| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: New Moon | - | - | - | $19,052,311 | 636 | $28,617,897 | Nov 20 | Aurum Films | false |
| 2 | 2012 | - | - | - | $17,384,438 | 606 | $22,591,580 | Nov 13 | Sony Pictures Releasing | false |
| 3 | Cell 211 | - | - | - | $7,889,753 | 220 | $15,905,730 | Nov 6 | Paramount Pictures International | false |
| 4 | A Christmas Carol | - | - | - | $6,370,540 | 427 | $8,321,029 | Nov 13 | Walt Disney Pictures | false |
| 5 | Agora | - | - | - | $5,795,225 | 478 | $29,609,470 | Oct 9 | 20th Century Fox International | false |
| 6 | Planet 51 | - | - | - | $4,342,884 | 509 | $15,762,612 | Nov 27 | DeAPlaneta | false |
| 7 | Hachi: A Dog's Tale | - | - | - | $3,080,944 | 228 | $3,080,944 | Nov 6 | United International Pictures | false |
| 8 | The Girl Who Played with Fire | - | - | - | $2,849,844 | 360 | $7,772,456 | Oct 23 | Vértigo Films | false |
| 9 | G-Force | - | - | - | $2,444,699 | 482 | $12,966,370 | Oct 9 | Walt Disney Pictures | false |
| 10 | Julie & Julia | - | - | - | $2,441,174 | 206 | $2,597,806 | Nov 6 | Sony Pictures Releasing | false |
| 11 | The Box | - | - | - | $2,400,035 | 262 | $2,400,035 | Nov 6 | Warner Bros. | false |
| 12 | This Is It | - | - | - | $2,327,754 | 377 | $5,010,725 | Oct 28 | Sony Pictures Releasing | false |
| 13 | The Final Destination | - | - | - | $2,236,848 | 324 | $4,120,952 | Oct 30 | TriPictures | false |
| 14 | The Ugly Truth | - | - | - | $1,457,812 | 360 | $7,800,185 | Oct 16 | Sony Pictures Releasing | false |
| 15 | Amelia | - | - | - | $1,390,194 | 301 | $1,644,943 | Nov 20 | 20th Century Fox International | false |
| 16 | Pandorum | - | - | - | $1,037,315 | 256 | $1,037,315 | Nov 6 | DeAPlaneta | false |
| 17 | Whatever Works | - | - | - | $1,001,332 | 196 | $5,590,384 | Oct 2 | TriPictures | false |
| 18 | Paranormal Activity | - | - | - | $995,186 | 205 | $2,679,752 | Nov 27 | Warner Bros. | false |
| 19 | Up | - | - | - | $691,219 | 603 | $37,052,520 | Jul 30 | Walt Disney Pictures | false |
| 20 | Vicky the Viking | - | - | - | $650,594 | 358 | $5,237,616 | Oct 2 | Aurum Films | false |
| 21 | The Dancer and the Thief | - | - | - | $639,575 | 200 | $2,172,688 | Nov 27 | Notro Films | false |
| 22 | 500 Days of Summer | - | - | - | $580,023 | 151 | $1,541,806 | Oct 23 | 20th Century Fox International | false |
| 23 | Inglourious Basterds | - | - | - | $520,625 | 482 | $15,418,489 | Sep 18 | United International Pictures | false |
| 24 | The Imaginarium of Doctor Parnassus | - | - | - | $518,535 | 71 | $1,342,851 | Oct 23 | Sony Pictures Releasing | false |
| 25 | Ice Age: Dawn of the Dinosaurs | - | - | - | $503,846 | 663 | $32,142,485 | Jul 2 | 20th Century Fox International | false |
| 26 | Toy Story 2009 Re-release | - | - | - | $335,010 | 73 | $1,195,405 | Oct 23 | Walt Disney Pictures | false |
| 27 | Harry Potter and the Half-Blood Prince | - | - | - | $324,679 | 589 | $20,813,480 | Jul 15 | Warner Bros. | false |
| 28 | Gran Torino | - | - | - | $296,760 | 263 | $19,038,938 | Mar 6 | Warner Bros. | false |
| 29 | Triage | - | - | - | $289,418 | 132 | $289,418 | Nov 13 | Alta Films | false |
| 30 | Orphan | - | - | - | $282,266 | 264 | $2,713,843 | Oct 16 | Warner Bros. | false |
| 31 | Leaving | - | - | - | $251,210 | 34 | $251,210 | Nov 13 | Golem Distribución | false |
| 32 | The Girl with the Dragon Tattoo | - | - | - | $227,674 | 283 | $13,727,644 | May 29 | Vértigo Films | false |
| 33 | Surrogates | - | - | - | $223,417 | 320 | $6,176,221 | Sep 25 | Walt Disney Pictures | false |
| 34 | Tenderness | - | - | - | $185,134 | 54 | $185,134 | Nov 20 | Manga Entertainment | false |
| 35 | [Rec]² | - | - | - | $183,244 | 356 | $7,684,043 | Oct 2 | Filmax | false |
| 36 | The Hangover | - | - | - | $147,847 | 327 | $9,374,796 | Aug 14 | Warner Bros. | false |
| 37 | Away We Go | - | - | - | $143,291 | 13 | $143,291 | Nov 20 | United International Pictures | false |
| 38 | New York, I Love You | - | - | - | $124,232 | 100 | $935,198 | Oct 16 | TriPictures | false |
| 39 | Carriers | - | - | - | $106,350 | 165 | $1,400,982 | Oct 16 | DeAPlaneta | false |
| 40 | He's Just Not That Into You | - | - | - | $106,202 | 336 | $6,788,630 | Sep 3 | TriPictures | false |
| 41 | Aliens in the Attic | - | - | - | $89,501 | 324 | $5,465,811 | Aug 14 | 20th Century Fox International | false |
| 42 | My Bloody Valentine | - | - | - | $72,219 | 310 | $4,593,087 | Sep 11 | TriPictures | false |
| 43 | The Cloud Painting Machine | - | - | - | $67,956 | 30 | $170,809 | Oct 2 | Paramount Pictures International | false |
| 44 | 3some | - | - | - | $67,271 | 59 | $146,685 | Oct 30 | Alta Films | false |
| 45 | Case 39 | - | - | - | $60,755 | 221 | $3,837,870 | Aug 28 | Paramount Pictures International | false |
| 46 | Moon | - | - | - | $55,890 | 30 | $451,359 | Oct 9 | Sony Pictures Releasing | false |
| 47 | Sin Nombre | - | - | - | $53,545 | 40 | $124,832 | Oct 30 | United International Pictures | false |
| 48 | Map of the Sounds of Tokyo | - | - | - | $50,520 | 170 | $2,990,991 | Aug 28 | Alta Films | false |
| 49 | Fat People | - | - | - | $49,975 | 176 | $2,664,834 | Sep 11 | Alta Films | false |
| 50 | Me Too | - | - | - | $44,994 | 100 | $440,170 | Oct 16 | Golem Distribución | false |
| 51 | After | - | - | - | $44,637 | 123 | $330,713 | Oct 23 | Alta Films | false |
| 52 | Katyn | - | - | - | $38,064 | 28 | $373,978 | Oct 9 | Karma Films | false |
| 53 | Home | - | - | - | $32,489 | 22 | $66,246 | Oct 30 | - | false |
| 54 | A la deriva | - | - | - | $32,066 | 26 | $32,066 | Nov 6 | - | false |
| 55 | Trash | - | - | - | $31,765 | 26 | $58,156 | Oct 30 | - | false |
| 56 | Shorts | - | - | - | $30,516 | 165 | $1,754,478 | Aug 28 | Warner Bros. | false |
| 57 | Little Indi | - | - | - | $24,203 | 14 | $47,047 | Oct 30 | - | false |
| 58 | Adam | - | - | - | $23,601 | 30 | $52,039 | Oct 30 | 20th Century Fox International | false |
| 59 | The Frost | - | - | - | $23,478 | 18 | $71,023 | Oct 16 | Independent Films | false |
| 60 | OceanWorld | - | - | - | $22,963 | 118 | $938,228 | Sep 25 | Wanda Visión S.A. | false |
| 61 | Adventureland | - | - | - | $22,550 | 30 | $22,550 | Nov 27 | Walt Disney Pictures | false |
| 62 | My Neighbor Totoro 2009 Re-release | - | - | - | $19,944 | 5 | $35,835 | Oct 30 | Aurum Films | false |
| 63 | Eden Is West | - | - | - | $18,898 | 18 | $99,470 | Oct 23 | Wanda Visión S.A. | false |
| 64 | Departures | - | - | - | $16,154 | 35 | $726,311 | Jul 3 | Golem Distribución | false |
| 65 | Frozen River | - | - | - | $15,735 | 36 | $722,067 | Sep 4 | Sagrera TV | false |
| 66 | Paris | - | - | - | $14,758 | 50 | $317,716 | Oct 9 | Vértigo Films | false |
| 67 | The Informant! | - | - | - | $13,705 | 104 | $789,433 | Sep 25 | Warner Bros. | false |
| 68 | Still Walking | - | - | - | $12,611 | 4 | $386,649 | Jun 5 | Golem Distribución | false |
| 69 | A Clockwork Orange 2009 Re-release | - | - | - | $6,326 | 10 | $35,485 | Oct 23 | Warner Bros. | false |
| 70 | Let's Get Lost 2009 Re-release | - | - | - | $5,030 | 3 | $99,046 | Sep 18 | Avalon | false |
| 71 | Dance Flick | - | - | - | $4,107 | 8 | $13,935 | Oct 30 | Paramount Pictures International | false |
| 72 | The Limits of Control | - | - | - | $3,582 | 6 | $95,120 | Oct 2 | TriPictures | false |
| 73 | Shevernatze un ángel corrupto | - | - | - | $1,988 | 55 | $9,285 | Oct 23 | - | false |
| 74 | Giant | - | - | - | $1,779 | 16 | $58,207 | Oct 2 | Golem Distribución | false |
| 75 | Imagine That | - | - | - | $1,570 | 20 | $35,573 | Oct 9 | Paramount Pictures International | false |
| 76 | Hollywood contra Franco | - | - | - | $922 | 12 | $11,361 | Oct 16 | - | false |
| 77 | Year One | - | - | - | $910 | 222 | $4,173,713 | Aug 28 | Sony Pictures Releasing | false |
| 78 | Mònica del Raval | - | - | - | $677 | 4 | $11,893 | Oct 9 | - | false |
| 79 | Guts | - | - | - | $483 | 166 | $1,023,161 | Sep 4 | Sony Pictures Releasing | false |
| 80 | La Vida Loca | - | - | - | $120 | 7 | $164 | Oct 30 | - | false |
