| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Open Season | - | - | - | $351,744 | 52 | $605,159 | Oct 5 | Sony Pictures Releasing | false |
| 2 | The Devil Wears Prada | - | - | - | $349,481 | 36 | $951,335 | Sep 21 | 20th Century Fox International | false |
| 3 | The Guardian | - | - | - | $341,886 | 47 | $480,461 | Oct 5 | Buena Vista International | false |
| 4 | The Illusionist | - | - | - | $310,451 | 29 | $1,291,249 | Oct 19 | Alfa Films | false |
| 5 | You, Me and Dupree | - | - | - | $266,436 | 30 | $553,132 | Sep 28 | United International Pictures | false |
| 6 | World Trade Center | - | - | - | $180,383 | 40 | $378,092 | Oct 19 | United International Pictures | false |
| 7 | The Lake House | - | - | - | $178,040 | 28 | $720,346 | Aug 31 | Warner Bros. | false |
| 8 | Pulse | - | - | - | $177,243 | 25 | $297,943 | Oct 12 | Distribution Company | false |
| 9 | Barnyard | - | - | - | $159,164 | 32 | $363,704 | Oct 12 | United International Pictures | false |
| 10 | Cheese Head | - | - | - | $116,664 | 20 | $135,048 | Oct 12 | Primer Plano Film Group | false |
| 11 | Volver | - | - | - | $107,905 | 31 | $956,119 | Aug 10 | 20th Century Fox International | false |
| 12 | The Valet | - | - | - | $103,718 | 25 | $124,485 | Oct 5 | Alfa Films | false |
| 13 | Click | - | - | - | $103,027 | 31 | $710,028 | Aug 17 | Sony Pictures Releasing | false |
| 14 | Little Miss Sunshine | - | - | - | $102,052 | 14 | $190,473 | Oct 12 | 20th Century Fox International | false |
| 15 | The Wind that Shakes the Barley | - | - | - | $92,853 | 12 | $118,625 | Oct 5 | Distribution Company | false |
| 16 | Lady in the Water | - | - | - | $61,207 | 25 | $399,003 | Aug 24 | Warner Bros. | false |
| 17 | Miami Vice | - | - | - | $54,502 | 50 | $465,908 | Sep 7 | United International Pictures | false |
| 18 | Friends with Money | - | - | - | $54,501 | 13 | $110,704 | Oct 12 | Sony Pictures Releasing | false |
| 19 | The Covenant | - | - | - | $53,900 | 29 | $194,038 | Oct 26 | Sony Pictures Releasing | false |
| 20 | Snakes on a Plane | - | - | - | $52,211 | 49 | $272,200 | Sep 14 | Distribution Company | false |
| 21 | United 93 | - | - | - | $51,869 | 20 | $321,365 | Aug 31 | United International Pictures | false |
| 22 | Yo Presidente | - | - | - | $46,467 | 13 | $46,467 | Oct 19 | Distribution Company | false |
| 23 | Heading South | - | - | - | $43,228 | 13 | $130,487 | Oct 26 | Pachamama Cine | false |
| 24 | The Jacket | - | - | - | $28,181 | 28 | $205,285 | Sep 7 | Alfa Films | false |
| 25 | Thank You for Smoking | - | - | - | $26,938 | 14 | $86,121 | Oct 26 | 20th Century Fox International | false |
| 26 | Born and Bred | - | - | - | $25,124 | 13 | $43,375 | Oct 26 | Distribution Company | false |
| 27 | The Tiger and the Snow | - | - | - | $21,937 | 19 | $93,280 | Sep 28 | Distribution Company | false |
| 28 | Transamerica | - | - | - | $17,455 | 19 | $153,455 | Sep 14 | Alfa Films | false |
| 29 | Swindled 2006 Re-release | - | - | - | $16,936 | 15 | $16,936 | Oct 12 | Eurocine | false |
| 30 | Fuerza aérea sociedad anónima | - | - | - | $15,730 | 19 | $297,366 | Aug 31 | Distribution Company | false |
| 31 | The Road to Guantanamo | - | - | - | $14,917 | 12 | $35,087 | Oct 26 | Alfa Films | false |
| 32 | A Perfect Couple | - | - | - | $10,591 | 3 | $10,591 | Oct 19 | 791 Cine | false |
| 33 | Monster House | - | - | - | $10,545 | 48 | $555,676 | Aug 10 | Sony Pictures Releasing | false |
| 34 | The Break-Up | - | - | - | $9,529 | 40 | $960,763 | Aug 3 | United International Pictures | false |
| 35 | The Sentinel | - | - | - | $7,668 | 41 | $567,876 | Aug 17 | 20th Century Fox International | false |
