| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | El Regalo | - | - | - | $734,849 | 38 | $53,068 | 7.2% | 35 | Oct 2 | - | - | false |
| 2 | Mirrors | - | - | - | $563,687 | 26 | $83,802 | 14.9% | 25 | Oct 2 | - | 20th Century Fox International | false |
| 3 | Mamma Mia! | - | - | - | $417,860 | 37 | $92,675 | 22.2% | 37 | Oct 16 | - | United International Pictures | false |
| 4 | Space Chimps | - | - | - | $276,049 | 22 | $46,269 | 16.8% | 22 | Oct 2 | - | Bazuca Films | false |
| 5 | Tropic Thunder | - | - | - | $210,021 | 22 | $43,452 | 20.7% | 20 | Oct 9 | - | United International Pictures | false |
| 6 | The Nightmare Before Christmas 2009 3D Release | - | - | - | $206,466 | 3 | $33,403 | 16.2% | 3 | Oct 23 | - | Walt Disney Pictures | false |
| 7 | REC | - | - | - | $152,889 | 17 | $37,890 | 24.8% | 17 | Oct 30 | - | CDI Films | false |
| 8 | Nights in Rodanthe | - | - | - | $142,567 | 15 | $36,807 | 25.8% | 12 | Oct 2 | - | Warner Bros. | false |
| 9 | Before the Devil Knows You're Dead | - | - | - | $98,974 | 9 | $19,436 | 19.6% | 9 | Oct 9 | - | Bazuca Films | false |
| 10 | Blindness | - | - | - | $95,292 | 26 | $20,952 | 22% | 17 | Oct 23 | - | 20th Century Fox International | false |
| 11 | The Other Boleyn Girl | - | - | - | $94,904 | 14 | $31,736 | 33.4% | 12 | Oct 30 | - | Bazuca Films | false |
| 12 | Nim's Island | - | - | - | $77,987 | 12 | $26,387 | 33.8% | 12 | Oct 30 | - | United International Pictures | false |
| 13 | 88 Minutes | - | - | - | $71,011 | 17 | $16,124 | 22.7% | 11 | Oct 23 | - | Bazuca Films | false |
| 14 | Awake | - | - | - | $70,689 | 13 | $22,459 | 31.8% | 13 | Oct 16 | - | Bazuca Films | false |
| 15 | The Diving Bell and the Butterfly | - | - | - | $13,431 | 5 | $7,170 | 53.4% | 5 | Oct 30 | - | Transeuropa | false |
| 16 | Secrets | - | - | - | $12,929 | 9 | $4,331 | 33.5% | 9 | Oct 9 | - | Los Filmes de la Arcadia | false |
| 17 | Conversations with My Gardener | - | - | - | $11,811 | 4 | $6,950 | 58.8% | 4 | Oct 16 | - | Transeuropa | false |
| 18 | The Unknown Woman | - | - | - | $10,568 | 5 | $5,866 | 55.5% | 5 | Oct 2 | - | Impacto Cine | false |
| 19 | El cielo, la tierra, y la lluvia | - | - | - | $3,822 | 3 | $1,892 | 49.5% | 3 | Oct 16 | - | MC Film Dagitim | false |
| 20 | Alicia in the Land | - | - | - | $3,209 | 1 | - | - | - | Oct 31 | - | MC Film Dagitim | false |
| 21 | Vitus | - | - | - | $3,109 | 4 | $3,109 | 100% | 4 | Oct 30 | - | Los Filmes de la Arcadia | false |