| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Cloudy with a Chance of Meatballs | - | - | - | $6,802,666 | 256 | $7,801,829 | Oct 2 | Sony Pictures Releasing | false |
| 2 | The Ugly Truth | - | - | - | $3,887,197 | 164 | $7,286,581 | Sep 18 | Sony Pictures Releasing | false |
| 3 | Inglourious Basterds | - | - | - | $2,257,868 | 179 | $5,050,972 | Oct 9 | Universal Pictures International (UPI) | false |
| 4 | Up | - | - | - | $2,150,412 | 329 | $10,528,510 | Sep 4 | Walt Disney Pictures | false |
| 5 | District 9 | - | - | - | $2,126,802 | 211 | $2,606,642 | Oct 16 | Sony Pictures Releasing | false |
| 6 | The Hangover | - | - | - | $1,662,701 | 214 | $8,911,937 | Aug 21 | Warner Bros. | false |
| 7 | Time of Fear | - | - | - | $1,404,671 | 186 | $1,469,181 | Oct 2 | Sony Pictures Releasing | false |
| 8 | So Normal 2: The Craziest Night Ever | - | - | - | $1,312,075 | 437 | $10,747,823 | Aug 28 | - | false |
| 9 | This Is It | - | - | - | $1,095,400 | 202 | $3,603,288 | Oct 28 | Sony Pictures Releasing | false |
| 10 | Surrogates | - | - | - | $1,041,264 | 118 | $1,838,881 | Oct 23 | Walt Disney Pictures | false |
| 11 | The Taking of Pelham 123 | - | - | - | $722,787 | 181 | $4,246,493 | Sep 4 | Sony Pictures Releasing | false |
| 12 | Gamer | - | - | - | $603,074 | 102 | $603,074 | Oct 2 | - | false |
| 13 | The Assailant | - | - | - | $488,537 | 145 | $2,019,443 | Oct 30 | Walt Disney Pictures | false |
| 14 | 9 | - | - | - | $475,011 | 141 | $475,011 | Oct 9 | PlayArte Pictures | false |
| 15 | The Time Traveler's Wife | - | - | - | $420,696 | 139 | $1,395,325 | Oct 16 | PlayArte Pictures | false |
| 16 | Whiteout | - | - | - | $285,899 | 49 | $285,899 | Oct 2 | Warner Bros. | false |
| 17 | The Rebound | - | - | - | $264,889 | 85 | $1,053,363 | Oct 16 | - | false |
| 18 | My Sister's Keeper | - | - | - | $259,022 | 94 | $1,175,619 | Sep 11 | PlayArte Pictures | false |
| 19 | Aliens in the Attic | - | - | - | $247,338 | 84 | $493,214 | Sep 25 | 20th Century Fox International | false |
| 20 | Spread | - | - | - | $222,216 | 52 | $602,656 | Sep 25 | - | false |
| 21 | G-Force | - | - | - | $186,831 | 304 | $4,411,008 | Aug 14 | Walt Disney Pictures | false |
| 22 | The Dolphin: Story of a Dreamer | - | - | - | $170,718 | 64 | $289,656 | Oct 9 | 20th Century Fox International | false |
| 23 | The Informant! | - | - | - | $135,977 | 32 | $454,448 | Oct 16 | Warner Bros. | false |
| 24 | Orphan | - | - | - | $131,935 | 81 | $814,780 | Sep 4 | Warner Bros. | false |
| 25 | The Proposal | - | - | - | $118,544 | 159 | $7,438,656 | Jul 10 | Walt Disney Pictures | false |
| 26 | Sorority Row | - | - | - | $103,793 | 80 | $297,916 | Sep 25 | Paris Filmes | false |
| 27 | Two Lovers | - | - | - | $95,506 | 50 | $667,097 | Aug 28 | PlayArte Pictures | false |
| 28 | Herbert de Perto | - | - | - | $90,293 | 31 | $90,293 | Oct 9 | - | false |
| 29 | My Life in Ruins | - | - | - | $62,769 | 121 | $812,423 | Sep 11 | - | false |
| 30 | Easy Virtue | - | - | - | $50,466 | 6 | $201,042 | Oct 23 | Sony Pictures Releasing | false |
| 31 | Shorts | - | - | - | $40,906 | 61 | $287,452 | Aug 28 | Warner Bros. | false |
| 32 | Ice Age: Dawn of the Dinosaurs | - | - | - | $40,280 | 710 | $45,373,371 | Jul 1 | 20th Century Fox International | false |
| 33 | Che: Part Two | - | - | - | $39,613 | 34 | $102,281 | Sep 18 | Europa Filmes | false |
| 34 | Drag Me to Hell | - | - | - | $12,847 | 194 | $1,790,906 | Aug 14 | Universal Pictures International (UPI) | false |
| 35 | Brüno | - | - | - | $12,497 | 89 | $1,170,855 | Aug 14 | Sony Pictures Releasing | false |
| 36 | Bandslam | - | - | - | $10,251 | 82 | $144,436 | Sep 11 | Paris Filmes | false |
| 37 | Adrift | - | - | - | $7,261 | 42 | $471,448 | Jul 31 | Universal Pictures International (UPI) | false |
| 38 | Diary of a Nymphomaniac | - | - | - | $6,492 | 34 | $47,714 | Sep 25 | PlayArte Pictures | false |
| 39 | Time of Peace | - | - | - | $5,648 | 53 | $428,328 | Aug 14 | - | false |
| 40 | The Invisible Woman | - | - | - | $5,443 | 221 | $11,436,322 | Jun 5 | Warner Bros. | false |
| 41 | The Story of Me | - | - | - | $2,666 | 95 | $592,924 | Aug 7 | Warner Bros. | false |
| 42 | Harry Potter and the Half-Blood Prince | - | - | - | $2,426 | 702 | $20,240,271 | Jul 17 | Warner Bros. | false |
| 43 | G.I. Joe: The Rise of Cobra | - | - | - | $2,295 | 369 | $3,517,203 | Aug 7 | Paramount Pictures International | false |
| 44 | The International | - | - | - | $855 | 51 | $625,835 | Jun 19 | Sony Pictures Releasing | false |
| 45 | Hannah Montana: The Movie | - | - | - | $70 | 196 | $2,796,536 | Jun 11 | Walt Disney Pictures | false |
