| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $218,069 | 17 | $255,935 | Sep 30 | Warner Bros. | false |
| 2 | Resident Evil: Afterlife | - | - | - | $99,568 | 16 | $400,474 | Sep 10 | Sony Pictures Releasing | false |
| 3 | The Twilight Saga: Eclipse | - | - | - | $88,833 | 13 | $160,671 | Sep 23 | Manfer Films | false |
| 4 | Piranha 3D | - | - | - | $71,527 | 6 | $111,962 | Sep 16 | Trade International | false |
| 5 | Vampires Suck | - | - | - | $59,654 | 5 | $71,452 | Oct 7 | 20th Century Fox International | false |
| 6 | Solomon Kane | - | - | - | $47,456 | 5 | $57,968 | Oct 7 | Manfer Films | false |
| 7 | Life as We Know It | - | - | - | $36,764 | 5 | $105,274 | Oct 21 | Warner Bros. | false |
| 8 | Wall Street: Money Never Sleeps | - | - | - | $34,991 | 6 | $49,496 | Sep 23 | 20th Century Fox International | false |
| 9 | The Town | - | - | - | $28,259 | 4 | $34,262 | Oct 14 | Warner Bros. | false |
| 10 | The Other Guys | - | - | - | $20,718 | 4 | $32,469 | Oct 21 | Sony Pictures Releasing | false |
| 11 | Eat Pray Love | - | - | - | $19,968 | 7 | $75,315 | Oct 28 | Sony Pictures Releasing | false |
| 12 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $18,257 | 12 | $273,148 | Aug 19 | Warner Bros. | false |
| 13 | Grown Ups | - | - | - | $13,778 | 8 | $151,699 | Aug 12 | Sony Pictures Releasing | false |
| 14 | Garfield's Pet Force | - | - | - | $13,347 | 3 | $56,251 | Oct 28 | Trade International | false |
| 15 | Halloween II | - | - | - | $13,233 | 4 | $34,719 | Oct 28 | Trade International | false |
| 16 | Paintball | - | - | - | $8,020 | 3 | $8,020 | Oct 21 | - | false |
| 17 | The Last Airbender | - | - | - | $8,005 | 13 | $237,461 | Aug 26 | Paramount Pictures International | false |
| 18 | The Forbidden Kingdom 2010 Re-release | - | - | - | $7,920 | 2 | $12,429 | Sep 16 | Trade International | false |
| 19 | Smother | - | - | - | $6,276 | 2 | $6,276 | Oct 7 | Trade International | false |
| 20 | Igor | - | - | - | $3,893 | 4 | $20,766 | Sep 9 | Trade International | false |
| 21 | Paris 36 | - | - | - | $3,764 | 2 | $3,764 | Sep 30 | - | false |
| 22 | Going the Distance | - | - | - | $3,136 | 4 | $25,694 | Sep 16 | Warner Bros. | false |
| 23 | Inception | - | - | - | $2,505 | 10 | $163,443 | Aug 5 | Warner Bros. | false |
| 24 | Bangkok Dangerous | - | - | - | $1,236 | 2 | $1,236 | Sep 30 | Trade International | false |
| 25 | Swing Vote 2010 Re-release | - | - | - | $1,084 | 2 | $1,084 | Oct 14 | Trade International | false |
| 26 | Carancho | - | - | - | $1,054 | 2 | $1,054 | Oct 21 | - | false |
| 27 | Despicable Me | - | - | - | $1,007 | 14 | $265,912 | Jul 29 | Universal Pictures International (UPI) | false |
| 28 | The Maid | - | - | - | $649 | 1 | $649 | Oct 14 | - | false |
| 29 | A Boyfriend for My Wife | - | - | - | $260 | 1 | $260 | Oct 14 | - | false |
