132,470 | Sep 24 | 01 Distribution | false |
| 14 | Unlikely Revolutionaries | - | - | - | $1,439,895 | 265 | $2,104,909 | Oct 22 | Warner Bros. | false |
| 15 | Toy Story 3 | - | - | - | $1,427,600 | 678 | $18,855,881 | Jul 7 | Walt Disney Pictures | false |
| 16 | A Second Childhood | - | - | - | $1,293,856 | 189 | $1,367,507 | Oct 8 | 01 Distribution | false |
| 17 | Fair Game | - | - | - | $1,103,907 | 199 | $1,248,756 | Oct 22 | Eagle Pictures | false |
| 18 | Salt | - | - | - | $1,048,329 | 297 | $3,187,250 | Oct 29 | Sony Pictures Releasing | false |
| 19 | Grown Ups | - | - | - | $1,034,575 | 202 | $1,034,575 | Oct 1 | Sony Pictures Releasing | false |
| 20 | Winx Club 3D: Magical Adventure | - | - | - | $935,111 | 382 | $3,872,632 | Oct 29 | Medusa Distribuzione | false |
| 21 | Vampires Suck | - | - | - | $888,001 | 296 | $6,000,711 | Sep 17 | 20th Century Fox International | false |
| 22 | Eat Pray Love | - | - | - | $807,495 | 320 | $5,000,639 | Sep 17 | Sony Pictures Releasing | false |
| 23 | Sharm el Sheikh - Un'estate indimenticabile | - | - | - | $769,270 | 291 | $4,427,419 | Sep 17 | Medusa Distribuzione | false |
| 24 | Gorbaciof | - | - | - | $731,596 | 133 | $879,825 | Oct 15 | Lucky Red | false |
| 25 | The City of Your Final Destination | - | - | - | $721,378 | 58 | $916,654 | Oct 8 | Teodora Film | false |
| 26 | The Sorcerer's Apprentice | - | - | - | $717,325 | 443 | $9,571,490 | Aug 18 | Walt Disney Pictures | false |
| 27 | The Black Sheep | - | - | - | $715,607 | 66 | $820,140 | Oct 1 | BIM Distribuzione | false |
| 28 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $559,946 | 298 | $2,177,011 | Oct 29 | Warner Bros. | false |
| 29 | Of Gods and Men | - | - | - | $545,914 | 65 | $1,891,721 | Oct 22 | Lucky Red | false |
| 30 | Shrek Forever After | - | - | - | $452,906 | 793 | $23,451,561 | Aug 25 | United International Pictures | false |
| 31 | Basilicata Coast to Coast | - | - | - | $350,836 | 196 | $4,588,816 | Apr 9 | Eagle Pictures | false |
| 32 | The Solitude of Prime Numbers | - | - | - | $338,719 | 371 | $4,928,162 | Sep 10 | Medusa Distribuzione | false |
| 33 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $317,194 | 261 | $1,833,580 | Sep 17 | Warner Bros. | false |
| 34 | The Expendables | - | - | - | $312,511 | 326 | $4,104,395 | Sep 1 | 01 Distribution | false |
| 35 | Horse | - | - | - | $292,786 | 86 | $292,786 | Oct 1 | Fandango | false |
| 36 | Somewhere | - | - | - | $193,221 | 240 | $2,783,084 | Sep 3 | Medusa Distribuzione | false |
| 37 | Passione | - | - | - | $181,677 | 39 | $452,105 | Oct 22 | 01 Distribution | false |
| 38 | The Secret in Their Eyes | - | - | - | $144,754 | 73 | $1,566,701 | Jun 4 | Lucky Red | false |
| 39 | Uncle Boonmee Who Can Recall His Past Lives | - | - | - | $118,743 | 17 | $161,192 | Oct 15 | BIM Distribuzione | false |
| 40 | Law Abiding Citizen | - | - | - | $79,842 | 254 | $6,595,412 | Aug 25 | - | false |
| 41 | Mammuth | - | - | - | $73,515 | 28 | $302,913 | Oct 29 | Fandango | false |
| 42 | Animal Kingdom | - | - | - | $61,441 | 36 | $190,504 | Oct 29 | Mikado Film | false |
| 43 | London River 2010 Re-release | - | - | - | $52,452 | 39 | $324,215 | Aug 27 | BIM Distribuzione | false |
| 44 | The Illusionist | - | - | - | $46,314 | 19 | $317,410 | Oct 29 | Sacher Distribuzione | false |
| 45 | Step Up 2: The Streets | - | - | - | $40,504 | 333 | $5,313,261 | Apr 18 | Moviemax | false |
| 46 | Seraphine | - | - | - | $39,946 | 12 | $169,425 | Oct 22 | One Movie | false |
| 47 | 20 Cigarettes | - | - | - | $39,252 | 21 | $332,955 | Sep 10 | Istituto Luce | false |
| 48 | Howl | - | - | - | $34,953 | 32 | $305,337 | Aug 27 | Fandango | false |
| 49 | Niente paura | - | - | - | $23,615 | 1 | $750,404 | Sep 17 | - | false |
| 50 | My Son, My Son, What Have Ye Done | - | - | - | $22,019 | 8 | $67,394 | Sep 10 | - | false |
| 51 | North Face | - | - | - | $18,078 | 23 | $132,781 | Aug 27 | - | false |
| 52 | Leaves of Grass | - | - | - | $15,558 | 136 | $915,051 | Sep 17 | Eagle Pictures | false |
| 53 | The Karate Kid | - | - | - | $11,684 | 363 | $2,569,778 | Sep 3 | Sony Pictures Releasing | false |
| 54 | Kinky Boots | - | - | - | $8,705 | 1 | $23,729 | Jun 23 | Walt Disney Pictures | false |
| 55 | Miral | - | - | - | $5,140 | 57 | $240,435 | Sep 3 | Eagle Pictures | false |
| 56 | L'estate d'inverno | - | - | - | $4,853 | 4 | $4,853 | Oct 15 | - | false |
| 57 | The American | - | - | - | $4,226 | 277 | $1,482,541 | Sep 10 | United International Pictures | false |
| 58 | The First Beautiful Thing | - | - | - | $3,620 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 59 | Departures | - | - | - | $3,456 | 42 | $868,327 | Apr 9 | - | false |
| 60 | Tutti giù per terra | - | - | - | $1,291 | 1 | $771,254 | Oct 24 | - | false |
