| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Beverly Hills Chihuahua | - | - | - | $869,877 | 61 | $1,559,499 | Oct 9 | Walt Disney Pictures | false |
| 2 | Nights in Rodanthe | - | - | - | $739,458 | 49 | $879,399 | Oct 2 | Warner Bros. | false |
| 3 | Mirrors | - | - | - | $506,387 | 35 | $658,672 | Oct 2 | 20th Century Fox International | false |
| 4 | Journey to the Center of the Earth | - | - | - | $345,238 | 55 | $1,311,200 | Jul 17 | Distribution Company | false |
| 5 | Burn After Reading | - | - | - | $316,848 | 51 | $882,934 | Oct 23 | United International Pictures | false |
| 6 | You Don't Mess with the Zohan | - | - | - | $299,493 | 30 | $723,308 | Sep 18 | Sony Pictures Releasing | false |
| 7 | The Bank Job | - | - | - | $292,751 | 34 | $625,583 | Oct 16 | Alfa Films | false |
| 8 | Appaloosa | - | - | - | $236,484 | 30 | $339,178 | Oct 9 | Distribution Company | false |
| 9 | In Bruges | - | - | - | $231,206 | 19 | $273,533 | Oct 2 | Distribution Company | false |
| 10 | Taken | - | - | - | $215,284 | 30 | $572,787 | Sep 18 | 20th Century Fox International | false |
| 11 | Hellboy II: The Golden Army | - | - | - | $213,249 | 40 | $299,372 | Oct 9 | United International Pictures | false |
| 12 | A Boyfriend for My Wife | - | - | - | $183,965 | 91 | $5,655,910 | Aug 14 | Walt Disney Pictures | false |
| 13 | Tinker Bell | - | - | - | $164,396 | 58 | $788,678 | Sep 11 | Walt Disney Pictures | false |
| 14 | Tropic Thunder | - | - | - | $160,443 | 48 | $1,349,571 | Sep 4 | United International Pictures | false |
| 15 | Sex and the City | - | - | - | $120,400 | 72 | $1,694,714 | Jun 12 | Distribution Company | false |
| 16 | Mamma Mia! | - | - | - | $95,424 | 50 | $178,082 | Aug 21 | United International Pictures | false |
| 17 | The Forbidden Kingdom | - | - | - | $93,771 | 40 | $101,411 | Oct 2 | - | false |
| 18 | Dan in Real Life | - | - | - | $89,364 | 32 | $213,204 | Sep 25 | Distribution Company | false |
| 19 | My Brother is an Only Child | - | - | - | $83,589 | 13 | $222,886 | Sep 18 | Alfa Films | false |
| 20 | Lakeview Terrace | - | - | - | $78,846 | 30 | $103,566 | Oct 16 | Sony Pictures Releasing | false |
| 21 | Manual of Love 2008 Re-release | - | - | - | $67,584 | 9 | $136,530 | Sep 25 | Notro Films | false |
| 22 | Eagle Eye | - | - | - | $64,210 | 40 | $189,322 | Sep 25 | United International Pictures | false |
| 23 | Babylon A.D. | - | - | - | $62,100 | 30 | $261,450 | Sep 4 | 20th Century Fox International | false |
| 24 | The Strangers | - | - | - | $51,615 | 32 | $368,904 | Sep 11 | Distribution Company | false |
| 25 | REC | - | - | - | $50,599 | 20 | $225,119 | Sep 11 | CDI Films | false |
| 26 | The Camera Obscura 2008 Re-release | - | - | - | $44,218 | 10 | $64,009 | Oct 16 | Distribution Company | false |
| 27 | The Nest | - | - | - | $41,439 | 39 | $1,008,755 | Apr 24 | Distribution Company | false |
| 28 | Superhero Movie | - | - | - | $39,382 | 40 | $334,873 | Sep 11 | Pachamama Cine | false |
| 29 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $29,419 | 2 | $157,244 | Sep 4 | Walt Disney Pictures | false |
| 30 | Wanted | - | - | - | $27,067 | 46 | $583,615 | Aug 28 | United International Pictures | false |
| 31 | Fast Food Nation | - | - | - | $24,706 | 14 | $41,608 | Oct 23 | Impacto Cine | false |
| 32 | La próxima estación | - | - | - | $21,260 | 13 | $120,249 | Sep 4 | Primer Plano Film Group | false |
| 33 | The Paranoids | - | - | - | $20,338 | 20 | $38,597 | Oct 23 | Primer Plano Film Group | false |
| 34 | Reasons for Not Falling in Love | - | - | - | $16,429 | 44 | $542,931 | Sep 4 | Distribution Company | false |
| 35 | The Magic Flute | - | - | - | $16,219 | 10 | $27,214 | Oct 23 | Distribution Company | false |
| 36 | Irina Palm | - | - | - | $14,577 | 11 | $43,250 | Sep 25 | Alfa Films | false |
| 37 | Harold & Kumar Escape from Guantanamo Bay | - | - | - | $14,372 | 10 | $25,806 | Oct 23 | Distribution Company | false |
| 38 | Days of Darkness | - | - | - | $12,870 | 4 | $15,773 | Oct 16 | Alfa Films | false |
| 39 | Still Life | - | - | - | $12,340 | 3 | $16,368 | Oct 16 | 791 Cine | false |
| 40 | Francesca | - | - | - | $9,401 | 6 | $181,839 | Jul 17 | IFA | false |
| 41 | Lo que sé de Lola | - | - | - | $6,291 | 3 | $6,291 | Oct 2 | 791 Cine | false |
| 42 | El cine de Maite | - | - | - | $4,621 | 5 | $4,155 | Oct 16 | Primer Plano Film Group | false |
| 43 | Run Fatboy Run | - | - | - | $4,047 | 19 | $80,421 | Aug 28 | Distribution Company | false |
| 44 | Black Sheep | - | - | - | $3,757 | 31 | $148,517 | Aug 21 | Pachamama Cine | false |
| 45 | WALL·E | - | - | - | $3,563 | 167 | $4,664,019 | Jul 10 | Walt Disney Pictures | false |
| 46 | U2 3D | - | - | - | $3,551 | 1 | $140,453 | Mar 27 | IMAX | false |
| 47 | Impunidad | - | - | - | $3,539 | 4 | $3,539 | Oct 2 | Primer Plano Film Group | false |
| 48 | The Princess of Nebraska | - | - | - | $2,653 | 3 | $3,456 | Oct 9 | Primer Plano Film Group | false |
| 49 | The Diving Bell and the Butterfly | - | - | - | $2,532 | 10 | $105,015 | Aug 14 | Alfa Films | false |
| 50 | Star Wars: The Clone Wars | - | - | - | $2,242 | 43 | $236,497 | Aug 14 | Warner Bros. | false |
| 51 | Aaltra | - | - | - | $2,189 | 2 | $6,083 | Sep 25 | Vera Films | false |
| 52 | 100% lucha, la película | - | - | - | $2,059 | 53 | $874,285 | Jul 10 | Primer Plano Film Group | false |
| 53 | Death at a Funeral | - | - | - | $1,583 | 33 | $2,153,078 | Mar 6 | Compañía General de la Imagen (CGI) | false |
| 54 | The Other Boleyn Girl | - | - | - | $1,555 | 26 | $339,213 | Aug 7 | Distribution Company | false |
| 55 | A Girl Cut in Two | - | - | - | $1,544 | 20 | $286,698 | Jul 24 | Alfa Films | false |
| 56 | Cassandra's Dream | - | - | - | $1,529 | 30 | $583,973 | Jun 5 | Alfa Films | false |
| 57 | The X Files: I Want to Believe | - | - | - | $1,401 | 45 | $706,287 | Aug 14 | 20th Century Fox International | false |
| 58 | The Dark Knight | - | - | - | $1,323 | 160 | $5,480,477 | Jul 17 | Warner Bros. | false |
| 59 | Abrígate | - | - | - | $1,179 | 3 | $3,124 | Sep 11 | Walt Disney Pictures | false |
| 60 | Los invisibles | - | - | - | $1,149 | 1 | $1,149 | Oct 2 | Primer Plano Film Group | false |
| 61 | The Orphanage | - | - | - | $1,086 | 35 | $752,899 | Mar 13 | CDI Films | false |
| 62 | Los superagentes, nueva generación | - | - | - | $1,000 | 75 | $864,512 | Jul 17 | Argentina Sono Film S.A.C.I. | false |
| 63 | Café de los maestros | - | - | - | $889 | 8 | $94,126 | Jun 26 | Alfa Films | false |
| 64 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $769 | 127 | $2,893,362 | Jul 31 | United International Pictures | false |
| 65 | High School Musical: El Desafío | - | - | - | $744 | 141 | $1,766,913 | Jul 17 | Walt Disney Pictures | false |
| 66 | Conversations with My Gardener | - | - | - | $691 | 14 | $221,688 | Apr 24 | Alfa Films | false |
| 67 | Get Smart | - | - | - | $597 | 107 | $2,252,024 | Jun 26 | Warner Bros. | false |
| 68 | Four Minutes | - | - | - | $525 | 14 | $159,960 | Aug 28 | Alfa Films | false |
| 69 | The Chronicles of Narnia: Prince Caspian | - | - | - | $376 | 189 | $3,702,166 | Jun 12 | Walt Disney Pictures | false |
| 70 | The Game Plan | - | - | - | $362 | 58 | $1,519,256 | Feb 14 | Walt Disney Pictures | false |
| 71 | The Oxford Murders | - | - | - | $361 | 23 | $589,788 | May 8 | Pachamama Cine | false |
| 72 | Lars and the Real Girl | - | - | - | $353 | 18 | $74,502 | Aug 21 | Impacto Cine | false |
| 73 | An American Haunting | - | - | - | $334 | 39 | $529,788 | Jan 31 | Distribution Company | false |
| 74 | Golden Door | - | - | - | $322 | 3 | $111,029 | Sep 18 | Primer Plano Film Group | false |
| 75 | Enchanted | - | - | - | $261 | 108 | $2,862,455 | Jan 3 | Walt Disney Pictures | false |
| 76 | You, the Living | - | - | - | $260 | 7 | $20,807 | Sep 4 | Zeta Films | false |
| 77 | Leonera | - | - | - | $243 | 30 | $486,380 | May 29 | Walt Disney Pictures | false |
| 78 | Awake | - | - | - | $210 | 31 | $274,878 | May 15 | Distribution Company | false |
| 79 | Lamb of God | - | - | - | $196 | 13 | $144,627 | May 8 | Alfa Films | false |
| 80 | Bratz | - | - | - | $128 | 27 | $44,700 | Feb 14 | Pachamama Cine | false |
| 81 | Shine a Light | - | - | - | $54 | 33 | $99,576 | Apr 10 | Distribution Company | false |
| 82 | Pellet | - | - | - | $47 | 1 | $30,903 | Nov 22 | Primer Plano Film Group | false |
| 83 | Argentina latente | - | - | - | $34 | 3 | $31,599 | May 24 | Primer Plano Film Group | false |
| 84 | Amélie | - | - | - | $17 | 2 | $587,337 | Jan 24 | Buena Vista International | false |
| 85 | Pulqui, un instante en la patria de la felicidad | - | - | - | $5 | 1 | $1,717 | Jul 12 | Primer Plano Film Group | false |
