| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $13,743,418 | 1,069 | $22,857,707 | Nov 18 | Warner Bros. | false |
| 2 | Due Date | - | - | - | $4,292,633 | 522 | $4,592,401 | Nov 5 | Warner Bros. | false |
| 3 | Paranormal Activity 2 | - | - | - | $3,708,042 | 452 | $8,185,616 | Oct 22 | Paramount Pictures International | false |
| 4 | A Turtle's Tale: Sammy's Adventures | - | - | - | $3,157,286 | 664 | $4,909,783 | Oct 29 | - | false |
| 5 | Tangled | - | - | - | $2,961,991 | 932 | $14,131,811 | Nov 26 | Walt Disney Pictures | false |
| 6 | RED | - | - | - | $1,871,635 | 350 | $2,050,154 | Nov 5 | - | false |
| 7 | Life as We Know It | - | - | - | $1,366,427 | 341 | $4,067,433 | Oct 15 | Warner Bros. | false |
| 8 | Te presento a Laura | - | - | - | $1,244,303 | 183 | $2,206,942 | Oct 29 | Videocine | false |
| 9 | Biutiful | - | - | - | $1,167,987 | 259 | $2,789,488 | Oct 22 | Videocine | false |
| 10 | The Town | - | - | - | $1,082,544 | 250 | $1,867,154 | Oct 29 | Warner Bros. | false |
| 11 | Saw 3D | - | - | - | $1,007,481 | 150 | $1,342,094 | Oct 29 | Walt Disney Pictures | false |
| 12 | The Last Exorcism | - | - | - | $876,499 | 292 | $3,031,584 | Oct 15 | Gussi Films | false |
| 13 | Open Season 3 | - | - | - | $818,071 | 250 | $1,160,078 | Oct 29 | Sony Pictures Releasing | false |
| 14 | Eat Pray Love | - | - | - | $780,359 | 150 | $2,856,933 | Sep 24 | Sony Pictures Releasing | false |
| 15 | Buried | - | - | - | $657,213 | 197 | $1,326,271 | Nov 12 | - | false |
| 16 | Machete | - | - | - | $601,023 | 200 | $945,321 | Nov 12 | Sony Pictures Releasing | false |
| 17 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $598,491 | 757 | $6,685,593 | Oct 8 | Warner Bros. | false |
| 18 | Sin ella | - | - | - | $591,414 | 299 | $724,808 | Nov 5 | Walt Disney Pictures | false |
| 19 | Jackass 3D | - | - | - | $560,580 | 180 | $622,524 | Nov 12 | Paramount Pictures International | false |
| 20 | Devil | - | - | - | $548,207 | 347 | $2,193,500 | Nov 26 | Universal Pictures International (UPI) | false |
| 21 | Back to the Future Part II 2010 Re-release | - | - | - | $543,232 | 90 | $543,232 | Nov 5 | Universal Pictures International (UPI) | false |
| 22 | Skyline | - | - | - | $449,178 | 230 | $1,909,935 | Nov 26 | Gussi Films | false |
| 23 | Hell | - | - | - | $388,580 | 336 | $6,703,873 | Sep 3 | - | false |
| 24 | Charlie St. Cloud | - | - | - | $344,955 | 180 | $1,398,859 | Oct 1 | Universal Pictures International (UPI) | false |
| 25 | Dinner for Schmucks | - | - | - | $339,626 | 163 | $800,973 | Oct 15 | Paramount Pictures International | false |
| 26 | Wall Street: Money Never Sleeps | - | - | - | $212,091 | 300 | $2,473,179 | Oct 1 | 20th Century Fox International | false |
| 27 | The Other Guys | - | - | - | $209,591 | 100 | $840,985 | Oct 22 | Sony Pictures Releasing | false |
| 28 | Takers 2010 Re-release | - | - | - | $209,160 | 100 | $680,058 | Oct 8 | Sony Pictures Releasing | false |
| 29 | Trouble at Timpetill | - | - | - | $204,741 | 114 | $440,235 | Oct 15 | Videocine | false |
| 30 | Beauty and the Beast 2010 3D Release | - | - | - | $182,792 | 20 | $367,695 | Oct 22 | Walt Disney Pictures | false |
| 31 | Unthinkable | - | - | - | $165,819 | 76 | $410,110 | Nov 12 | Gussi Films | false |
| 32 | Going the Distance | - | - | - | $136,326 | 246 | $2,152,190 | Sep 16 | Warner Bros. | false |
| 33 | Diary of a Wimpy Kid | - | - | - | $132,274 | 50 | $189,654 | Oct 29 | 20th Century Fox International | false |
| 34 | Piranha 3D | - | - | - | $130,845 | 150 | $589,805 | Oct 1 | Gussi Films | false |
| 35 | Scott Pilgrim vs. the World | - | - | - | $129,122 | 39 | $178,856 | Nov 5 | Universal Pictures International (UPI) | false |
| 36 | Management | - | - | - | $116,178 | 116 | $295,721 | Oct 22 | - | false |
| 37 | Arthur and the Revenge of Maltazard | - | - | - | $109,430 | 100 | $377,844 | Oct 1 | - | false |
| 38 | The Descent: Part 2 | - | - | - | $107,601 | 111 | $174,826 | Nov 18 | - | false |
| 39 | Cyrus | - | - | - | $74,030 | 40 | $150,996 | Nov 26 | 20th Century Fox International | false |
| 40 | Mother and Child | - | - | - | $67,840 | 120 | $323,132 | Oct 8 | - | false |
| 41 | Hidalgo. La historia jamás contada | - | - | - | $65,032 | 470 | $3,077,143 | Sep 16 | 20th Century Fox International | false |
| 42 | Resident Evil: Afterlife | - | - | - | $50,248 | 661 | $11,148,133 | Sep 16 | Sony Pictures Releasing | false |
| 43 | Rage | - | - | - | $49,246 | 37 | $80,239 | Nov 5 | Gussi Films | false |
| 44 | Avatar 2010 Special Edition | - | - | - | $38,138 | 166 | $959,054 | Oct 15 | 20th Century Fox International | false |
| 45 | Camille | - | - | - | $37,584 | 100 | $123,784 | Oct 22 | - | false |
| 46 | Speed of Glory | - | - | - | $35,479 | 100 | $35,479 | Nov 5 | - | false |
| 47 | Tell Tale | - | - | - | $30,421 | 120 | $202,660 | Sep 24 | - | false |
| 48 | Guardians of the Lost Code 3D | - | - | - | $29,907 | 250 | $975,523 | Sep 16 | Videocine | false |
| 49 | Leap Year | - | - | - | $28,573 | 10 | $131,687 | Oct 8 | - | false |
| 50 | True Heroes | - | - | - | $23,204 | 295 | $674,607 | Sep 24 | - | false |
| 51 | The Messenger | - | - | - | $20,400 | 31 | $108,870 | Oct 1 | - | false |
| 52 | Meet Bill | - | - | - | $14,417 | 100 | $128,241 | Oct 8 | - | false |
| 53 | Please Give | - | - | - | $5,358 | 10 | $72,807 | Aug 27 | Sony Pictures Releasing | false |
| 54 | La Vida Loca | - | - | - | $5,149 | 13 | $63,592 | Oct 1 | - | false |
| 55 | Vincere | - | - | - | $4,965 | 13 | $99,037 | Sep 16 | - | false |
| 56 | La fille de Monaco | - | - | - | $3,693 | 8 | $35,790 | Oct 8 | - | false |
| 57 | Micmacs | - | - | - | $3,053 | 7 | $28,061 | Sep 10 | Sony Pictures Releasing | false |
| 58 | Bug 2010 Re-release | - | - | - | $689 | 1 | $4,721 | Nov 26 | - | false |
