| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Quantum of Solace | - | - | - | $252,891 | 10 | $283,981 | Nov 7 | ACME | false |
| 2 | Madagascar: Escape 2 Africa | - | - | - | $210,776 | 10 | $748,906 | Nov 28 | Universal Pictures International (UPI) | false |
| 3 | Saw V | - | - | - | $151,380 | 7 | $174,527 | Oct 31 | ACME | false |
| 4 | The House Bunny | - | - | - | $119,425 | 6 | $127,295 | Oct 31 | ACME | false |
| 5 | Vicky Cristina Barcelona | - | - | - | $106,577 | 7 | $108,679 | Nov 14 | ACME | false |
| 6 | Nights in Rodanthe | - | - | - | $92,044 | 6 | $113,159 | Oct 29 | Garsu Pasaulio Irasai | false |
| 7 | Sex Drive | - | - | - | $73,958 | 6 | $138,450 | Oct 24 | ACME | false |
| 8 | Body of Lies | - | - | - | $59,122 | 7 | $87,918 | Nov 21 | Garsu Pasaulio Irasai | false |
| 9 | Quarantine | - | - | - | $29,958 | 7 | $81,699 | Nov 28 | ACME | false |
| 10 | The Ghost | - | - | - | $28,161 | 5 | $31,719 | Nov 21 | ACME | false |
| 11 | High School Musical 3: Senior Year | - | - | - | $24,270 | 7 | $92,436 | Oct 24 | Universal Pictures International (UPI) | false |
| 12 | Lakeview Terrace | - | - | - | $21,917 | 3 | $22,261 | Nov 14 | ACME | false |
| 13 | My Best Friend's Girl | - | - | - | $19,971 | 6 | $193,142 | Oct 10 | ACME | false |
| 14 | Burn After Reading | - | - | - | $19,134 | 6 | $141,987 | Oct 3 | ACME | false |
| 15 | Max Payne | - | - | - | $17,950 | 7 | $176,225 | Oct 17 | Universal Pictures International (UPI) | false |
| 16 | Pineapple Express | - | - | - | $16,777 | 6 | $89,957 | Oct 17 | ACME | false |
| 17 | The Balcony | - | - | - | $12,257 | 4 | $57,945 | Oct 17 | - | false |
| 18 | Admiral | - | - | - | $11,175 | 4 | $68,746 | Oct 10 | ACME | false |
| 19 | Elegy | - | - | - | $9,638 | 2 | $22,236 | Oct 24 | ACME | false |
| 20 | Eagle Eye | - | - | - | $9,172 | 7 | $115,271 | Oct 3 | Universal Pictures International (UPI) | false |
| 21 | How to Lose Friends & Alienate People | - | - | - | $9,146 | 1 | $9,146 | Nov 14 | - | false |
| 22 | Mesrine: Killer Instinct | - | - | - | $7,712 | 4 | $14,510 | Nov 28 | MEED Films | false |
| 23 | WALL·E | - | - | - | $6,860 | 10 | $420,941 | Jul 18 | Universal Pictures International (UPI) | false |
| 24 | Sukiyaki Western Django | - | - | - | $6,146 | 1 | $6,520 | Nov 7 | Universal Pictures International (UPI) | false |
| 25 | Perpetuum Mobile | - | - | - | $5,311 | 4 | $5,311 | Nov 7 | ACME | false |
| 26 | Outlander | - | - | - | $3,653 | 3 | $12,475 | Oct 24 | ACME | false |
| 27 | Ice Age 2: The Meltdown | - | - | - | $1,549 | 3 | $665,174 | Apr 7 | Universal Pictures International (UPI) | false |
| 28 | Ratatouille | - | - | - | $1,138 | 1 | $636,521 | Aug 17 | Universal Pictures International (UPI) | false |
| 29 | Elite Squad | - | - | - | $1,058 | 2 | $27,423 | Oct 10 | ACME | false |
| 30 | Death Race | - | - | - | $709 | 7 | $212,587 | Sep 26 | Universal Pictures International (UPI) | false |
| 31 | Kung Fu Panda | - | - | - | $292 | 9 | $483,946 | Jun 6 | Universal Pictures International (UPI) | false |
| 32 | Journey to the Center of the Earth | - | - | - | $215 | 5 | $156,432 | Aug 15 | Garsu Pasaulio Irasai | false |
| 33 | Star Wars: The Clone Wars | - | - | - | $129 | 6 | $23,153 | Sep 26 | Garsu Pasaulio Irasai | false |
| 34 | Glory to the Filmmaker! | - | - | - | $20 | 2 | $4,405 | Sep 12 | - | false |
| 35 | Mamma Mia! | - | - | - | $9 | 7 | $301,807 | Jul 18 | Universal Pictures International (UPI) | false |
