| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Devil Wears Prada | - | - | - | $11,552,846 | 420 | $19,304,728 | Oct 13 | 20th Century Fox International | false |
| 2 | World Trade Center | - | - | - | $5,500,090 | 333 | $7,093,226 | Oct 13 | United International Pictures | false |
| 3 | Scoop | - | - | - | $4,834,710 | 352 | $5,595,044 | Oct 6 | Medusa Distribuzione | false |
| 4 | Miami Vice | - | - | - | $4,161,476 | 298 | $4,372,997 | Oct 6 | United International Pictures | false |
| 5 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $3,090,665 | 877 | $25,212,003 | Sep 13 | Buena Vista International | false |
| 6 | Click | - | - | - | $2,134,739 | 194 | $3,187,895 | Sep 29 | Sony Pictures Releasing | false |
| 7 | Over the Hedge | - | - | - | $2,078,012 | 452 | $9,691,689 | Oct 27 | United International Pictures | false |
| 8 | The Departed | - | - | - | $2,062,024 | 422 | $12,237,244 | Oct 27 | Medusa Distribuzione | false |
| 9 | The Unknown Woman | - | - | - | $2,052,379 | 297 | $5,459,456 | Oct 20 | Medusa Distribuzione | false |
| 10 | The Black Dahlia | - | - | - | $1,742,593 | 318 | $2,822,578 | Sep 29 | 01 Distribution | false |
| 11 | The Break-Up | - | - | - | $1,697,638 | 297 | $5,530,907 | Sep 22 | United International Pictures | false |
| 12 | Golden Door | - | - | - | $1,598,599 | 122 | $3,257,977 | Sep 22 | 01 Distribution | false |
| 13 | Perfume: The Story of a Murderer | - | - | - | $1,303,657 | 335 | $3,639,053 | Sep 22 | Medusa Distribuzione | false |
| 14 | N (Io e Napoleone) | - | - | - | $1,107,978 | 207 | $1,253,693 | Oct 13 | Medusa Distribuzione | false |
| 15 | Monster House | - | - | - | $861,977 | 195 | $1,012,851 | Oct 13 | Sony Pictures Releasing | false |
| 16 | Little Miss Sunshine | - | - | - | $677,657 | 68 | $2,039,673 | Sep 22 | 20th Century Fox International | false |
| 17 | The Hoax | - | - | - | $634,345 | 293 | $634,345 | Oct 20 | Eagle Pictures | false |
| 18 | Lady in the Water | - | - | - | $594,705 | 174 | $1,067,315 | Sep 29 | Warner Bros. | false |
| 19 | Babel | - | - | - | $589,411 | 270 | $3,372,629 | Oct 27 | 01 Distribution | false |
| 20 | Cars | - | - | - | $558,830 | 637 | $16,456,342 | Aug 23 | Buena Vista International | false |
| 21 | Fur: An Imaginary Portrait of Diane Arbus | - | - | - | $516,277 | 195 | $516,277 | Oct 20 | Nexo | false |
| 22 | Baciami piccina | - | - | - | $361,433 | 170 | $632,826 | Sep 29 | Medusa Distribuzione | false |
| 23 | The Queen | - | - | - | $276,726 | 191 | $2,682,560 | Sep 15 | BIM Distribuzione | false |
| 24 | Water 2006 Re-release | - | - | - | $216,571 | 18 | $219,127 | Oct 6 | Warner Bros. | false |
| 25 | Fascisti su Marte | - | - | - | $180,889 | 68 | $1,059,366 | Oct 27 | Fandango | false |
| 26 | Those Happy Days | - | - | - | $179,682 | 124 | $439,050 | Oct 27 | Filmauro | false |
| 27 | Comedy of Power | - | - | - | $124,217 | 44 | $129,200 | Oct 6 | BIM Distribuzione | false |
| 28 | Clerks II | - | - | - | $97,684 | 115 | $215,369 | Sep 29 | Mikado Film | false |
| 29 | The Missing Star | - | - | - | $75,043 | 267 | $2,723,863 | Sep 8 | 01 Distribution | false |
| 30 | A Scanner Darkly | - | - | - | $69,418 | 43 | $69,418 | Oct 20 | Warner Bros. | false |
| 31 | The Ant Bully | - | - | - | $61,429 | 147 | $349,807 | Sep 22 | Warner Bros. | false |
| 32 | Thank You for Smoking | - | - | - | $53,224 | 168 | $1,719,187 | Sep 1 | Lucky Red | false |
| 33 | The Stone Merchant | - | - | - | $45,031 | 215 | $1,029,807 | Sep 15 | Medusa Distribuzione | false |
| 34 | Down in the Valley | - | - | - | $43,793 | 116 | $43,793 | Oct 20 | Buena Vista International | false |
| 35 | Gardens in Autumn | - | - | - | $34,880 | 14 | $274,758 | Oct 27 | Mikado Film | false |
| 36 | Grbavica | - | - | - | $31,233 | 26 | $31,233 | Oct 27 | Istituto Luce | false |
| 37 | 12:08 East of Bucharest | - | - | - | $29,085 | 12 | $63,712 | Oct 6 | Istituto Luce | false |
