| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $2,306,994 | 162 | $2,259,877 | Oct 1 | Warner Bros. | false |
| 2 | Eat Pray Love | - | - | - | $729,748 | 25 | $972,593 | Oct 1 | Sony Pictures Releasing | false |
| 3 | Resident Evil: Afterlife | - | - | - | $620,389 | 130 | $3,124,133 | Sep 10 | Sony Pictures Releasing | false |
| 4 | Piranha 3D | - | - | - | $542,432 | 94 | $716,661 | Oct 22 | Cineplex | false |
| 5 | Tinker Bell and the Great Fairy Rescue | - | - | - | $384,290 | 42 | $468,218 | Oct 8 | Walt Disney Pictures | false |
| 6 | Paranormal Activity 2 | - | - | - | $378,473 | 73 | $1,513,758 | Oct 29 | United International Pictures | false |
| 7 | The Town | - | - | - | $368,148 | 47 | $419,746 | Oct 15 | Warner Bros. | false |
| 8 | Wall Street: Money Never Sleeps | - | - | - | $310,231 | 47 | $464,834 | Sep 24 | 20th Century Fox International | false |
| 9 | The Last Airbender | - | - | - | $252,003 | 185 | $3,408,130 | Aug 27 | United International Pictures | false |
| 10 | Inception | - | - | - | $226,052 | 138 | $3,144,672 | Aug 6 | Warner Bros. | false |
| 11 | The Collector | - | - | - | $198,614 | 27 | $283,518 | Oct 15 | Venus | false |
| 12 | Takers 2010 Re-release | - | - | - | $125,380 | 30 | $155,748 | Oct 15 | Sony Pictures Releasing | false |
| 13 | Life as We Know It | - | - | - | $120,442 | 44 | $542,084 | Oct 29 | Warner Bros. | false |
| 14 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $109,465 | 146 | $2,094,843 | Aug 13 | Warner Bros. | false |
| 15 | Going the Distance | - | - | - | $105,825 | 40 | $305,525 | Sep 17 | Warner Bros. | false |
| 16 | Vampires Suck | - | - | - | $100,935 | 21 | $246,857 | Sep 3 | 20th Century Fox International | false |
| 17 | From Paris with Love | - | - | - | $98,407 | 28 | $173,997 | Sep 17 | Babilla Ciné | false |
| 18 | The Box | - | - | - | $75,425 | 23 | $137,384 | Sep 17 | Cine Colombia | false |
| 19 | Despicable Me | - | - | - | $66,907 | 145 | $297 | Apr 27 | Universal Pictures International (UPI) | false |
| 20 | Grown Ups | - | - | - | $64,113 | 50 | $998,569 | Aug 6 | Sony Pictures Releasing | false |
| 21 | Micmacs | - | - | - | $47,209 | 10 | $53,297 | Oct 8 | Sony Pictures Releasing | false |
| 22 | Oceans | - | - | - | $36,317 | 37 | $548,608 | Aug 20 | Cine Colombia | false |
| 23 | Daybreakers | - | - | - | $25,703 | 33 | $132,270 | Sep 3 | Venus | false |
| 24 | The Burning Plain | - | - | - | $18,841 | 10 | $68,252 | Sep 17 | Cine Colombia | false |
| 25 | Halloween II | - | - | - | $15,413 | 22 | $118,926 | Aug 27 | Cine Colombia | false |
| 26 | A Single Man | - | - | - | $13,516 | 11 | $51,644 | Oct 29 | Babilla Ciné | false |
| 27 | City of Life and Death | - | - | - | $11,196 | 3 | $11,196 | Oct 1 | Cineplex | false |
| 28 | Green Zone 2010 Re-release | - | - | - | $10,760 | 25 | $131,978 | Aug 20 | United International Pictures | false |
| 29 | Shrek Forever After | - | - | - | $9,794 | 179 | $6,688,109 | Jul 9 | United International Pictures | false |
