| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Mamma Mia! | - | - | - | $9,205,756 | 400 | $12,919,298 | Oct 3 | United International Pictures | false |
| 2 | WALL·E | - | - | - | $7,283,505 | 592 | $12,210,993 | Oct 17 | Walt Disney Pictures | false |
| 3 | Vicky Cristina Barcelona | - | - | - | $4,985,330 | 383 | $8,124,300 | Oct 17 | Medusa Distribuzione | false |
| 4 | No Problem | - | - | - | $4,481,608 | 423 | $4,837,672 | Oct 10 | Medusa Distribuzione | false |
| 5 | You Don't Mess with the Zohan | - | - | - | $3,473,667 | 222 | $3,849,845 | Oct 3 | Sony Pictures Releasing | false |
| 6 | Disaster Movie | - | - | - | $2,933,573 | 234 | $2,946,110 | Oct 10 | Eagle Pictures | false |
| 7 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $2,870,665 | 466 | $7,983,188 | Sep 26 | Universal Pictures International (UPI) | false |
| 8 | Righteous Kill | - | - | - | $2,388,428 | 362 | $4,578,190 | Sep 26 | 01 Distribution | false |
| 9 | Tropic Thunder | - | - | - | $2,186,762 | 297 | $4,624,397 | Oct 24 | Universal Pictures International (UPI) | false |
| 10 | The Mist | - | - | - | $1,891,676 | 207 | $1,902,311 | Oct 10 | Lucky Red | false |
| 11 | Babylon A.D. | - | - | - | $1,842,920 | 254 | $3,374,069 | Oct 24 | Moviemax | false |
| 12 | Burn After Reading | - | - | - | $1,618,380 | 421 | $8,734,151 | Sep 19 | Medusa Distribuzione | false |
| 13 | The Class | - | - | - | $1,389,604 | 108 | $2,223,910 | Oct 10 | Mikado Film | false |
| 14 | Miracle at St. Anna | - | - | - | $1,343,616 | 263 | $1,363,754 | Oct 3 | 01 Distribution | false |
| 15 | Hancock | - | - | - | $1,154,861 | 678 | $17,819,261 | Sep 12 | Sony Pictures Releasing | false |
| 16 | The Women | - | - | - | $1,092,389 | 214 | $1,108,539 | Oct 10 | BIM Distribuzione | false |
| 17 | Noah's Ark | - | - | - | $979,939 | 233 | $1,056,897 | Oct 3 | Eagle Pictures | false |
| 18 | The Man Who Loves | - | - | - | $837,512 | 184 | $1,997,433 | Oct 24 | Medusa Distribuzione | false |
| 19 | Albakiara | - | - | - | $824,863 | 278 | $1,031,340 | Oct 24 | Mikado Film | false |
| 20 | Mid-August Lunch | - | - | - | $588,729 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 21 | Mirrors | - | - | - | $483,510 | 178 | $511,156 | Oct 3 | 20th Century Fox International | false |
| 22 | Giovanna's Father | - | - | - | $413,778 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 23 | Paris | - | - | - | $377,591 | 65 | $695,130 | Sep 26 | BIM Distribuzione | false |
| 24 | Fireflies in the Garden 2008 Re-release | - | - | - | $315,508 | 174 | $910,176 | Sep 26 | Medusa Distribuzione | false |
| 25 | Bonneville | - | - | - | $270,868 | 58 | $342,753 | Oct 17 | Teodora Film | false |
| 26 | Lecture 21 | - | - | - | $257,647 | 48 | $338,622 | Oct 17 | 01 Distribution | false |
| 27 | Lorna's Silence | - | - | - | $194,734 | 39 | $525,788 | Sep 19 | Lucky Red | false |
| 28 | The Hurt Locker | - | - | - | $128,420 | 70 | $234,231 | Oct 10 | Warner Bros. | false |
| 29 | The Seed of Discord | - | - | - | $106,201 | 216 | $1,492,100 | Sep 5 | Medusa Distribuzione | false |
| 30 | Pa-ra-da | - | - | - | $62,833 | 52 | $305,344 | Sep 19 | 01 Distribution | false |
| 31 | Control | - | - | - | $36,556 | 10 | $99,924 | Oct 24 | Metacinema | false |
| 32 | The Wind Blows Round | - | - | - | $32,246 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 33 | Three Monkeys | - | - | - | $27,166 | 38 | $180,593 | Sep 12 | BIM Distribuzione | false |
| 34 | Capitan Basilico | - | - | - | $23,652 | 5 | $23,652 | Oct 10 | - | false |
| 35 | A Perfect Day | - | - | - | $18,860 | 403 | $4,212,962 | Sep 5 | 01 Distribution | false |
| 36 | High School Musical 3: Senior Year | - | - | - | $18,332 | 493 | $12,738,501 | Oct 31 | Walt Disney Pictures | false |
| 37 | The Chronicles of Narnia: Prince Caspian | - | - | - | $16,721 | 601 | $10,800,873 | Aug 14 | Walt Disney Pictures | false |
| 38 | Gomorrah | - | - | - | $16,326 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 39 | Machan | - | - | - | $16,060 | 48 | $222,580 | Sep 12 | Mikado Film | false |
| 40 | Everyone's Hero | - | - | - | $15,492 | 139 | $483,144 | Sep 12 | Medusa Distribuzione | false |
| 41 | La rabbia di Pasolini | - | - | - | $15,428 | 16 | $125,866 | Sep 5 | Istituto Luce | false |
| 42 | Step Brothers | - | - | - | $13,905 | 10 | $13,905 | Oct 17 | Sony Pictures Releasing | false |
| 43 | Star Wars: The Clone Wars | - | - | - | $13,008 | 198 | $453,441 | Sep 19 | Warner Bros. | false |
| 44 | Il Divo | - | - | - | $9,049 | 358 | $8,517,653 | May 28 | Lucky Red | false |
| 45 | Virgin Territory | - | - | - | $6,771 | 175 | $1,567,471 | Sep 5 | Eagle Pictures | false |
| 46 | Billo - Il Grand Dakhaar | - | - | - | $6,086 | 3 | $26,106 | Sep 19 | - | false |
| 47 | Meet Dave | - | - | - | $4,963 | 307 | $2,361,245 | Aug 22 | 20th Century Fox International | false |
| 48 | Birdwatchers | - | - | - | $4,644 | 56 | $482,815 | Sep 2 | 01 Distribution | false |
| 49 | Gravehopping | - | - | - | $3,565 | 2 | $43,057 | Jul 4 | - | false |
| 50 | The Dark Knight | - | - | - | $3,537 | 616 | $13,871,401 | Jul 23 | Warner Bros. | false |
| 51 | La fabbrica dei tedeschi | - | - | - | $3,330 | 3 | $20,844 | Sep 12 | Istituto Luce | false |
| 52 | Ex Drummer | - | - | - | $3,229 | 7 | $83,700 | Oct 3 | L'Altrofilm | false |
| 53 | Haïti chérie | - | - | - | $2,945 | 1 | $7,680 | Sep 26 | - | false |
| 54 | La perfezionista | - | - | - | $2,799 | 11 | $2,799 | Oct 17 | - | false |
| 55 | Alexandra | - | - | - | $2,702 | 7 | $77,404 | May 30 | - | false |
| 56 | Jimmy della collina | - | - | - | $2,621 | 5 | $71,846 | Apr 4 | Aranciafilm | false |
| 57 | The Year My Parents Went on Vacation | - | - | - | $1,711 | 27 | $384,887 | Jun 6 | Lucky Red | false |
| 58 | The Demons of St. Petersburg | - | - | - | $1,328 | 110 | $1,409,678 | Apr 24 | 01 Distribution | false |
| 59 | Little Boy Red | - | - | - | $1,134 | 6 | $227,801 | Nov 16 | - | false |
| 60 | Taken | - | - | - | $1,025 | 198 | $2,091,060 | Aug 14 | 20th Century Fox International | false |
| 61 | Tuttifrutti | - | - | - | $1,021 | 21 | $103,007 | May 16 | - | false |
| 62 | The Nightmare Before Christmas 1994 Re-release | - | - | - | $986 | 1 | $2,038,691 | Nov 30 | Walt Disney Pictures | false |
| 63 | La Fontana di moru' | - | - | - | $941 | 1 | $941 | Oct 17 | - | false |
| 64 | Salvador | - | - | - | $934 | 40 | $120,145 | Apr 27 | Istituto Luce | false |
| 65 | La rabbia | - | - | - | $854 | 15 | $383,975 | Feb 29 | L'Altrofilm | false |
| 66 | Dr. Plonk | - | - | - | $834 | 4 | $7,792 | Jul 4 | Fandango | false |
| 67 | The Band's Visit | - | - | - | $662 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 68 | The Night of the Sunflowers | - | - | - | $650 | 11 | $67,192 | Jun 13 | Istituto Luce | false |
| 69 | Eldorado | - | - | - | $632 | 17 | $41,639 | Aug 29 | Archibald | false |
| 70 | The Rocker | - | - | - | $613 | 149 | $426,236 | Sep 19 | 20th Century Fox International | false |
| 71 | Then She Found Me | - | - | - | $562 | 142 | $940,111 | Jun 6 | Medusa Distribuzione | false |
| 72 | La canarina assassinata | - | - | - | $527 | 2 | $8,434 | Sep 26 | - | false |
| 73 | Things We Lost in the Fire | - | - | - | $473 | 97 | $414,156 | Jun 12 | Teodora Film | false |
| 74 | Made of Honor | - | - | - | $390 | 293 | $2,337,688 | Jun 12 | Sony Pictures Releasing | false |
| 75 | Shrooms | - | - | - | $368 | 111 | $1,143,622 | Aug 22 | Moviemax | false |
| 76 | The Incredible Hulk | - | - | - | $291 | 477 | $6,460,290 | Jun 18 | Universal Pictures International (UPI) | false |
| 77 | Il peso dell'aria | - | - | - | $262 | 5 | $57,119 | Jul 2 | Poker Film | false |
| 78 | Elling | - | - | - | $241 | 20 | $253,001 | Nov 22 | - | false |
| 79 | I Viceré | - | - | - | $225 | 187 | $2,584,556 | Nov 9 | 01 Distribution | false |
| 80 | King of California | - | - | - | $197 | 110 | $300,080 | May 16 | Moviemax | false |
| 81 | Deception | - | - | - | $193 | 208 | $664,207 | Aug 29 | Mikado Film | false |
| 82 | Woman's Hearts | - | - | - | $182 | 6 | $66,253 | Jun 13 | - | false |
| 83 | The Tree of Wooden Clogs | - | - | - | $154 | 1 | $7,790 | - | Istituto Luce | false |
