| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $1,700,775 | 72 | $2,359,543 | Nov 18 | Warner Bros. | false |
| 2 | Paranormal Activity 2 | - | - | - | $884,747 | 40 | $967,470 | Nov 4 | Paramount Pictures International | false |
| 3 | Life as We Know It | - | - | - | $322,405 | 26 | $540,281 | Oct 28 | Warner Bros. | false |
| 4 | Hachi: A Dog's Tale | - | - | - | $322,173 | 34 | $362,576 | Nov 11 | - | false |
| 5 | Megamind | - | - | - | $305,328 | 78 | $1,253,184 | Dec 2 | Paramount Pictures International | false |
| 6 | Piranha 3D | - | - | - | $289,906 | 23 | $494,194 | Oct 28 | - | false |
| 7 | Avatar 2010 Special Edition | - | - | - | $232,473 | 7 | $247,717 | Nov 4 | 20th Century Fox International | false |
| 8 | Due Date | - | - | - | $223,737 | 23 | $247,240 | Nov 4 | Warner Bros. | false |
| 9 | Devil | - | - | - | $163,013 | 40 | $478,951 | Nov 25 | Universal Pictures International (UPI) | false |
| 10 | The Grudge 3 | - | - | - | $136,978 | 18 | $182,970 | Nov 11 | - | false |
| 11 | Furry Vengeance | - | - | - | $133,718 | 27 | $470,819 | Oct 14 | Venus | false |
| 12 | Eat Pray Love | - | - | - | $120,594 | 17 | $346,983 | Oct 21 | Sony Pictures Releasing | false |
| 13 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $114,651 | 63 | $1,330,099 | Oct 7 | Warner Bros. | false |
| 14 | Solomon Kane | - | - | - | $92,850 | 25 | $172,832 | Oct 28 | Venus | false |
| 15 | Jackass 3D | - | - | - | $86,943 | 10 | $86,943 | Nov 11 | Paramount Pictures International | false |
| 16 | The Town | - | - | - | $85,182 | 25 | $243,273 | Oct 21 | Warner Bros. | false |
| 17 | Machete | - | - | - | $73,431 | 19 | $80,535 | Nov 11 | Sony Pictures Releasing | false |
| 18 | The Last Exorcism | - | - | - | $68,068 | 32 | $497,696 | Oct 14 | - | false |
| 19 | Ex | - | - | - | $60,258 | 8 | $116,428 | Nov 18 | - | false |
| 20 | Brooklyn's Finest 2010 Re-release | - | - | - | $48,470 | 15 | $50,058 | Nov 4 | - | false |
| 21 | Nanny McPhee Returns | - | - | - | $43,069 | 34 | $591,121 | Sep 30 | Universal Pictures International (UPI) | false |
| 22 | Myths and Legends: The New Alliance | - | - | - | $36,931 | 22 | $106,569 | Nov 11 | - | false |
| 23 | The Other Man | - | - | - | $36,388 | 12 | $61,007 | Oct 28 | - | false |
| 24 | Tinker Bell and the Great Fairy Rescue | - | - | - | $21,480 | 25 | $309,056 | Sep 16 | Walt Disney Pictures | false |
| 25 | The Other Guys | - | - | - | $18,108 | 30 | $207,262 | Sep 23 | Sony Pictures Releasing | false |
| 26 | Mongol: The Rise of Genghis Khan | - | - | - | $17,972 | 12 | $120,914 | Oct 14 | - | false |
| 27 | Killers | - | - | - | $17,807 | 30 | $254,090 | Oct 7 | - | false |
| 28 | La Vigilia | - | - | - | $13,559 | 13 | $29,562 | Oct 28 | Andes Films | false |
| 29 | Law Abiding Citizen | - | - | - | $11,683 | 12 | $88,346 | Oct 14 | - | false |
| 30 | Pandorum | - | - | - | $10,804 | 8 | $31,258 | Oct 28 | - | false |
| 31 | The Haunting of Molly Hartley | - | - | - | $10,474 | 20 | $152,014 | Aug 19 | - | false |
| 32 | Going the Distance | - | - | - | $9,673 | 26 | $327,280 | Sep 16 | Warner Bros. | false |
| 33 | Killshot | - | - | - | $9,557 | 12 | $69,634 | Oct 7 | - | false |
| 34 | Possession | - | - | - | $8,830 | 16 | $87,871 | Sep 30 | - | false |
| 35 | Labor Pains | - | - | - | $7,867 | 17 | $129,778 | Sep 9 | - | false |
| 36 | Art of the Devil 3 2010 Re-release | - | - | - | $7,492 | 10 | $68,491 | Sep 23 | - | false |
| 37 | Despicable Me | - | - | - | $6,389 | 62 | $2,092,292 | Jul 28 | Universal Pictures International (UPI) | false |
| 38 | The Young Victoria | - | - | - | $5,608 | 8 | $59,905 | Sep 30 | - | false |
| 39 | Shrek Forever After | - | - | - | $5,062 | 77 | $4,111,292 | Jul 8 | Paramount Pictures International | false |
| 40 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $4,198 | 16 | $122,730 | Sep 2 | - | false |
| 41 | Takers 2010 Re-release | - | - | - | $4,080 | 25 | $79,560 | Oct 14 | Sony Pictures Releasing | false |
| 42 | The Road | - | - | - | $3,604 | 12 | $40,356 | Oct 21 | - | false |
| 43 | The Last Airbender | - | - | - | $2,709 | 75 | $2,120,847 | Aug 26 | Paramount Pictures International | false |
| 44 | A Single Man | - | - | - | $2,345 | 6 | $18,259 | Oct 21 | - | false |
| 45 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $2,320 | 66 | $1,304,761 | Aug 12 | Warner Bros. | false |
| 46 | Garfield's Pet Force | - | - | - | $1,033 | 16 | $644,106 | May 13 | - | false |
| 47 | Salt | - | - | - | $626 | 42 | $377,221 | Sep 30 | Sony Pictures Releasing | false |
| 48 | Oceans | - | - | - | $567 | 13 | $81,657 | Sep 23 | - | false |
| 49 | Wall Street: Money Never Sleeps | - | - | - | $537 | 25 | $355,638 | Sep 23 | 20th Century Fox International | false |
| 50 | October | - | - | - | $390 | 10 | $52,270 | Oct 7 | United International Pictures | false |
| 51 | Undertow | - | - | - | $144 | 22 | $169,074 | Aug 26 | - | false |
| 52 | Friend Zone 2010 Re-release | - | - | - | $98 | 10 | $44,061 | Sep 9 | - | false |
| 53 | Resident Evil: Afterlife | - | - | - | $92 | 67 | $1,262,371 | Sep 16 | Sony Pictures Releasing | false |
| 54 | Two Lovers | - | - | - | $15 | 10 | $78,914 | May 20 | - | false |
