| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Agora | - | - | - | $22,231,353 | 478 | $29,609,470 | Oct 9 | 20th Century Fox International | false |
| 2 | G-Force | - | - | - | $9,664,494 | 482 | $12,966,370 | Oct 9 | Walt Disney Pictures | false |
| 3 | [Rec]² | - | - | - | $7,380,375 | 356 | $7,684,043 | Oct 2 | Filmax | false |
| 4 | Inglourious Basterds | - | - | - | $5,908,872 | 482 | $15,418,489 | Sep 18 | United International Pictures | false |
| 5 | The Ugly Truth | - | - | - | $5,284,255 | 360 | $7,800,185 | Oct 16 | Sony Pictures Releasing | false |
| 6 | Whatever Works | - | - | - | $4,375,116 | 196 | $5,590,384 | Oct 2 | TriPictures | false |
| 7 | Vicky the Viking | - | - | - | $4,320,313 | 358 | $5,237,616 | Oct 2 | Aurum Films | false |
| 8 | Surrogates | - | - | - | $3,464,461 | 320 | $6,176,221 | Sep 25 | Walt Disney Pictures | false |
| 9 | The Girl Who Played with Fire | - | - | - | $3,217,940 | 360 | $7,772,456 | Oct 23 | Vértigo Films | false |
| 10 | Orphan | - | - | - | $2,034,084 | 264 | $2,713,843 | Oct 16 | Warner Bros. | false |
| 11 | Carriers | - | - | - | $1,118,819 | 165 | $1,400,982 | Oct 16 | DeAPlaneta | false |
| 12 | District 9 | - | - | - | $856,533 | 357 | $7,023,330 | Sep 11 | Sony Pictures Releasing | false |
| 13 | Jennifer's Body | - | - | - | $740,993 | 265 | $1,462,153 | Sep 25 | 20th Century Fox International | false |
| 14 | New York, I Love You | - | - | - | $686,157 | 100 | $935,198 | Oct 16 | TriPictures | false |
| 15 | Up | - | - | - | $646,749 | 603 | $37,052,520 | Jul 30 | Walt Disney Pictures | false |
| 16 | Fat People | - | - | - | $598,307 | 176 | $2,664,834 | Sep 11 | Alta Films | false |
| 17 | 500 Days of Summer | - | - | - | $584,173 | 151 | $1,541,806 | Oct 23 | 20th Century Fox International | false |
| 18 | He's Just Not That Into You | - | - | - | $557,275 | 336 | $6,788,630 | Sep 3 | TriPictures | false |
| 19 | Toy Story 2009 Re-release | - | - | - | $498,479 | 73 | $1,195,405 | Oct 23 | Walt Disney Pictures | false |
| 20 | OceanWorld | - | - | - | $475,674 | 118 | $938,228 | Sep 25 | Wanda Visión S.A. | false |
| 21 | My Bloody Valentine | - | - | - | $428,583 | 310 | $4,593,087 | Sep 11 | TriPictures | false |
| 22 | The Imaginarium of Doctor Parnassus | - | - | - | $424,359 | 71 | $1,342,851 | Oct 23 | Sony Pictures Releasing | false |
| 23 | The Informant! | - | - | - | $381,685 | 104 | $789,433 | Sep 25 | Warner Bros. | false |
| 24 | Me Too | - | - | - | $360,164 | 100 | $440,170 | Oct 16 | Golem Distribución | false |
| 25 | Katyn | - | - | - | $311,755 | 28 | $373,978 | Oct 9 | Karma Films | false |
| 26 | Moon | - | - | - | $305,910 | 30 | $451,359 | Oct 9 | Sony Pictures Releasing | false |
| 27 | Paris | - | - | - | $293,284 | 50 | $317,716 | Oct 9 | Vértigo Films | false |
| 28 | The Hangover | - | - | - | $287,003 | 327 | $9,374,796 | Aug 14 | Warner Bros. | false |
| 29 | The Girl with the Dragon Tattoo | - | - | - | $262,791 | 283 | $13,727,644 | May 29 | Vértigo Films | false |
| 30 | After | - | - | - | $220,547 | 123 | $330,713 | Oct 23 | Alta Films | false |
| 31 | Aliens in the Attic | - | - | - | $173,262 | 324 | $5,465,811 | Aug 14 | 20th Century Fox International | false |
| 32 | Year One | - | - | - | $172,487 | 222 | $4,173,713 | Aug 28 | Sony Pictures Releasing | false |
| 33 | Map of the Sounds of Tokyo | - | - | - | $154,294 | 170 | $2,990,991 | Aug 28 | Alta Films | false |
| 34 | Case 39 | - | - | - | $130,168 | 221 | $3,837,870 | Aug 28 | Paramount Pictures International | false |
| 35 | Frozen River | - | - | - | $122,850 | 36 | $722,067 | Sep 4 | Sagrera TV | false |
| 36 | Bandslam | - | - | - | $119,593 | 125 | $749,455 | Sep 11 | Aurum Films | false |
| 37 | Shorts | - | - | - | $114,319 | 165 | $1,754,478 | Aug 28 | Warner Bros. | false |
| 38 | The Limits of Control | - | - | - | $91,253 | 6 | $95,120 | Oct 2 | TriPictures | false |
| 39 | The Cloud Painting Machine | - | - | - | $81,227 | 30 | $170,809 | Oct 2 | Paramount Pictures International | false |
| 40 | Giant | - | - | - | $55,787 | 16 | $58,207 | Oct 2 | Golem Distribución | false |
| 41 | Eden Is West | - | - | - | $52,762 | 18 | $99,470 | Oct 23 | Wanda Visión S.A. | false |
| 42 | Let's Get Lost 2009 Re-release | - | - | - | $41,879 | 3 | $99,046 | Sep 18 | Avalon | false |
| 43 | La Felicidad Completa | - | - | - | $38,839 | 50 | $38,839 | Oct 2 | Barton Films | false |
| 44 | Ice Age: Dawn of the Dinosaurs | - | - | - | $35,667 | 663 | $32,142,485 | Jul 2 | 20th Century Fox International | false |
| 45 | The Frost | - | - | - | $35,429 | 18 | $71,023 | Oct 16 | Independent Films | false |
| 46 | Departures | - | - | - | $34,940 | 35 | $726,311 | Jul 3 | Golem Distribución | false |
| 47 | Imagine That | - | - | - | $31,351 | 20 | $35,573 | Oct 9 | Paramount Pictures International | false |
| 48 | Mid-August Lunch | - | - | - | $24,794 | 31 | $1,272,844 | May 22 | Alta Films | false |
| 49 | Bullying | - | - | - | $22,716 | 31 | $26,486 | Oct 23 | Filmax | false |
| 50 | Still Walking | - | - | - | $22,127 | 4 | $386,649 | Jun 5 | Golem Distribución | false |
| 51 | Spread | - | - | - | $21,874 | 203 | $2,052,392 | Aug 28 | Aurum Films | false |
| 52 | Guts | - | - | - | $19,152 | 166 | $1,023,161 | Sep 4 | Sony Pictures Releasing | false |
| 53 | Antichrist | - | - | - | $17,202 | 80 | $770,255 | Aug 21 | Golem Distribución | false |
| 54 | The September Issue | - | - | - | $14,942 | 5 | $26,073 | Sep 25 | Avalon | false |
| 55 | The Damned United | - | - | - | $14,643 | 30 | $14,643 | Oct 2 | Sony Pictures Releasing | false |
| 56 | Public Enemies | - | - | - | $12,748 | 460 | $10,686,582 | Aug 14 | United International Pictures | false |
| 57 | Mònica del Raval | - | - | - | $11,040 | 4 | $11,893 | Oct 9 | - | false |
| 58 | Ex | - | - | - | $10,589 | 158 | $1,115,617 | Jul 24 | Notro Films | false |
| 59 | Hollywood contra Franco | - | - | - | $9,939 | 12 | $11,361 | Oct 16 | - | false |
| 60 | A French Gigolo | - | - | - | $8,524 | 50 | $266,126 | Sep 4 | Vértigo Films | false |
| 61 | Funny People | - | - | - | $7,632 | 182 | $980,798 | Sep 4 | United International Pictures | false |
| 62 | Shevernatze un ángel corrupto | - | - | - | $6,618 | 55 | $9,285 | Oct 23 | - | false |
| 63 | 12 Rounds | - | - | - | $6,231 | 30 | $92,150 | Sep 11 | 20th Century Fox International | false |
| 64 | The First Day of the Rest of Your Life | - | - | - | $5,738 | 47 | $856,174 | Jun 19 | - | false |
| 65 | Íntimos y extraños. 3 historias y 1/2 | - | - | - | $5,402 | 11 | $5,402 | Oct 16 | - | false |
| 66 | Harry Potter and the Half-Blood Prince | - | - | - | $5,379 | 589 | $20,813,480 | Jul 15 | Warner Bros. | false |
| 67 | Checkpoint Rock: Songs from Palestine | - | - | - | $5,369 | 4 | $5,430 | Oct 16 | Barton Films | false |
| 68 | Another Man | - | - | - | $4,615 | 5 | $4,615 | Oct 9 | - | false |
| 69 | Màscares | - | - | - | $4,393 | 4 | $4,393 | Oct 2 | Wanda Visión S.A. | false |
| 70 | The Taking of Pelham 123 | - | - | - | $4,341 | 401 | $8,867,740 | Jul 24 | Sony Pictures Releasing | false |
| 71 | Gamer | - | - | - | $3,494 | 302 | $2,049,947 | Sep 4 | - | false |
| 72 | I Love You, Beth Cooper | - | - | - | $2,558 | 30 | $47,255 | Sep 18 | 20th Century Fox International | false |
| 73 | Como Fazer Um Filme de Amor | - | - | - | $2,384 | 3 | $2,748 | Sep 25 | - | false |
| 74 | Tear This Heart Out | - | - | - | $2,087 | 80 | $509,547 | Jul 24 | Wanda Visión S.A. | false |
| 75 | Angels & Demons | - | - | - | $1,868 | 699 | $21,944,084 | May 15 | Sony Pictures Releasing | false |
| 76 | Owl and the Sparrow | - | - | - | $1,765 | 10 | $118,354 | Jul 24 | - | false |
| 77 | The Hanged Man | - | - | - | $1,708 | 119 | $473,546 | Jan 30 | Sony Pictures Releasing | false |
| 78 | Gran Torino | - | - | - | $1,630 | 263 | $19,038,938 | Mar 6 | Warner Bros. | false |
| 79 | The Drummer | - | - | - | $1,575 | 3 | $35,938 | Sep 11 | Karma Films | false |
| 80 | Flores negras | - | - | - | $1,431 | 105 | $157,325 | Sep 18 | Filmax | false |
| 81 | Satin Rouge 2009 Re-release | - | - | - | $1,370 | 4 | $118,389 | Jul 31 | Karma Films | false |
| 82 | Lilly the Witch: The Dragon and the Magic Book | - | - | - | $1,309 | 2,642 | $3,494,942 | Jun 12 | Walt Disney Pictures | false |
| 83 | Three Days with the Family | - | - | - | $1,194 | 30 | $382,763 | Jun 26 | - | false |
| 84 | Brüno | - | - | - | $976 | 310 | $2,542,344 | Jul 10 | Sony Pictures Releasing | false |
| 85 | Obsessed | - | - | - | $819 | 202 | $1,914,828 | Jun 19 | Sony Pictures Releasing | false |
| 86 | LOL (Laughing Out Loud) | - | - | - | $731 | 191 | $847,737 | Jun 26 | Alta Films | false |
| 87 | Disgrace | - | - | - | $650 | 6 | $400,184 | Jul 31 | Golem Distribución | false |
| 88 | The Life Before Her Eyes | - | - | - | $630 | 25 | $141,603 | Aug 21 | Manga Entertainment | false |
| 89 | The Proposal | - | - | - | $447 | 350 | $5,959,363 | Jul 9 | Walt Disney Pictures | false |
| 90 | My Life in Ruins | - | - | - | $223 | 207 | $1,842,519 | Aug 7 | Manga Entertainment | false |
| 91 | V.O.S. | - | - | - | $96 | 24 | $272,271 | Jul 10 | Alta Films | false |
| 92 | Land of the Lost | - | - | - | $95 | 95 | $513,239 | Aug 21 | United International Pictures | false |
