| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $1,054,505 | 74 | $1,246,874 | Oct 7 | Warner Bros. | false |
| 2 | Resident Evil: Afterlife | - | - | - | $580,260 | 73 | $1,353,662 | Sep 15 | Sony Pictures Releasing | false |
| 3 | Inception | - | - | - | $346,842 | 72 | $2,562,565 | Aug 12 | Warner Bros. | false |
| 4 | The Expendables | - | - | - | $345,135 | 33 | $345,135 | Sep 30 | - | false |
| 5 | Salt | - | - | - | $280,361 | 39 | $292,996 | Oct 7 | Sony Pictures Releasing | false |
| 6 | Vampires Suck | - | - | - | $277,565 | 27 | $332,168 | Oct 14 | 20th Century Fox International | false |
| 7 | Wall Street: Money Never Sleeps | - | - | - | $277,250 | 24 | $280,926 | Sep 30 | 20th Century Fox International | false |
| 8 | Eat Pray Love | - | - | - | $269,259 | 17 | $437,918 | Oct 14 | Sony Pictures Releasing | false |
| 9 | Grown Ups | - | - | - | $264,475 | 50 | $611,705 | Sep 9 | Sony Pictures Releasing | false |
| 10 | Qué pena tu vida | - | - | - | $263,996 | 36 | $455,667 | Oct 21 | - | false |
| 11 | Saw 3D | - | - | - | $226,200 | 53 | $683,075 | Oct 28 | - | false |
| 12 | The Last Airbender | - | - | - | $152,378 | 80 | $1,768,877 | Aug 19 | United International Pictures | false |
| 13 | Life as We Know It | - | - | - | $128,827 | 17 | $233,100 | Oct 21 | Warner Bros. | false |
| 14 | Hachi: A Dog's Tale | - | - | - | $116,832 | 14 | $288,311 | Sep 16 | - | false |
| 15 | Nanny McPhee Returns | - | - | - | $110,457 | 29 | $257,244 | Sep 16 | United International Pictures | false |
| 16 | Despicable Me | - | - | - | $105,195 | 70 | $1,426,890 | Jul 29 | United International Pictures | false |
| 17 | It's Alive | - | - | - | $85,186 | 11 | $95,974 | Oct 7 | - | false |
| 18 | Tinker Bell and the Great Fairy Rescue | - | - | - | $81,622 | 22 | $310,178 | Sep 2 | Walt Disney Pictures | false |
| 19 | The Social Network | - | - | - | $77,483 | 27 | $331,704 | Oct 28 | Sony Pictures Releasing | false |
| 20 | The Town | - | - | - | $55,254 | 21 | $152,484 | Oct 28 | Warner Bros. | false |
| 21 | From Paris with Love | - | - | - | $42,393 | 22 | $42,393 | Oct 14 | - | false |
| 22 | Going the Distance | - | - | - | $33,090 | 20 | $192,824 | Sep 2 | Warner Bros. | false |
| 23 | The Fourth Kind | - | - | - | $31,181 | 16 | $177,219 | Aug 26 | Transeuropa | false |
| 24 | The Ghost Writer | - | - | - | $26,801 | 13 | $183,642 | Aug 26 | - | false |
| 25 | Carriers | - | - | - | $18,608 | 12 | $87,976 | Sep 2 | - | false |
| 26 | New York, I Love You 2010 Re-release | - | - | - | $14,554 | 6 | $14,554 | Oct 14 | Transeuropa | false |
| 27 | Vincere | - | - | - | $14,398 | 6 | $34,106 | Oct 21 | - | false |
| 28 | Oceans | - | - | - | $13,805 | 10 | $43,134 | Oct 28 | - | false |
| 29 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $8,175 | 78 | $882,509 | Aug 5 | Warner Bros. | false |
| 30 | Drama | - | - | - | $8,041 | 5 | $33,774 | Oct 7 | - | false |
| 31 | Toy Story 3 | - | - | - | $7,202 | 186 | $8,755,357 | Jun 17 | Walt Disney Pictures | false |
| 32 | Avatar 2010 Special Edition | - | - | - | $4,550 | 31 | $208,715 | Sep 2 | 20th Century Fox International | false |
| 33 | Wild Grass | - | - | - | $3,716 | 3 | $7,079 | Oct 28 | Transeuropa | false |
| 34 | The Meerkats 2010 Re-release | - | - | - | $2,602 | 11 | $4,514 | Oct 28 | - | false |
