| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Resident Evil: Afterlife | - | - | - | $1,180,367 | 98 | $1,392,142 | Oct 14 | Sony Pictures Releasing | false |
| 2 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $935,156 | 97 | $1,034,469 | Sep 30 | Warner Bros. | false |
| 3 | Eat Pray Love | - | - | - | $635,532 | 55 | $1,367,393 | Sep 16 | Sony Pictures Releasing | false |
| 4 | Gaturro | - | - | - | $624,950 | 107 | $533,158 | Sep 9 | Distribution Company | false |
| 5 | Buried | - | - | - | $517,299 | 41 | $621,758 | Oct 7 | - | false |
| 6 | No Return | - | - | - | $514,047 | 53 | $537,254 | Sep 30 | Distribution Company | false |
| 7 | Life as We Know It | - | - | - | $467,609 | 43 | $650,507 | Oct 7 | Warner Bros. | false |
| 8 | Saw 3D | - | - | - | $422,116 | 71 | $1,467,534 | Oct 28 | - | false |
| 9 | The Town | - | - | - | $383,667 | 45 | $677,594 | Oct 21 | Warner Bros. | false |
| 10 | The Last Exorcism | - | - | - | $369,520 | 43 | $1,144,364 | Sep 9 | - | false |
| 11 | The Kids Are All Right | - | - | - | $362,097 | 29 | $388,831 | Sep 30 | Alfa Films | false |
| 12 | The Social Network | - | - | - | $352,278 | 51 | $621,292 | Oct 21 | Sony Pictures Releasing | false |
| 13 | Wall Street: Money Never Sleeps | - | - | - | $299,932 | 57 | $533,972 | Sep 23 | 20th Century Fox International | false |
| 14 | Avatar 2010 Special Edition | - | - | - | $266,417 | 50 | $572,030 | Sep 23 | 20th Century Fox International | false |
| 15 | The American | - | - | - | $244,574 | 35 | $298,734 | Oct 14 | Universal Pictures International (UPI) | false |
| 16 | Red | - | - | - | $232,618 | 54 | $691,246 | Oct 28 | Alfa Films | false |
| 17 | I Love You Phillip Morris | - | - | - | $228,750 | 27 | $345,688 | Sep 23 | - | false |
| 18 | Charlie St. Cloud | - | - | - | $198,274 | 35 | $234,966 | Oct 7 | Universal Pictures International (UPI) | false |
| 19 | Toy Story 3 | - | - | - | $154,752 | 177 | $16,026,307 | Jun 17 | Walt Disney Pictures | false |
| 20 | Tinker Bell and the Great Fairy Rescue | - | - | - | $140,438 | 44 | $654,232 | Sep 2 | Walt Disney Pictures | false |
| 21 | Igualita a mí | - | - | - | $121,335 | 104 | $3,539,668 | Aug 12 | Walt Disney Pictures | false |
| 22 | Inception | - | - | - | $118,209 | 119 | $7,439,087 | Jul 29 | Warner Bros. | false |
| 23 | The Man Next Door | - | - | - | $117,180 | 35 | $517,540 | Sep 2 | Primer Plano Film Group | false |
| 24 | The Expendables | - | - | - | $109,005 | 74 | $1,290,333 | Sep 2 | Distribution Company | false |
| 25 | Che: A New Man | - | - | - | $85,602 | 17 | $140,615 | Oct 7 | Distribution Company | false |
| 26 | The Spy Next Door 2010 Re-release | - | - | - | $82,629 | 22 | $170,583 | Oct 21 | - | false |
| 27 | Killers | - | - | - | $60,231 | 32 | $257,923 | Sep 9 | - | false |
| 28 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $45,048 | 112 | $1,415,974 | Aug 19 | Warner Bros. | false |
| 29 | The Descent: Part 2 | - | - | - | $38,085 | 39 | $82,547 | Sep 23 | CDI Films | false |
| 30 | The First Day of the Rest of Your Life | - | - | - | $34,351 | 10 | $45,851 | Oct 21 | Impacto Cine | false |
| 31 | The Dancer and the Thief | - | - | - | $31,304 | 40 | $261,734 | Sep 9 | Walt Disney Pictures | false |
| 32 | The Last Airbender | - | - | - | $27,330 | 115 | $2,760,838 | Aug 12 | Paramount Pictures International | false |
| 33 | Predators | - | - | - | $27,024 | 52 | $553,936 | Aug 12 | 20th Century Fox International | false |
| 34 | Going the Distance | - | - | - | $26,550 | 39 | $315,755 | Sep 2 | Warner Bros. | false |
| 35 | The Missing Lynx 2010 Re-release | - | - | - | $25,393 | 20 | $86,079 | Oct 28 | CDI Films | false |
| 36 | Solitary Man | - | - | - | $25,147 | 21 | $227,969 | Aug 26 | Distribution Company | false |
| 37 | Lula, the Son of Brazil | - | - | - | $25,054 | 19 | $62,536 | Sep 23 | - | false |
| 38 | Everlasting Moments 2010 Re-release | - | - | - | $24,075 | 4 | $30,507 | Oct 7 | Alfa Films | false |
| 39 | Tell No One 2010 Re-release | - | - | - | $21,807 | 4 | $21,807 | Sep 30 | - | false |
| 40 | Mademoiselle Chambon | - | - | - | $19,236 | 11 | $137,726 | Sep 9 | CDI Films | false |
| 41 | Lengua materna | - | - | - | $18,752 | 17 | $26,394 | Oct 21 | Distribution Company | false |
| 42 | Giant | - | - | - | $16,272 | 9 | $16,272 | Oct 14 | Primer Plano Film Group | false |
| 43 | The Hedgehog | - | - | - | $14,031 | 7 | $96,422 | Sep 2 | Impacto Cine | false |
| 44 | Yuki and Nina | - | - | - | $10,272 | 7 | $24,500 | Sep 23 | - | false |
| 45 | Amreeka | - | - | - | $6,877 | 6 | $10,089 | Oct 28 | IFA | false |
| 46 | El rati horror show | - | - | - | $6,066 | 31 | $74,350 | Sep 16 | Distribution Company | false |
| 47 | A Rational Solution | - | - | - | $6,013 | 4 | $11,781 | Oct 28 | Primer Plano Film Group | false |
| 48 | Despicable Me | - | - | - | $5,398 | 146 | $2,878,027 | Jul 29 | Universal Pictures International (UPI) | false |
| 49 | Salt | - | - | - | $4,549 | 59 | $562,778 | Aug 26 | Sony Pictures Releasing | false |
| 50 | Still Walking | - | - | - | $2,552 | 5 | $44,726 | Sep 2 | IFA | false |
| 51 | The Invisible Eye | - | - | - | $2,491 | 12 | $76,158 | Aug 19 | Distribution Company | false |
| 52 | Babies | - | - | - | $2,443 | 5 | $3,659 | Oct 28 | Distribution Company | false |
| 53 | Whiskey with Vodka | - | - | - | $1,618 | 4 | $2,016 | Oct 7 | Primer Plano Film Group | false |
| 54 | The Boys Are Back | - | - | - | $1,497 | 17 | $40,985 | Aug 26 | Alfa Films | false |
| 55 | Pájaros volando | - | - | - | $1,228 | 44 | $450,678 | Aug 5 | Primer Plano Film Group | false |
| 56 | Neither God, Nor Master or Husband | - | - | - | $1,226 | 5 | $3,422 | Sep 23 | Primer Plano Film Group | false |
| 57 | Vincere | - | - | - | $1,091 | 20 | $343,189 | Aug 5 | CDI Films | false |
| 58 | Letters to Juliet | - | - | - | $866 | 17 | $398,187 | Jun 10 | Alfa Films | false |
| 59 | Chloe | - | - | - | $791 | 19 | $160,700 | Aug 12 | Alfa Films | false |
| 60 | The Sorcerer's Apprentice | - | - | - | $556 | 87 | $3,129,367 | Jul 15 | Walt Disney Pictures | false |
| 61 | Shrek Forever After | - | - | - | $407 | 183 | $13,808,538 | Jul 8 | Paramount Pictures International | false |
| 62 | My Days with Gloria | - | - | - | $327 | 16 | $8,434 | Sep 16 | - | false |
| 63 | Padres de la plaza: 10 recorridos posibles | - | - | - | $325 | 2 | $325 | Oct 14 | Primer Plano Film Group | false |
| 64 | London River 2010 Re-release | - | - | - | $222 | 17 | $77,714 | Aug 19 | Primer Plano Film Group | false |
