| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Despicable Me | - | - | - | $24,177,379 | 549 | $32,283,987 | Oct 15 | Universal Pictures International (UPI) | false |
| 2 | Paranormal Activity 2 | - | - | - | $13,314,404 | 403 | $17,483,704 | Oct 22 | Paramount Pictures International | false |
| 3 | The Social Network | - | - | - | $12,623,810 | 415 | $16,876,647 | Oct 15 | Sony Pictures Releasing | false |
| 4 | RED | - | - | - | $6,964,700 | 413 | $10,969,022 | Oct 22 | Entertainment One | false |
| 5 | Wall Street: Money Never Sleeps | - | - | - | $6,392,472 | 444 | $6,392,472 | Oct 8 | 20th Century Fox International | false |
| 6 | Saw 3D | - | - | - | $5,776,028 | 382 | $12,878,181 | Oct 29 | Lionsgate | false |
| 7 | Made in Dagenham | - | - | - | $5,306,946 | 357 | $5,714,597 | Oct 1 | Paramount Pictures International | false |
| 8 | Life as We Know It | - | - | - | $5,281,554 | 395 | $5,281,554 | Oct 8 | Warner Bros. | false |
| 9 | Vampires Suck | - | - | - | $4,798,312 | 361 | $4,798,312 | Oct 15 | 20th Century Fox International | false |
| 10 | The Town | - | - | - | $4,760,086 | 326 | $7,484,217 | Sep 24 | Warner Bros. | false |
| 11 | The Other Guys | - | - | - | $4,606,977 | 444 | $12,605,131 | Sep 17 | Sony Pictures Releasing | false |
| 12 | Eat Pray Love | - | - | - | $3,596,470 | 433 | $7,371,485 | Sep 24 | Sony Pictures Releasing | false |
| 13 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $3,503,005 | 482 | $5,282,850 | Oct 22 | Warner Bros. | false |
| 14 | Alpha and Omega | - | - | - | $3,220,413 | 424 | $4,770,519 | Oct 22 | Lionsgate | false |
| 15 | Buried | - | - | - | $2,996,630 | 302 | $2,996,630 | Oct 1 | Icon Film Distribution Australia | false |
| 16 | Toy Story 3 | - | - | - | $2,643,837 | 569 | $116,625,632 | Jul 23 | Walt Disney Pictures | false |
| 17 | The Hole | - | - | - | $2,630,874 | 362 | $4,499,067 | Sep 24 | - | false |
| 18 | Charlie St. Cloud | - | - | - | $2,078,312 | 381 | $2,078,312 | Oct 8 | Universal Pictures International (UPI) | false |
| 19 | Burke and Hare | - | - | - | $1,512,794 | 390 | $3,661,217 | Oct 29 | Entertainment Film Distributors | false |
| 20 | Back to the Future Part II 2010 Re-release | - | - | - | $1,464,772 | 273 | $1,464,772 | Oct 1 | Universal Pictures International (UPI) | false |
| 21 | Easy A | - | - | - | $1,241,489 | 203 | $1,241,489 | Oct 22 | Sony Pictures Releasing | false |
| 22 | Marmaduke | - | - | - | $1,071,013 | 457 | $9,019,305 | Aug 20 | 20th Century Fox International | false |
| 23 | Devil | - | - | - | $1,066,666 | 338 | $4,477,471 | Sep 17 | Universal Pictures International (UPI) | false |
| 24 | Grown Ups | - | - | - | $972,892 | 401 | $12,161,427 | Aug 27 | Sony Pictures Releasing | false |
| 25 | Africa United | - | - | - | $875,298 | 227 | $1,043,690 | Oct 22 | Warner Bros. | false |
| 26 | Mr. Nice | - | - | - | $845,465 | 107 | $1,192,168 | Oct 8 | Entertainment One | false |
| 27 | Enthiran | - | - | - | $785,837 | 34 | $785,837 | Oct 1 | Ayngaran International | false |
| 28 | Takers 2010 Re-release | - | - | - | $686,142 | 151 | $686,142 | Oct 1 | Sony Pictures Releasing | false |
| 29 | The Kids Are All Right | - | - | - | $660,955 | 203 | $2,635,953 | Oct 29 | Universal Pictures International (UPI) | false |
| 30 | Diary of a Wimpy Kid | - | - | - | $622,948 | 372 | $4,283,601 | Aug 27 | 20th Century Fox International | false |
| 31 | Anjaana Anjaani | - | - | - | $577,786 | 54 | $577,786 | Oct 1 | Eros Worldwide | false |
| 32 | Ramona and Beezus | - | - | - | $132,508 | 256 | $768,250 | Oct 22 | 20th Century Fox International | false |
| 33 | Resident Evil: Afterlife | - | - | - | $116,281 | 361 | $7,492,098 | Sep 10 | Sony Pictures Releasing | false |
| 34 | Inception | - | - | - | $100,744 | 472 | $56,566,947 | Jul 16 | Warner Bros. | false |
| 35 | Winter's Bone | - | - | - | $62,682 | 72 | $947,359 | Sep 17 | Artificial Eye | false |
| 36 | Tinker Bell and the Great Fairy Rescue | - | - | - | $51,547 | 236 | $2,396,006 | Aug 13 | Walt Disney Pictures | false |
| 37 | Shrek Forever After | - | - | - | $45,464 | 539 | $51,056,068 | Jul 2 | Paramount Pictures International | false |
| 38 | Scott Pilgrim vs. the World | - | - | - | $45,216 | 414 | $8,445,713 | Aug 27 | Universal Pictures International (UPI) | false |
| 39 | Tamara Drewe | - | - | - | $36,496 | 358 | $4,013,954 | Sep 10 | Momentum Pictures | false |
| 40 | Avatar | - | - | - | $33,694 | 503 | $147,646,580 | Dec 18 | 20th Century Fox International | false |
| 41 | The Karate Kid | - | - | - | $33,159 | 446 | $19,762,070 | Jul 30 | Sony Pictures Releasing | false |
| 42 | Crook: It's Good to Be Bad | - | - | - | $27,345 | 15 | $27,345 | Oct 8 | Bollywood | false |
| 43 | A Town Called Panic | - | - | - | $26,312 | 15 | $26,312 | Oct 8 | Optimum Releasing | false |
| 44 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $22,234 | 480 | $7,570,467 | Aug 6 | Warner Bros. | false |
| 45 | Salt | - | - | - | $18,050 | 413 | $11,321,253 | Aug 20 | Sony Pictures Releasing | false |
| 46 | Dabangg | - | - | - | $14,726 | 41 | $1,247,468 | Sep 10 | Eros Worldwide | false |
| 47 | Restrepo | - | - | - | $14,710 | 6 | $92,016 | Oct 8 | - | false |
| 48 | The Girl Who Played with Fire | - | - | - | $14,025 | 141 | $2,556,558 | Aug 27 | Momentum Pictures | false |
| 49 | Cyrus | - | - | - | $12,940 | 261 | $1,936,218 | Sep 10 | 20th Century Fox International | false |
| 50 | The Illusionist | - | - | - | $11,727 | 42 | $1,417,299 | Aug 20 | Warner Bros. | false |
| 51 | Enter the Void | - | - | - | $11,443 | 9 | $137,307 | Sep 24 | Trinity Filmed Entertainment | false |
| 52 | The Last Exorcism | - | - | - | $11,192 | 322 | $5,874,380 | Sep 3 | Optimum Releasing | false |
| 53 | The Secret in Their Eyes | - | - | - | $10,226 | 16 | $1,166,844 | Aug 13 | Metrodome Distribution | false |
| 54 | Police, Adjective | - | - | - | $9,871 | 10 | $38,268 | Oct 1 | Artificial Eye | false |
| 55 | The Sorcerer's Apprentice | - | - | - | $9,867 | 406 | $5,423,182 | Aug 13 | Walt Disney Pictures | false |
| 56 | Going the Distance | - | - | - | $8,814 | 360 | $2,124,322 | Sep 10 | Warner Bros. | false |
| 57 | Certified Copy | - | - | - | $7,530 | 6 | $497,860 | Sep 3 | Artificial Eye | false |
| 58 | Jackboots on Whitehall | - | - | - | $7,526 | 31 | $7,526 | Oct 8 | Vertigo Films | false |
| 59 | Dinner for Schmucks | - | - | - | $7,217 | 428 | $4,040,902 | Sep 3 | Paramount Pictures International | false |
| 60 | The Expendables | - | - | - | $6,042 | 453 | $15,969,695 | Aug 20 | Lionsgate | false |
| 61 | I'm Still Here | - | - | - | $5,638 | 5 | $98,671 | Sep 17 | Optimum Releasing | false |
| 62 | Peepli Live | - | - | - | $5,635 | 9 | $136,106 | Sep 24 | Artificial Eye | false |
