| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $16,877,278 | 652 | $22,494,067 | Oct 15 | Walt Disney Pictures | false |
| 2 | Inglourious Basterds | - | - | - | $12,713,629 | 465 | $13,380,924 | Oct 2 | United International Pictures | false |
| 3 | Baaria | - | - | - | $10,014,451 | 527 | $14,686,170 | Sep 25 | Medusa Distribuzione | false |
| 4 | The Imaginarium of Doctor Parnassus | - | - | - | $6,331,254 | 283 | $11,119,996 | Oct 23 | - | false |
| 5 | G-Force | - | - | - | $3,435,092 | 342 | $5,891,041 | Sep 24 | Walt Disney Pictures | false |
| 6 | Whatever Works | - | - | - | $3,265,068 | 329 | $7,399,626 | Sep 18 | Medusa Distribuzione | false |
| 7 | Just Married | - | - | - | $2,857,780 | 378 | $4,814,840 | Oct 23 | United International Pictures | false |
| 8 | Fame | - | - | - | $2,462,242 | 337 | $2,462,242 | Oct 9 | Lucky Red | false |
| 9 | This Is It | - | - | - | $2,154,471 | 519 | $6,157,165 | Oct 28 | Sony Pictures Releasing | false |
| 10 | Love 14 | - | - | - | $2,082,601 | 423 | $4,665,465 | Oct 30 | Medusa Distribuzione | false |
| 11 | Ice Age: Dawn of the Dinosaurs | - | - | - | $1,785,566 | 812 | $43,860,019 | Aug 28 | 20th Century Fox International | false |
| 12 | Julie & Julia | - | - | - | $1,769,149 | 153 | $3,006,094 | Oct 23 | Sony Pictures Releasing | false |
| 13 | Red Cliff | - | - | - | $1,445,308 | 248 | $1,872,513 | Oct 23 | Eagle Pictures | false |
| 14 | Brüno | - | - | - | $1,383,350 | 239 | $1,755,582 | Oct 23 | Medusa Distribuzione | false |
| 15 | District 9 | - | - | - | $1,378,635 | 263 | $2,741,154 | Sep 25 | Sony Pictures Releasing | false |
| 16 | Lo spazio bianco | - | - | - | $1,250,318 | 157 | $1,448,733 | Oct 16 | 01 Distribution | false |
| 17 | Sword of War | - | - | - | $1,189,887 | 267 | $1,189,887 | Oct 9 | 01 Distribution | false |
| 18 | The Double Hour | - | - | - | $1,134,754 | 226 | $1,182,547 | Oct 9 | Medusa Distribuzione | false |
| 19 | Halloween II | - | - | - | $1,128,075 | 207 | $1,146,982 | Oct 16 | Sony Pictures Releasing | false |
| 20 | Orphan | - | - | - | $1,127,360 | 156 | $1,283,140 | Oct 16 | Warner Bros. | false |
| 21 | My Life in Ruins | - | - | - | $1,081,008 | 127 | $1,106,259 | Oct 9 | - | false |
| 22 | The Girl Who Played with Fire | - | - | - | $1,045,537 | 250 | $2,055,044 | Sep 25 | BIM Distribuzione | false |
| 23 | Purple Sea | - | - | - | $809,020 | 101 | $1,018,995 | Oct 16 | Medusa Distribuzione | false |
| 24 | The Taking of Pelham 123 | - | - | - | $770,577 | 322 | $3,478,075 | Sep 18 | Sony Pictures Releasing | false |
| 25 | The Time Traveler's Wife | - | - | - | $710,243 | 190 | $710,243 | Oct 2 | 01 Distribution | false |
| 26 | Taking Woodstock | - | - | - | $597,718 | 97 | $646,308 | Oct 9 | BIM Distribuzione | false |
| 27 | The Proposal | - | - | - | $510,461 | 354 | $6,416,839 | Sep 3 | Walt Disney Pictures | false |
| 28 | Whiteout | - | - | - | $469,565 | 116 | $469,565 | Oct 2 | Warner Bros. | false |
| 29 | Where the Wild Things Are | - | - | - | $413,036 | 262 | $898,743 | Oct 30 | Warner Bros. | false |
| 30 | The Big Dream | - | - | - | $354,976 | 402 | $4,322,939 | Sep 11 | Medusa Distribuzione | false |
| 31 | Happily N'ever After 2: Snow White: Another Bite at the Apple | - | - | - | $337,429 | 124 | $337,429 | Oct 2 | Eagle Pictures | false |
| 32 | Lebanon | - | - | - | $277,390 | 47 | $453,150 | Oct 23 | BIM Distribuzione | false |
| 33 | Knowing | - | - | - | $274,427 | 402 | $6,673,881 | Sep 4 | Eagle Pictures | false |
| 34 | Capitalism: A Love Story | - | - | - | $215,090 | 99 | $568,310 | Oct 30 | Mikado Film | false |
| 35 | Funny People | - | - | - | $196,082 | 4 | $196,082 | Oct 16 | United International Pictures | false |
| 36 | The Lawyers - A German Story | - | - | - | $174,395 | 49 | $717,625 | Oct 30 | Lucky Red | false |
| 37 | Ricky | - | - | - | $170,496 | 30 | $170,496 | Oct 9 | Teodora Film | false |
| 38 | G.I. Joe: The Rise of Cobra | - | - | - | $85,306 | 341 | $4,021,992 | Sep 11 | United International Pictures | false |
| 39 | Tales from the Golden Age | - | - | - | $79,767 | 15 | $156,664 | Sep 18 | - | false |
| 40 | Bandslam | - | - | - | $49,878 | 178 | $319,719 | Sep 25 | Eagle Pictures | false |
| 41 | I, Don Giovanni | - | - | - | $47,734 | 21 | $98,827 | Oct 21 | Lucky Red | false |
| 42 | Cosmonaut | - | - | - | $40,201 | 57 | $476,246 | Sep 11 | Fandango | false |
| 43 | My Neighbor Totoro 2009 Re-release | - | - | - | $38,269 | 65 | $381,161 | Sep 18 | Lucky Red | false |
| 44 | The Artist | - | - | - | $26,900 | 20 | $26,900 | Oct 2 | - | false |
| 45 | Turtle: The Incredible Journey | - | - | - | $15,206 | 15 | $25,049 | Oct 23 | - | false |
| 46 | A Summer in Genoa | - | - | - | $15,034 | 6 | $97,471 | Oct 16 | - | false |
| 47 | Tinker Bell and the Lost Treasure | - | - | - | $6,794 | 24 | $65,942 | Oct 2 | Walt Disney Pictures | false |
| 48 | The Boat That Rocked | - | - | - | $5,616 | 99 | $1,383,446 | Jun 12 | United International Pictures | false |
| 49 | Di me cosa ne sai | - | - | - | $3,994 | 4 | $12,884 | Oct 16 | - | false |
