| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Couples Retreat | - | - | - | $262,064 | 8 | $480,204 | Oct 22 | United International Pictures | false |
| 2 | Up | - | - | - | $189,199 | 17 | $369,387 | Sep 24 | Walt Disney Pictures | false |
| 3 | The Ugly Truth Slovenian Re-release | - | - | - | $81,494 | 7 | $300,486 | Sep 3 | Sony Pictures Releasing | false |
| 4 | The Taking of Pelham 123 | - | - | - | $50,715 | 5 | $54,170 | Oct 8 | Sony Pictures Releasing | false |
| 5 | This Is It | - | - | - | $46,946 | 7 | $123,802 | Oct 28 | Sony Pictures Releasing | false |
| 6 | Orphan | - | - | - | $46,526 | 6 | $73,877 | Oct 1 | Warner Bros. | false |
| 7 | Julie & Julia | - | - | - | $38,817 | 3 | $64,563 | Oct 15 | Sony Pictures Releasing | false |
| 8 | Halloween II | - | - | - | $33,467 | 2 | $37,577 | Oct 8 | - | false |
| 9 | The Final Destination | - | - | - | $33,082 | 10 | $283,637 | Sep 3 | Warner Bros. | false |
| 10 | Surrogates | - | - | - | $31,351 | 8 | $46,543 | Oct 22 | Walt Disney Pictures | false |
| 11 | Saw VI | - | - | - | $29,978 | 5 | $108,583 | Oct 29 | - | false |
| 12 | Whiteout | - | - | - | $29,191 | 4 | $39,155 | Oct 15 | Warner Bros. | false |
| 13 | Fame | - | - | - | $24,145 | 4 | $28,492 | Oct 15 | - | false |
| 14 | City Island | - | - | - | $14,517 | 2 | $16,035 | Oct 8 | - | false |
| 15 | G.I. Joe: The Rise of Cobra | - | - | - | $14,005 | 7 | $34,842 | Oct 1 | United International Pictures | false |
| 16 | Battle for Terra | - | - | - | $13,524 | 4 | $17,630 | Oct 15 | - | false |
| 17 | Public Enemies | - | - | - | $10,033 | 8 | $119,850 | Sep 10 | United International Pictures | false |
| 18 | District 9 | - | - | - | $7,652 | 5 | $42,182 | Sep 17 | - | false |
| 19 | Inglourious Basterds | - | - | - | $6,569 | 7 | $363,637 | Aug 20 | United International Pictures | false |
| 20 | Coco Before Chanel | - | - | - | $4,871 | 4 | $109,091 | Aug 27 | - | false |
| 21 | Funny People | - | - | - | $3,721 | 6 | $41,552 | Sep 17 | United International Pictures | false |
