| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Eternals | - | - | - | $7,657,208 | 343 | $8,594,295 | Nov 5 | Walt Disney Studios Motion Pictures | false |
| 2 | The Vault | - | - | - | $4,022,084 | 376 | $6,662,713 | Nov 26 | Sony Pictures Releasing | false |
| 3 | Encanto | - | - | - | $1,636,441 | 361 | $8,176,302 | Nov 26 | Walt Disney Studios Motion Pictures | false |
| 4 | The Last Duel | - | - | - | $1,376,529 | 300 | $2,123,551 | Oct 29 | 20th Century Studios | false |
| 5 | Venom: Let There Be Carnage | - | - | - | $1,272,185 | 670 | $10,400,000 | Oct 15 | Sony Pictures Releasing | false |
| 6 | Ron's Gone Wrong | - | - | - | $968,867 | 435 | $1,820,396 | Oct 22 | Walt Disney Studios Motion Pictures | false |
| 7 | The Wolf and the Lion | - | - | - | $888,976 | 266 | $920,715 | Nov 5 | Miramax | false |
| 8 | The Addams Family 2 | - | - | - | $874,987 | 337 | $5,122,557 | Oct 8 | Universal Pictures | false |
| 9 | The Good Boss | - | - | - | $860,069 | 309 | $4,331,817 | Oct 15 | Miramax | false |
| 10 | House of Gucci | - | - | - | $856,790 | 340 | $4,165,789 | Nov 26 | Universal Pictures International (UPI) | false |
| 11 | Harry Potter and the Sorcerer's Stone 2021 Re-release | - | - | - | $582,125 | 266 | $582,125 | Oct 22 | Warner Bros. | false |
| 12 | Lemon and Poppy Seed Cake | - | - | - | $476,518 | 107 | $671,706 | Nov 12 | Filmax | false |
| 13 | My Hero Academia: World Heroes' Mission | - | - | - | $460,584 | 164 | $461,131 | Nov 12 | Selecta Visión | false |
| 14 | The French Dispatch | - | - | - | $451,595 | 205 | $1,118,511 | Oct 22 | Walt Disney Studios Motion Pictures | false |
| 15 | No Time to Die | - | - | - | $427,631 | 382 | $9,048,176 | Oct 1 | Universal Pictures International (UPI) | false |
| 16 | Resident Evil: Welcome to Raccoon City | - | - | - | $418,044 | 314 | $1,015,870 | Nov 26 | Sony Pictures Releasing | false |
| 17 | Parallel Mothers | - | - | - | $410,607 | 391 | $2,991,523 | Oct 8 | Sony Pictures Releasing | false |
| 18 | Antlers | - | - | - | $363,197 | 114 | $484,630 | Nov 19 | Walt Disney Studios Motion Pictures | false |
| 19 | The Courier | - | - | - | $345,087 | 211 | $586,970 | Oct 29 | Diamond Films | false |
| 20 | Halloween Kills | - | - | - | $333,262 | 357 | $2,056,398 | Oct 22 | Universal Pictures International (UPI) | false |
| 21 | Spencer | - | - | - | $324,298 | 258 | $414,387 | Nov 19 | Diamond Films | false |
| 22 | Cuidado con lo que deseas | - | - | - | $238,776 | 210 | $249,836 | Nov 12 | A Contracorriente Films | false |
| 23 | Maixabel | - | - | - | $215,282 | 364 | $3,176,720 | Sep 24 | Walt Disney Pictures | false |
| 24 | Eiffel | - | - | - | $112,416 | 159 | $112,416 | Nov 12 | Entertainment One | false |
| 25 | El refugio | - | - | - | $104,986 | 185 | $197,332 | Nov 26 | Filmax | false |
| 26 | Dune: Part One | - | - | - | $101,034 | 746 | $9,037,705 | Sep 17 | Warner Bros. | false |
| 27 | The Daughter | - | - | - | $87,994 | 112 | $249,282 | Nov 26 | Caramel Films | false |
| 28 | Last Night in Soho | - | - | - | $83,688 | 300 | $487,767 | Nov 19 | Universal Pictures International (UPI) | false |
| 29 | The Many Saints of Newark | - | - | - | $77,063 | 161 | $77,063 | Nov 5 | Warner Bros. | false |
| 30 | Till Death | - | - | - | $68,130 | 214 | $68,130 | Nov 12 | Vértice 360 | false |
| 31 | España, la primera globalización | - | - | - | $63,867 | 61 | $298,603 | Oct 15 | - | false |
| 32 | The Replacement | - | - | - | $42,927 | 67 | $136,866 | Oct 29 | Karma Films | false |
| 33 | Monster Family 2 | - | - | - | $30,805 | 155 | $203,066 | Oct 29 | Big Picture Films | false |
| 34 | Wheel of Fortune and Fantasy | - | - | - | $27,018 | 30 | $27,122 | Nov 5 | Caramel Films | false |
| 35 | Once Upon a Time in Euskadi | - | - | - | $26,894 | 43 | $90,364 | Oct 29 | Entertainment One | false |
| 36 | Petite Maman | - | - | - | $22,605 | 41 | $92,535 | Oct 29 | Elastica | false |
| 37 | Sooryavanshi | - | - | - | $21,653 | 19 | $21,653 | Nov 5 | - | false |
| 38 | Josefina | - | - | - | $20,915 | 250 | $29,673 | Nov 5 | Super 8 | false |
| 39 | Blithe Spirit | - | - | - | $20,732 | 46 | $20,860 | Nov 5 | A Contracorriente Films | false |
| 40 | Out of Sync | - | - | - | $20,007 | 514 | $23,629 | Nov 5 | Filmax | false |
| 41 | Lamb | - | - | - | $18,196 | 70 | $18,196 | Nov 26 | Vértigo Films | false |
| 42 | Don't Breathe 2 | - | - | - | $16,274 | 315 | $2,071,084 | Sep 24 | Sony Pictures Releasing | false |
| 43 | El sueño de Sigena | - | - | - | $12,731 | 6 | $24,315 | Nov 12 | Alfa Films | false |
| 44 | Terremoto | - | - | - | $12,431 | 248 | $534,013 | Oct 1 | Begin Again Films | false |
| 45 | The Belly of the Sea | - | - | - | $12,272 | 330 | $14,657 | Nov 12 | Elastica | false |
| 46 | Medjugorje, la película | - | - | - | $12,182 | 56 | $347,693 | Oct 1 | European Dreams Factory | false |
| 47 | Libertad | - | - | - | $8,294 | 35 | $96,623 | Nov 19 | Avalon | false |
| 48 | The Sacred Spirit | - | - | - | $7,473 | 16 | $32,718 | Nov 26 | - | false |
| 49 | Who's Stopping Us | - | - | - | $4,724 | 235 | $19,597 | Oct 29 | Atalanta Filmes | false |
| 50 | Panteras: Viviendo entre felinos | - | - | - | $4,101 | 4 | $16,463 | Nov 5 | Wanda Visión S.A. | false |
| 51 | Maria Solinha | - | - | - | $3,361 | 12 | $9,231 | Nov 26 | - | false |
| 52 | Free Guy | - | - | - | $1,617 | 325 | $3,607,833 | Aug 18 | Walt Disney Pictures | false |
| 53 | A este lado del mundo | - | - | - | $1,390 | 2 | $4,828 | - | - | false |
| 54 | Zutik | - | - | - | $1,265 | 14 | $6,296 | Oct 22 | Filmax | false |
| 55 | Sediments | - | - | - | $1,194 | 6 | $1,776 | Nov 12 | Begin Again Films | false |
| 56 | The King of all the World | - | - | - | $1,192 | 8 | $1,192 | Nov 12 | Syldavia Cinema | false |
| 57 | The Phantom of the Sauna | - | - | - | $990 | 5 | $11,279 | Nov 19 | - | false |
| 58 | Jungle Cruise | - | - | - | $852 | 398 | $4,078,906 | Jul 30 | Walt Disney Studios Motion Pictures | false |
| 59 | Apaiz Kartzela | - | - | - | $758 | 3 | $5,773 | Nov 26 | Syldavia Cinema | false |
| 60 | Algo salvaje. La historia de Bambino | - | - | - | $753 | 3 | $6,430 | Nov 19 | Phoenix Productions (II) | false |
| 61 | Finlandia | - | - | - | $721 | 4 | $7,994 | Jun 10 | - | false |
| 62 | The Laws of the Border | - | - | - | $708 | 338 | $779,919 | Oct 8 | Warner Bros. | false |
| 63 | Bolante baten historia | - | - | - | $609 | 2 | $5,686 | Nov 19 | Barton Films | false |
| 64 | Tierra Santa. El último peregrino | - | - | - | $556 | 27 | $23,235 | May 21 | European Dreams Factory | false |
| 65 | Magaluf Ghost Town | - | - | - | $531 | 5 | $1,512 | Nov 26 | Begin Again Films | false |
| 66 | Nur eta herensugearen tenplua 2021 Re-release | - | - | - | $523 | 7 | $6,427 | - | Barton Films | false |
| 67 | Wojtyla. La investigación | - | - | - | $468 | 1 | $4,369 | - | European Dreams Factory | false |
| 68 | Love of Lesbian: El gran truco final | - | - | - | $417 | 10 | $2,965 | Nov 26 | - | false |
| 69 | Last Days of Spring | - | - | - | $355 | 1 | $4,412 | Apr 2 | - | false |
| 70 | The Return: Life After ISIS | - | - | - | $322 | 1 | $2,933 | May 28 | - | false |
| 71 | Buñuel: A Surrealist Filmmaker | - | - | - | $258 | 3 | $258 | Nov 5 | Sherlock Films | false |
| 72 | Lobster Soup | - | - | - | $247 | 1 | $1,585 | - | - | false |
| 73 | Ez, eskerrik asko! Gladysen leihoa | - | - | - | $147 | 1 | $584 | Mar 26 | - | false |
| 74 | Sevillanas de Brooklyn | - | - | - | $130 | 100 | $126,635 | Sep 17 | Filmax | false |
| 75 | Descarrilados | - | - | - | $84 | 350 | $1,147,367 | Aug 20 | Sony Pictures Releasing | false |
| 76 | Vivo | - | - | - | $72 | 8 | $253,735 | Jun 17 | Bosco Films | false |
| 77 | More the Merrier | - | - | - | $40 | 158 | $247,061 | Jul 30 | Filmax | false |
| 78 | Balandrau. Frozen Hell | - | - | - | $40 | 1 | $103 | May 14 | - | false |
| 79 | La revolución bailando | - | - | - | $32 | 2 | $459 | Nov 12 | Begin Again Films | false |
| 80 | Aztarnak - Huellas | - | - | - | $29 | 2 | $3,161 | Oct 15 | Barton Films | false |
| 81 | Impuros | - | - | - | $13 | 1 | $650 | Oct 29 | Sherlock Films | false |
