| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $12,759,202 | 689 | $19,017,186 | Nov 19 | Warner Bros. | false |
| 2 | Julia's Eyes | - | - | - | $6,141,602 | 365 | $9,301,221 | Oct 29 | United International Pictures | false |
| 3 | Unstoppable | - | - | - | $3,749,590 | 336 | $4,218,424 | Nov 12 | 20th Century Fox International | false |
| 4 | Due Date | - | - | - | $3,685,363 | 302 | $3,905,948 | Nov 5 | Warner Bros. | false |
| 5 | Despicable Me | - | - | - | $3,243,572 | 542 | $14,257,017 | Oct 8 | United International Pictures | false |
| 6 | The Town | - | - | - | $3,121,828 | 228 | $5,106,974 | Oct 29 | Warner Bros. | false |
| 7 | Fair Game | - | - | - | $2,996,317 | 201 | $3,410,708 | Nov 5 | DeAPlaneta | false |
| 8 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $1,749,938 | 323 | $3,527,098 | Oct 22 | Warner Bros. | false |
| 9 | Beauty and the Beast 2010 3D Release | - | - | - | $1,565,741 | 279 | $2,243,575 | Nov 19 | Walt Disney Pictures | false |
| 10 | The Social Network | - | - | - | $1,524,938 | 339 | $6,584,744 | Oct 15 | Sony Pictures Releasing | false |
| 11 | Jackass 3D | - | - | - | $1,516,221 | 243 | $1,463,857 | Nov 5 | Paramount Pictures International | false |
| 12 | Skyline | - | - | - | $1,477,915 | 345 | $3,198,153 | Nov 26 | Aurum Films | false |
| 13 | The Other Guys | - | - | - | $1,383,497 | 251 | $1,443,642 | Nov 12 | Sony Pictures Releasing | false |
| 14 | Among Wolves | - | - | - | $922,522 | 237 | $4,224,250 | Nov 26 | Wanda Visión S.A. | false |
| 15 | Takers 2010 Re-release | - | - | - | $894,088 | 204 | $2,905,445 | Nov 26 | Sony Pictures Releasing | false |
| 16 | Paranormal Activity 2 | - | - | - | $813,715 | 205 | $2,538,034 | Oct 22 | Paramount Pictures International | false |
| 17 | Agnosia | - | - | - | $796,008 | 202 | $760,672 | Nov 5 | Aurum Films | false |
| 18 | Easy A | - | - | - | $788,183 | 221 | $1,397,014 | Oct 29 | Sony Pictures Releasing | false |
| 19 | Stone | - | - | - | $737,528 | 186 | $2,296,632 | Oct 22 | Filmax | false |
| 20 | Certified Copy | - | - | - | $706,546 | 43 | $1,053,670 | Oct 29 | Wanda Visión S.A. | false |
| 21 | Bon appétit | - | - | - | $673,906 | 100 | $1,262,026 | Nov 12 | - | false |
| 22 | Heartbreaker | - | - | - | $617,698 | 157 | $1,510,738 | Oct 22 | - | false |
| 23 | Wall Street: Money Never Sleeps | - | - | - | $523,712 | 347 | $6,789,674 | Oct 8 | 20th Century Fox International | false |
| 24 | Tamara Drewe | - | - | - | $470,649 | 64 | $609,276 | Nov 12 | Alta Films | false |
| 25 | Toy Story 3 | - | - | - | $455,024 | 719 | $33,154,762 | Jul 21 | Walt Disney Pictures | false |
| 26 | Chloe | - | - | - | $405,830 | 118 | $1,379,169 | Nov 26 | - | false |
| 27 | Black Bread | - | - | - | $382,915 | 114 | $3,770,657 | Oct 15 | - | false |
| 28 | The Way 2010 Re-release | - | - | - | $346,009 | 59 | $562,021 | Nov 19 | Filmax | false |
| 29 | Let Me In | - | - | - | $320,360 | 204 | $1,216,232 | Oct 22 | Aurum Films | false |
| 30 | Inception | - | - | - | $306,572 | 497 | $22,212,764 | Aug 6 | Warner Bros. | false |
| 31 | Lock Up | - | - | - | $281,493 | 150 | $288,197 | Nov 12 | Filmax | false |
| 32 | The Sorcerer's Apprentice | - | - | - | $267,056 | 402 | $9,354,968 | Sep 3 | Walt Disney Pictures | false |
| 33 | Forever Young | - | - | - | $234,408 | 135 | $645,148 | Oct 22 | Alta Films | false |
| 34 | Scott Pilgrim vs. the World | - | - | - | $218,687 | 70 | $218,687 | Nov 12 | United International Pictures | false |
| 35 | Buried | - | - | - | $198,303 | 200 | $3,113,006 | Oct 1 | Warner Bros. | false |
| 36 | Tinker Bell and the Great Fairy Rescue | - | - | - | $192,161 | 103 | $2,094,543 | Sep 3 | Walt Disney Pictures | false |
| 37 | Eat Pray Love | - | - | - | $185,813 | 345 | $6,698,018 | Sep 24 | Sony Pictures Releasing | false |
| 38 | The Nutcrackers | - | - | - | $184,546 | 90 | $356,509 | Oct 29 | Alta Films | false |
| 39 | Saw VI | - | - | - | $162,958 | 212 | $3,300,211 | Oct 8 | DeAPlaneta | false |
| 40 | Vampires Suck | - | - | - | $130,515 | 328 | $4,698,326 | Oct 1 | 20th Century Fox International | false |
| 41 | 18 Meals | - | - | - | $129,347 | 32 | $447,674 | Nov 19 | - | false |
| 42 | Flamenco Flamenco | - | - | - | $115,797 | 29 | $303,966 | Nov 19 | Alta Films | false |
| 43 | Letters to Juliet | - | - | - | $108,975 | 258 | $1,663,590 | Oct 8 | TriPictures | false |
| 44 | You Will Meet a Tall Dark Stranger | - | - | - | $93,850 | 252 | $5,960,295 | Aug 27 | Alta Films | false |
| 45 | Ways to Live Forever | - | - | - | $87,884 | 108 | $158,693 | Oct 29 | - | false |
| 46 | Cyrus | - | - | - | $86,335 | 36 | $94,389 | Nov 19 | 20th Century Fox International | false |
| 47 | Exit Through the Gift Shop | - | - | - | $77,751 | 10 | $253,497 | Oct 8 | Avalon | false |
| 48 | Plans for Tomorrow | - | - | - | $77,497 | 30 | $133,543 | Nov 19 | - | false |
| 49 | The Mosquito Net | - | - | - | $70,896 | 23 | $126,716 | Nov 5 | - | false |
| 50 | The Outlaw | - | - | - | $67,472 | 310 | $5,040,058 | Sep 3 | 20th Century Fox International | false |
| 51 | Stars to Wish Upon | - | - | - | $66,621 | 44 | $134,802 | Oct 22 | Barton Films | false |
| 52 | My Afternoons with Margueritte | - | - | - | $64,170 | 57 | $1,030,514 | Aug 20 | Golem Distribución | false |
| 53 | La Bohème 2010 Re-release | - | - | - | $63,965 | 21 | $72,940 | Nov 5 | Karma Films | false |
| 54 | On the Path | - | - | - | $63,929 | 20 | $101,538 | Nov 12 | Golem Distribución | false |
| 55 | Carancho | - | - | - | $61,188 | 52 | $832,546 | Sep 24 | Golem Distribución | false |
| 56 | How Much Does Your Building Weigh, Mr Foster? | - | - | - | $50,181 | 5 | $150,909 | Oct 8 | - | false |
| 57 | Amador | - | - | - | $45,343 | 140 | $856,917 | Oct 8 | Alta Films | false |
| 58 | Di Di Hollywood | - | - | - | $42,263 | 235 | $1,002,398 | Oct 15 | Warner Bros. | false |
| 59 | Diary of a Wimpy Kid | - | - | - | $41,730 | 33 | $95,562 | Oct 22 | 20th Century Fox International | false |
| 60 | Bicicleta, cullera, poma | - | - | - | $40,486 | 24 | $348,747 | Oct 1 | Sagrera TV | false |
| 61 | El tesoro del rey Midas | - | - | - | $39,196 | 27 | $42,310 | Nov 5 | Barton Films | false |
| 62 | Louise hires a contract killer | - | - | - | $37,150 | 22 | $120,023 | Oct 15 | Karma Films | false |
| 63 | Avatar 2010 Special Edition | - | - | - | $33,833 | 242 | $2,687,307 | Sep 24 | 20th Century Fox International | false |
| 64 | Uncle Boonmee Who Can Recall His Past Lives | - | - | - | $30,763 | 15 | $123,310 | Nov 26 | Karma Films | false |
| 65 | Retornos | - | - | - | $30,160 | 32 | $59,247 | Oct 29 | - | false |
| 66 | Step Up 3D | - | - | - | $24,310 | 308 | $2,611,502 | Sep 17 | Walt Disney Pictures | false |
| 67 | Astro Boy | - | - | - | $22,215 | 141 | $679,352 | Sep 24 | DeAPlaneta | false |
| 68 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $20,096 | 336 | $2,710,677 | Aug 20 | Warner Bros. | false |
| 69 | My Father My Lord 2010 Re-release | - | - | - | $18,801 | 6 | $27,985 | Nov 19 | Karma Films | false |
| 70 | Circuit | - | - | - | $18,574 | 15 | $63,741 | Nov 19 | - | false |
| 71 | Poetry | - | - | - | $17,848 | 8 | $155,966 | Nov 26 | Golem Distribución | false |
| 72 | The New Daughter | - | - | - | $17,485 | 66 | $280,587 | Oct 15 | - | false |
| 73 | Che: A New Man | - | - | - | $16,206 | 11 | $26,269 | Oct 29 | Golem Distribución | false |
| 74 | The Karate Kid | - | - | - | $15,013 | 485 | $11,727,245 | Aug 27 | Sony Pictures Releasing | false |
| 75 | The Great Vazquez | - | - | - | $13,671 | 238 | $1,184,521 | Sep 24 | Alta Films | false |
| 76 | Todo lo que tú quieras | - | - | - | $13,538 | 84 | $559,874 | Sep 10 | Wanda Visión S.A. | false |
| 77 | The Extraordinary Adventures of Adèle Blanc-Sec | - | - | - | $12,349 | 227 | $1,238,875 | Sep 10 | TriPictures | false |
| 78 | Undertow | - | - | - | $11,034 | 22 | $215,789 | Sep 17 | Karma Films | false |
| 79 | Ramona and Beezus | - | - | - | $10,941 | 30 | $161,213 | Sep 17 | 20th Century Fox International | false |
| 80 | Nagore | - | - | - | $9,731 | 7 | $33,620 | Nov 12 | - | false |
| 81 | Machete | - | - | - | $8,940 | 254 | $2,003,454 | Oct 1 | Sony Pictures Releasing | false |
| 82 | Father | - | - | - | $6,392 | 9 | $6,392 | Nov 12 | Karma Films | false |
| 83 | Amerikanuak | - | - | - | $6,269 | 5 | $6,269 | Nov 19 | Barton Films | false |
| 84 | 14 Days with Victor | - | - | - | $6,126 | 4 | $37,618 | Oct 29 | - | false |
| 85 | Señora de | - | - | - | $5,542 | 3 | $5,542 | Nov 5 | - | false |
| 86 | Blood Money | - | - | - | $5,393 | 40 | $44,695 | Oct 8 | - | false |
| 87 | The Stoning of Soraya M. | - | - | - | $5,092 | 49 | $80,447 | Oct 15 | - | false |
| 88 | Grown Ups | - | - | - | $4,598 | 328 | $8,507,573 | Jul 30 | Sony Pictures Releasing | false |
| 89 | El idioma imposible | - | - | - | $4,517 | 6 | $6,414 | Nov 26 | Barton Films | false |
| 90 | Heaven on Earth 2010 Re-release | - | - | - | $4,475 | 14 | $75,119 | Oct 1 | Karma Films | false |
| 91 | Resident Evil: Afterlife | - | - | - | $4,210 | 488 | $7,800,947 | Sep 10 | Sony Pictures Releasing | false |
| 92 | Abel | - | - | - | $2,880 | 25 | $122,153 | Oct 1 | Alta Films | false |
| 93 | The American | - | - | - | $2,875 | 273 | $4,689,425 | Sep 17 | United International Pictures | false |
| 94 | Propios y extraños | - | - | - | $2,868 | 16 | $4,586 | Nov 26 | - | false |
| 95 | Charlie St. Cloud | - | - | - | $1,934 | 258 | $1,753,590 | Oct 1 | United International Pictures | false |
| 96 | Salt | - | - | - | $1,091 | 446 | $8,022,096 | Aug 20 | Sony Pictures Releasing | false |
| 97 | 3D Sun | - | - | - | $879 | 2 | $3,609 | Oct 29 | - | false |
