| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $3,025,618 | 117 | $5,864,306 | Nov 18 | Warner Bros. | false |
| 2 | Inception | - | - | - | $2,437,285 | 119 | $7,439,087 | Jul 29 | Warner Bros. | false |
| 3 | Paranormal Activity 2 | - | - | - | $1,970,738 | 59 | $2,481,483 | Nov 4 | Paramount Pictures International | false |
| 4 | Saw 3D | - | - | - | $942,576 | 71 | $1,467,534 | Oct 28 | - | false |
| 5 | Due Date | - | - | - | $653,176 | 47 | $938,241 | Nov 4 | Warner Bros. | false |
| 6 | Red | - | - | - | $422,293 | 54 | $691,246 | Oct 28 | Alfa Films | false |
| 7 | The Switch | - | - | - | $347,550 | 37 | $570,139 | Nov 11 | - | false |
| 8 | The Town | - | - | - | $270,734 | 45 | $677,594 | Oct 21 | Warner Bros. | false |
| 9 | The Social Network | - | - | - | $213,252 | 51 | $621,292 | Oct 21 | Sony Pictures Releasing | false |
| 10 | Resident Evil: Afterlife | - | - | - | $210,489 | 98 | $1,392,142 | Oct 14 | Sony Pictures Releasing | false |
| 11 | Jackass 3D | - | - | - | $184,454 | 47 | $184,454 | Nov 11 | Paramount Pictures International | false |
| 12 | Skyline | - | - | - | $173,994 | 56 | $565,237 | Nov 25 | Distribution Company | false |
| 13 | Gaturro | - | - | - | $164,292 | 107 | $533,158 | Sep 9 | Distribution Company | false |
| 14 | Agora | - | - | - | $143,543 | 17 | $202,379 | Nov 4 | Distribution Company | false |
| 15 | Life as We Know It | - | - | - | $135,673 | 43 | $650,507 | Oct 7 | Warner Bros. | false |
| 16 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $101,807 | 97 | $1,034,469 | Sep 30 | Warner Bros. | false |
| 17 | Eat Pray Love | - | - | - | $91,701 | 55 | $1,367,393 | Sep 16 | Sony Pictures Releasing | false |
| 18 | The Spy Next Door 2010 Re-release | - | - | - | $82,781 | 22 | $170,583 | Oct 21 | - | false |
| 19 | Machete | - | - | - | $73,029 | 32 | $187,600 | Nov 25 | Sony Pictures Releasing | false |
| 20 | Come Undone | - | - | - | $59,895 | 12 | $118,642 | Nov 18 | CDI Films | false |
| 21 | The Missing Lynx 2010 Re-release | - | - | - | $59,888 | 20 | $86,079 | Oct 28 | CDI Films | false |
| 22 | The American | - | - | - | $54,160 | 35 | $298,734 | Oct 14 | Universal Pictures International (UPI) | false |
| 23 | Buried | - | - | - | $52,706 | 41 | $621,758 | Oct 7 | - | false |
| 24 | The Last Exorcism | - | - | - | $39,906 | 43 | $1,144,364 | Sep 9 | - | false |
| 25 | Solomon Kane | - | - | - | $36,282 | 25 | $135,137 | Nov 25 | Alfa Films | false |
| 26 | Villa Amalia 2009 Re-release | - | - | - | $34,446 | 4 | $57,945 | Nov 11 | Alfa Films | false |
| 27 | Che: A New Man | - | - | - | $33,787 | 17 | $140,615 | Oct 7 | Distribution Company | false |
| 28 | No Return | - | - | - | $23,207 | 53 | $537,254 | Sep 30 | Distribution Company | false |
| 29 | Boca de fresa | - | - | - | $23,196 | 19 | $25,494 | Nov 11 | Primer Plano Film Group | false |
| 30 | The Kids Are All Right | - | - | - | $20,492 | 29 | $388,831 | Sep 30 | Alfa Films | false |
| 31 | The Man Next Door | - | - | - | $18,197 | 35 | $517,540 | Sep 2 | Primer Plano Film Group | false |
| 32 | Charlie St. Cloud | - | - | - | $16,597 | 35 | $234,966 | Oct 7 | Universal Pictures International (UPI) | false |
| 33 | A Woman in Berlin 2010 Re-release | - | - | - | $15,026 | 4 | $16,617 | Nov 4 | Alfa Films | false |
| 34 | Un buen día | - | - | - | $14,440 | 40 | $19,733 | Nov 18 | Distribution Company | false |
| 35 | I Love You Phillip Morris | - | - | - | $14,276 | 27 | $345,688 | Sep 23 | - | false |
| 36 | Tinker Bell and the Great Fairy Rescue | - | - | - | $14,152 | 44 | $654,232 | Sep 2 | Walt Disney Pictures | false |
| 37 | The First Day of the Rest of Your Life | - | - | - | $11,549 | 10 | $45,851 | Oct 21 | Impacto Cine | false |
| 38 | The Hedgehog | - | - | - | $7,983 | 7 | $96,422 | Sep 2 | Impacto Cine | false |
| 39 | Lengua materna | - | - | - | $7,642 | 17 | $26,394 | Oct 21 | Distribution Company | false |
| 40 | Wall Street: Money Never Sleeps | - | - | - | $7,350 | 57 | $533,972 | Sep 23 | 20th Century Fox International | false |
| 41 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $7,173 | 112 | $1,415,974 | Aug 19 | Warner Bros. | false |
| 42 | Avatar 2010 Special Edition | - | - | - | $7,045 | 50 | $572,030 | Sep 23 | 20th Century Fox International | false |
| 43 | A Rational Solution | - | - | - | $5,768 | 4 | $11,781 | Oct 28 | Primer Plano Film Group | false |
| 44 | Despicable Me | - | - | - | $4,138 | 146 | $2,878,027 | Jul 29 | Universal Pictures International (UPI) | false |
| 45 | Everlasting Moments 2010 Re-release | - | - | - | $3,954 | 4 | $30,507 | Oct 7 | Alfa Films | false |
| 46 | The Tango Singer | - | - | - | $3,068 | 3 | $3,273 | Nov 11 | - | false |
| 47 | Amreeka | - | - | - | $2,988 | 6 | $10,089 | Oct 28 | IFA | false |
| 48 | The Last Airbender | - | - | - | $2,519 | 115 | $2,760,838 | Aug 12 | Paramount Pictures International | false |
| 49 | Babies | - | - | - | $1,216 | 5 | $3,659 | Oct 28 | Distribution Company | false |
