| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Quantum of Solace | - | - | - | $5,461,033 | 504 | $6,049,122 | Nov 14 | Sony Pictures Releasing | false |
| 2 | Twilight | - | - | - | $5,346,779 | 580 | $9,842,699 | Nov 21 | Corazón Films | false |
| 3 | High School Musical 3: Senior Year | - | - | - | $4,651,549 | 535 | $4,396,904 | Oct 31 | Walt Disney Pictures | false |
| 4 | X-mas, Inc. | - | - | - | $3,112,130 | 600 | $3,567,935 | Nov 14 | Warner Bros. | false |
| 5 | Death Race | - | - | - | $1,285,021 | 197 | $1,452,336 | Oct 31 | Universal Pictures International (UPI) | false |
| 6 | Mr. Magorium's Wonder Emporium | - | - | - | $1,182,677 | 203 | $1,285,173 | Nov 7 | Zima Entertainment | false |
| 7 | Burn After Reading | - | - | - | $1,159,815 | 250 | $1,863,287 | Oct 24 | Universal Pictures International (UPI) | false |
| 8 | Pride and Glory | - | - | - | $1,156,969 | 200 | $1,345,250 | Nov 7 | Gussi Films | false |
| 9 | Beverly Hills Chihuahua | - | - | - | $846,416 | 450 | $7,660,801 | Oct 3 | Walt Disney Pictures | false |
| 10 | Max Payne | - | - | - | $800,421 | 300 | $1,406,445 | Oct 24 | 20th Century Fox International | false |
| 11 | The House Bunny | - | - | - | $796,869 | 225 | $1,485,699 | Oct 24 | Sony Pictures Releasing | false |
| 12 | Saw V | - | - | - | $711,733 | 120 | $1,029,677 | Oct 31 | Walt Disney Pictures | false |
| 13 | Body of Lies | - | - | - | $689,608 | 327 | $2,147,839 | Nov 28 | Warner Bros. | false |
| 14 | My Mom's New Boyfriend | - | - | - | $524,014 | 167 | $1,284,003 | Oct 10 | Zima Entertainment | false |
| 15 | Under the Salt | - | - | - | $511,417 | 300 | $1,577,437 | Oct 17 | Warner Bros. | false |
| 16 | Blindness | - | - | - | $472,162 | 139 | $1,186,307 | Oct 17 | 20th Century Fox International | false |
| 17 | Mamma Mia! | - | - | - | $448,988 | 358 | $3,133,862 | Sep 12 | Universal Pictures International (UPI) | false |
| 18 | The Air I Breathe | - | - | - | $343,378 | 142 | $759,020 | Oct 17 | Videocine | false |
| 19 | Space Chimps | - | - | - | $326,995 | 200 | $669,602 | Oct 24 | Corazón Films | false |
| 20 | Death Defying Acts | - | - | - | $317,231 | 95 | $608,600 | Nov 21 | Gussi Films | false |
| 21 | Tear This Heart Out | - | - | - | $292,962 | 500 | $9,042,087 | Sep 12 | 20th Century Fox International | false |
| 22 | REC | - | - | - | $286,056 | 205 | $5,199,431 | Aug 29 | Videocine | false |
| 23 | Deception | - | - | - | $279,625 | 98 | $331,631 | Nov 7 | Corazón Films | false |
| 24 | Traitor | - | - | - | $269,980 | 121 | $543,001 | Oct 17 | Gussi Films | false |
| 25 | Be Kind Rewind | - | - | - | $261,589 | 79 | $358,400 | Oct 31 | Videocine | false |
| 26 | Impy's Island | - | - | - | $250,932 | 74 | $415,245 | Nov 14 | Gussi Films | false |
| 27 | Eagle Eye | - | - | - | $247,209 | 328 | $2,793,150 | Sep 26 | Paramount Pictures International | false |
| 28 | Disaster Movie | - | - | - | $238,267 | 200 | $767,410 | Nov 28 | Gussi Films | false |
| 29 | Swing Vote | - | - | - | $226,501 | 97 | $312,283 | Nov 7 | Quality Films | false |
| 30 | Spam | - | - | - | $214,537 | 225 | $507,148 | Oct 24 | Corazón Films | false |
| 31 | The Bank Job | - | - | - | $209,629 | 81 | $1,806,999 | Aug 29 | Gussi Films | false |
| 32 | Donkey Xote | - | - | - | $194,142 | 222 | $2,540,000 | Sep 12 | Videocine | false |
| 33 | Kada kien su karma | - | - | - | $185,550 | 101 | $387,077 | Oct 10 | Universal Pictures International (UPI) | false |
| 34 | Step Brothers | - | - | - | $177,307 | 100 | $710,254 | Sep 26 | Sony Pictures Releasing | false |
| 35 | The Duchess | - | - | - | $160,540 | 28 | $509,855 | Nov 21 | Paramount Pictures International | false |
| 36 | The Killing Gene | - | - | - | $138,223 | 73 | $155,775 | Oct 31 | Quality Films | false |
| 37 | Divina confusión | - | - | - | $131,744 | 211 | $887,620 | Sep 26 | Videocine | false |
| 38 | Rogue | - | - | - | $130,547 | 50 | $381,975 | Sep 19 | Gussi Films | false |
| 39 | Fly Me to the Moon 3D | - | - | - | $122,951 | 17 | $2,165,400 | Mar 9 | Gussi Films | false |
| 40 | The Women | - | - | - | $118,662 | 100 | $465,445 | Nov 28 | Universal Pictures International (UPI) | false |
| 41 | Satanás | - | - | - | $117,206 | 43 | $133,804 | Oct 31 | Gussi Films | false |
| 42 | Wild Child | - | - | - | $76,140 | 120 | $348,673 | Nov 28 | Paramount Pictures International | false |
| 43 | The Boy in the Striped Pajamas | - | - | - | $74,785 | 35 | $959,188 | Nov 28 | Walt Disney Pictures | false |
| 44 | Dedication 2008 Re-release | - | - | - | $74,112 | 50 | $157,329 | Oct 10 | Quality Films | false |
| 45 | Funny Games | - | - | - | $64,277 | 45 | $265,499 | Sep 26 | Universal Pictures International (UPI) | false |
| 46 | The Last Legion | - | - | - | $63,274 | 80 | $897,002 | Aug 29 | Zima Entertainment | false |
| 47 | The Strangers | - | - | - | $62,730 | 194 | $2,853,234 | Sep 19 | Videocine | false |
| 48 | Balls of Fury | - | - | - | $57,866 | 50 | $105,855 | Nov 7 | Gussi Films | false |
| 49 | The Forbidden Kingdom | - | - | - | $57,772 | 207 | $1,924,003 | Sep 12 | Zima Entertainment | false |
| 50 | Teo's Journey | - | - | - | $55,082 | 100 | $147,474 | Oct 10 | Videocine | false |
| 51 | Pineapple Express | - | - | - | $53,438 | 50 | $148,200 | Oct 10 | Sony Pictures Releasing | false |
| 52 | Lakeview Terrace | - | - | - | $50,580 | 50 | $295,116 | Nov 21 | Sony Pictures Releasing | false |
| 53 | Forgetting Sarah Marshall | - | - | - | $46,403 | 139 | $884,945 | Sep 19 | Universal Pictures International (UPI) | false |
| 54 | Tinker Bell | - | - | - | $41,826 | 220 | $3,148,867 | Sep 19 | Walt Disney Pictures | false |
| 55 | The Condemned | - | - | - | $38,802 | 68 | $222,054 | Oct 10 | Corazón Films | false |
| 56 | The Unknown Woman | - | - | - | $32,296 | 14 | $107,052 | Nov 7 | Quality Films | false |
| 57 | Nights in Rodanthe | - | - | - | $29,921 | 236 | $1,900,304 | Oct 3 | Warner Bros. | false |
| 58 | Mirrors | - | - | - | $29,538 | 367 | $3,961,078 | Oct 3 | 20th Century Fox International | false |
| 59 | The Ugly Duckling and Me! | - | - | - | $28,406 | 77 | $402,200 | Aug 29 | Quality Films | false |
| 60 | Unrest | - | - | - | $27,601 | 40 | $931,993 | Mar 28 | - | false |
| 61 | Frozen River | - | - | - | $26,068 | 7 | $74,384 | Nov 7 | Sony Pictures Releasing | false |
| 62 | The Host | - | - | - | $18,879 | 39 | $157,501 | Sep 5 | Gussi Films | false |
| 63 | Molière | - | - | - | $17,216 | 20 | $182,993 | Sep 5 | Universal Pictures International (UPI) | false |
| 64 | An American Crime | - | - | - | $16,966 | 50 | $587,884 | Aug 8 | Quality Films | false |
| 65 | Blonde and Blonder | - | - | - | $15,623 | 40 | $102,424 | Oct 3 | Quality Films | false |
| 66 | My Brother 2008 Re-release | - | - | - | $15,345 | 17 | $84,690 | Nov 7 | - | false |
| 67 | Espérame en otro mundo | - | - | - | $14,522 | 30 | $54,560 | Oct 24 | Videocine | false |
| 68 | A Soap 2008 Re-release | - | - | - | $12,823 | 6 | $34,958 | Oct 17 | Alphaville | false |
| 69 | Hunting and Gathering | - | - | - | $12,240 | 13 | $58,344 | Oct 31 | Cinemas Nueva Era | false |
| 70 | Los campeones de la lucha libre | - | - | - | $12,080 | 357 | $406,994 | Oct 17 | - | false |
| 71 | The Other Boleyn Girl | - | - | - | $9,993 | 69 | $1,798,046 | Aug 8 | Gussi Films | false |
| 72 | 24 Frames of Terror | - | - | - | $9,031 | 16 | $68,919 | Nov 14 | - | false |
| 73 | Lake Tahoe | - | - | - | $8,820 | 13 | $35,310 | Nov 28 | - | false |
| 74 | Anna M. | - | - | - | $5,228 | 9 | $49,298 | Sep 12 | Alphaville | false |
| 75 | Apartment 1303 | - | - | - | $4,826 | 40 | $282,838 | Oct 17 | Alphaville | false |
| 76 | Red Like the Sky 2008 Re-release | - | - | - | $4,488 | 20 | $117,098 | Aug 15 | Quality Films | false |
| 77 | La capture | - | - | - | $4,329 | 13 | $80,624 | Oct 17 | - | false |
| 78 | Charlie Bartlett | - | - | - | $4,289 | 80 | $134,229 | Oct 3 | Azteca Films | false |
| 79 | The Last Mistress | - | - | - | $3,869 | 4 | $22,885 | Nov 28 | Cinemas Nueva Era | false |
| 80 | Mad Money | - | - | - | $3,603 | 100 | $832,400 | Aug 15 | Corazón Films | false |
| 81 | Sex and Death 101 | - | - | - | $3,394 | 50 | $193,199 | Aug 22 | Quality Films | false |
| 82 | The Diving Bell and the Butterfly | - | - | - | $3,352 | 18 | $351,504 | Jun 20 | Gussi Films | false |
| 83 | Sea Monsters: A Prehistoric Adventure | - | - | - | $3,218 | 1 | $29,312 | Sep 26 | National Geographic Cinema Ventures | false |
| 84 | Planet Terror | - | - | - | $2,993 | 8 | $75,255 | Jun 13 | Zima Entertainment | false |
| 85 | 40 días | - | - | - | $2,910 | 20 | $26,891 | Oct 3 | Gussi Films | false |
| 86 | Private Fears in Public Places | - | - | - | $2,811 | 10 | $201,400 | Jun 27 | Alphaville | false |
| 87 | Nesio | - | - | - | $2,773 | 12 | $14,714 | Oct 24 | Film House | false |
| 88 | Pamela por amor | - | - | - | $2,736 | 15 | $99,016 | Sep 5 | - | false |
| 89 | Irina Palm | - | - | - | $2,727 | 11 | $260,615 | May 30 | Zima Entertainment | false |
| 90 | Bajo Juárez: La ciudad devorando a sus hijas | - | - | - | $2,654 | 16 | $75,443 | Oct 3 | - | false |
| 91 | College Road Trip | - | - | - | $2,590 | 150 | $2,862,598 | Aug 8 | Walt Disney Pictures | false |
| 92 | 4 Months, 3 Weeks and 2 Days | - | - | - | $2,583 | 12 | $143,501 | Apr 18 | Zima Entertainment | false |
| 93 | Las vidas de Celia | - | - | - | $2,220 | 12 | $34,471 | May 1 | Alphaville | false |
| 94 | Valentina: The Movie | - | - | - | $2,216 | 9 | $197,818 | - | - | false |
| 95 | Timbiriche: La misma piedra | - | - | - | $1,929 | 28 | $25,488 | Nov 28 | Alphaville | false |
| 96 | It's Better If Gabriela Doesn't Die | - | - | - | $1,903 | 113 | $57,962 | Sep 19 | Corazón Films | false |
| 97 | Death Proof | - | - | - | $1,893 | 9 | $140,116 | May 23 | Zima Entertainment | false |
| 98 | Death of a President | - | - | - | $1,852 | 9 | $76,000 | Jul 4 | Quality Films | false |
| 99 | Honeydripper | - | - | - | $1,827 | 10 | $14,447 | Oct 10 | David Distribucion | false |
| 100 | P2 | - | - | - | $1,487 | 138 | $732,996 | Dec 14 | Zima Entertainment | false |
| 101 | Tideland | - | - | - | $1,434 | 2 | $19,103 | Oct 10 | - | false |
| 102 | Never Back Down | - | - | - | $1,414 | 140 | $331,144 | Aug 22 | Corazón Films | false |
| 103 | Ira & Abby | - | - | - | $1,286 | 40 | $244,002 | May 9 | Corazón Films | false |
| 104 | Babylon A.D. | - | - | - | $1,179 | 300 | $3,375,100 | Sep 5 | 20th Century Fox International | false |
| 105 | Hasta la muerte | - | - | - | $1,167 | 35 | $165,007 | May 16 | Azteca Films | false |
| 106 | La sangre iluminada | - | - | - | $1,123 | 15 | $18,699 | Apr 25 | MV Films | false |
| 107 | Twisted Souls | - | - | - | $1,106 | 6 | $83,329 | Jan 11 | - | false |
| 108 | The Wind that Shakes the Barley 2008 Re-release | - | - | - | $1,102 | 1 | $3,257 | Nov 28 | Quality Films | false |
| 109 | Familia tortuga | - | - | - | $1,022 | 4 | $8,661 | Oct 31 | Canana Films | false |
| 110 | Harold & Kumar Escape from Guantanamo Bay | - | - | - | $1,015 | 60 | $173,401 | Aug 22 | Gussi Films | false |
| 111 | Todos los días son tuyos | - | - | - | $997 | 101 | $108,250 | Aug 29 | Corazón Films | false |
| 112 | Íntimamente entre amigas | - | - | - | $910 | 9 | $21,976 | Sep 19 | - | false |
| 113 | Semi-Pro | - | - | - | $835 | 30 | $45,546 | Sep 12 | Gussi Films | false |
| 114 | Tell No One | - | - | - | $792 | 15 | $85,442 | Apr 11 | Cinemas Nueva Era | false |
| 115 | The Sugar Curtain | - | - | - | $728 | 2 | $6,961 | Oct 10 | - | false |
| 116 | Sleuth | - | - | - | $689 | 6 | $201,890 | Jan 25 | Sony Pictures Releasing | false |
| 117 | Mezcal | - | - | - | $543 | 5 | $32,224 | Jun 15 | Instituto Mexicano de Cinematografía (IMCINE) | false |
| 118 | Trivial | - | - | - | $474 | 14 | $59,176 | Feb 8 | - | false |
| 119 | Reservation Road | - | - | - | $336 | 20 | $109,622 | Aug 22 | Zima Entertainment | false |
| 120 | Control | - | - | - | $323 | 25 | $84,739 | Apr 4 | MV Films | false |
| 121 | Martian Child | - | - | - | $321 | 35 | $423,801 | Apr 11 | Gussi Films | false |
| 122 | High School Musical: El Desafío | - | - | - | $309 | 400 | $4,262,784 | Sep 5 | Walt Disney Pictures | false |
| 123 | You, the Living | - | - | - | $295 | 2 | $12,611 | Sep 26 | MAC Releasing | false |
| 124 | Cocalero 2008 Re-release | - | - | - | $279 | 4 | $15,750 | Sep 5 | - | false |
| 125 | See No Evil | - | - | - | $274 | 40 | $212,400 | May 23 | Gussi Films | false |
| 126 | Factory Girl | - | - | - | $265 | 10 | $122,367 | May 1 | Film House | false |
| 127 | Kung Fu Panda | - | - | - | $264 | 431 | $22,002,301 | Jun 20 | Paramount Pictures International | false |
| 128 | Persepolis | - | - | - | $254 | 5 | $160,500 | Jun 6 | Film House | false |
| 129 | The Wedding Weekend | - | - | - | $203 | 3 | $5,373 | Apr 25 | Zima Entertainment | false |
| 130 | Into Great Silence 2008 Re-release | - | - | - | $191 | 4 | $27,580 | Jul 11 | Zima Entertainment | false |
| 131 | Under the Same Moon | - | - | - | $187 | 370 | $9,577,733 | Mar 20 | 20th Century Fox International | false |
| 132 | Chapter 27 | - | - | - | $186 | 15 | $107,443 | Aug 1 | Film House | false |
| 133 | Cumbia callera | - | - | - | $181 | 20 | $27,594 | Aug 22 | Instituto Mexicano de Cinematografía (IMCINE) | false |
| 134 | Into the Wild | - | - | - | $162 | 10 | $180,405 | Apr 11 | Paramount Pictures International | false |
| 135 | In the Valley of Elah | - | - | - | $133 | 40 | $560,344 | Jan 11 | Zima Entertainment | false |
| 136 | The Bucket List | - | - | - | $128 | 250 | $6,582,890 | Jan 25 | Warner Bros. | false |
| 137 | So Ambitious 2008 Re-release | - | - | - | $127 | 9 | $68,089 | Jul 25 | Cinemas Nueva Era | false |
| 138 | Quatre étoiles 2008 Re-release | - | - | - | $112 | 12 | $23,787 | Aug 22 | Cinemas Nueva Era | false |
| 139 | Ópera | - | - | - | $102 | 7 | $7,787 | Sep 19 | - | false |
| 140 | Dan in Real Life | - | - | - | $95 | 148 | $553,104 | Sep 5 | Videocine | false |
| 141 | Used Parts | - | - | - | $78 | 25 | $52,428 | Apr 18 | Canana Films | false |
| 142 | Flawless | - | - | - | $76 | 71 | $1,000,041 | Jun 27 | Gussi Films | false |
| 143 | El brindis | - | - | - | $71 | 82 | $133,431 | Apr 25 | David Distribucion | false |
| 144 | Frontier(s) | - | - | - | $43 | 39 | $358,000 | May 9 | Zima Entertainment | false |
| 145 | Casi divas | - | - | - | $36 | 350 | $3,693,136 | Apr 11 | Sony Pictures Releasing | false |
| 146 | La frontera infinita | - | - | - | $18 | 1 | $1,849 | Oct 24 | Instituto Mexicano de Cinematografía (IMCINE) | false |
| 147 | The Secret | - | - | - | $5 | 120 | $373,145 | Jan 25 | Azteca Films | false |
