| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | High School Musical 3: Senior Year | - | - | - | $11,541,481 | 493 | $12,738,501 | Oct 31 | Walt Disney Pictures | false |
| 2 | Twilight | - | - | - | $9,827,154 | 551 | $14,410,854 | Nov 21 | Eagle Pictures | false |
| 3 | Quantum of Solace | - | - | - | $8,784,065 | 491 | $9,174,615 | Nov 7 | Sony Pictures Releasing | false |
| 4 | La fidanzata di papà | - | - | - | $7,639,567 | 525 | $9,471,031 | Nov 14 | Medusa Distribuzione | false |
| 5 | Kung Fu Panda | - | - | - | $3,826,633 | 669 | $22,037,818 | Aug 29 | Universal Pictures International (UPI) | false |
| 6 | WALL·E | - | - | - | $3,649,314 | 592 | $12,210,993 | Oct 17 | Walt Disney Pictures | false |
| 7 | Welcome to the Sticks | - | - | - | $3,577,914 | 325 | $4,245,593 | Oct 31 | Medusa Distribuzione | false |
| 8 | Body of Lies | - | - | - | $3,547,751 | 357 | $6,005,344 | Nov 21 | Warner Bros. | false |
| 9 | Tropic Thunder | - | - | - | $2,378,537 | 297 | $4,624,397 | Oct 24 | Universal Pictures International (UPI) | false |
| 10 | Vicky Cristina Barcelona | - | - | - | $2,307,129 | 383 | $8,124,300 | Oct 17 | Medusa Distribuzione | false |
| 11 | Bolt | - | - | - | $2,176,547 | 467 | $7,073,495 | Nov 28 | Walt Disney Pictures | false |
| 12 | Pride and Glory | - | - | - | $1,937,573 | 245 | $1,937,573 | Oct 31 | Eagle Pictures | false |
| 13 | Mamma Mia! | - | - | - | $1,904,625 | 400 | $12,919,298 | Oct 3 | United International Pictures | false |
| 14 | The Orphanage | - | - | - | $1,757,959 | 201 | $2,036,551 | Nov 14 | Lucky Red | false |
| 15 | We Can Do That | - | - | - | $1,656,520 | 98 | $2,610,996 | Oct 31 | Warner Bros. | false |
| 16 | The Burning Plain | - | - | - | $1,591,723 | 216 | $1,821,499 | Nov 7 | Medusa Distribuzione | false |
| 17 | Babylon A.D. | - | - | - | $1,531,149 | 254 | $3,374,069 | Oct 24 | Moviemax | false |
| 18 | The Past Is a Foreign Land | - | - | - | $894,268 | 179 | $965,171 | Oct 31 | 01 Distribution | false |
| 19 | Awake | - | - | - | $873,045 | 139 | $924,096 | Nov 14 | Eagle Pictures | false |
| 20 | The Man Who Loves | - | - | - | $871,736 | 184 | $1,997,433 | Oct 24 | Medusa Distribuzione | false |
| 21 | Max Payne | - | - | - | $782,025 | 226 | $1,849,465 | Nov 28 | 20th Century Fox International | false |
| 22 | Just a Father | - | - | - | $742,314 | 214 | $3,065,931 | Nov 28 | Warner Bros. | false |
| 23 | Never Back Down | - | - | - | $734,017 | 169 | $2,084,584 | Nov 28 | Medusa Distribuzione | false |
| 24 | Frontier(s) | - | - | - | $628,995 | 112 | $628,995 | Nov 7 | Moviemax | false |
| 25 | The Class | - | - | - | $564,940 | 108 | $2,223,910 | Oct 10 | Mikado Film | false |
| 26 | Un gioco da ragazze | - | - | - | $529,440 | 173 | $529,440 | Nov 7 | 01 Distribution | false |
| 27 | Galantuomini | - | - | - | $501,516 | 91 | $734,720 | Nov 21 | 01 Distribution | false |
| 28 | Changeling | - | - | - | $483,729 | 299 | $6,693,283 | Nov 14 | Universal Pictures International (UPI) | false |
| 29 | You Don't Mess with the Zohan | - | - | - | $376,178 | 222 | $3,849,845 | Oct 3 | Sony Pictures Releasing | false |
| 30 | The Baader Meinhof Complex | - | - | - | $363,153 | 119 | $363,153 | Oct 31 | BIM Distribuzione | false |
| 31 | No Problem | - | - | - | $353,255 | 423 | $4,837,672 | Oct 10 | Medusa Distribuzione | false |
| 32 | Ti stramo: Ho voglia di un'ultima notte da manuale prima di tre baci sopra il cielo | - | - | - | $271,289 | 105 | $606,209 | Nov 28 | Mikado Film | false |
| 33 | Giovanna's Father | - | - | - | $257,958 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 34 | Mid-August Lunch | - | - | - | $210,800 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 35 | Death Race | - | - | - | $210,166 | 100 | $418,559 | Nov 28 | Universal Pictures International (UPI) | false |
| 36 | Albakiara | - | - | - | $206,477 | 278 | $1,031,340 | Oct 24 | Mikado Film | false |
| 37 | Rachel Getting Married | - | - | - | $156,879 | 20 | $288,409 | Nov 21 | Sony Pictures Releasing | false |
| 38 | Burn After Reading | - | - | - | $149,578 | 421 | $8,734,151 | Sep 19 | Medusa Distribuzione | false |
| 39 | Amore che vieni, amore che vai | - | - | - | $110,544 | 58 | $112,934 | Nov 14 | Istituto Luce | false |
| 40 | Trick or Treaters | - | - | - | $107,006 | 74 | $124,488 | Nov 7 | BIM Distribuzione | false |
| 41 | Lakeview Terrace | - | - | - | $81,030 | 31 | $81,030 | Oct 31 | Sony Pictures Releasing | false |
| 42 | Lecture 21 | - | - | - | $80,975 | 48 | $338,622 | Oct 17 | 01 Distribution | false |
| 43 | Gravehopping | - | - | - | $74,822 | 2 | $43,057 | Jul 4 | - | false |
| 44 | Noah's Ark | - | - | - | $72,787 | 233 | $1,056,897 | Oct 3 | Eagle Pictures | false |
| 45 | Bonneville | - | - | - | $70,749 | 58 | $342,753 | Oct 17 | Teodora Film | false |
| 46 | Palermo Shooting | - | - | - | $66,104 | 40 | $163,763 | Nov 28 | BIM Distribuzione | false |
| 47 | One Day in a Life | - | - | - | $64,158 | 12 | $428,775 | Nov 7 | Ripley's Film | false |
| 48 | Donkey Xote | - | - | - | $55,813 | 69 | $70,295 | Oct 31 | - | false |
| 49 | Control | - | - | - | $54,436 | 10 | $99,924 | Oct 24 | Metacinema | false |
| 50 | Lorna's Silence | - | - | - | $38,728 | 39 | $525,788 | Sep 19 | Lucky Red | false |
| 51 | The Early Bird Catches the Worm | - | - | - | $37,560 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 52 | Pa-ra-da | - | - | - | $23,593 | 52 | $305,344 | Sep 19 | 01 Distribution | false |
| 53 | Miracle at St. Anna | - | - | - | $20,138 | 263 | $1,363,754 | Oct 3 | 01 Distribution | false |
| 54 | Chaos 2002 Re-release | - | - | - | $17,856 | 6 | $42,555 | Mar 21 | 01 Distribution | false |
| 55 | Machan | - | - | - | $17,729 | 48 | $222,580 | Sep 12 | Mikado Film | false |
| 56 | Birdwatchers | - | - | - | $17,456 | 56 | $482,815 | Sep 2 | 01 Distribution | false |
| 57 | Gomorrah | - | - | - | $17,201 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 58 | The Women | - | - | - | $16,150 | 214 | $1,108,539 | Oct 10 | BIM Distribuzione | false |
| 59 | Deep Water 2008 Re-release | - | - | - | $15,374 | 6 | $15,374 | Nov 14 | Fandango | false |
| 60 | The Nightmare Before Christmas 2009 3D Release | - | - | - | $14,301 | 3 | $14,301 | Oct 31 | Walt Disney Pictures | false |
| 61 | Sopra le nuvole | - | - | - | $13,988 | 1 | $13,988 | Nov 22 | - | false |
| 62 | Disaster Movie | - | - | - | $12,537 | 234 | $2,946,110 | Oct 10 | Eagle Pictures | false |
| 63 | Paris | - | - | - | $11,839 | 65 | $695,130 | Sep 26 | BIM Distribuzione | false |
| 64 | Pineapple Express | - | - | - | $11,136 | 11 | $15,084 | Nov 28 | Sony Pictures Releasing | false |
| 65 | The Mist | - | - | - | $10,635 | 207 | $1,902,311 | Oct 10 | Lucky Red | false |
| 66 | Jimmy della collina | - | - | - | $7,600 | 5 | $71,846 | Apr 4 | Aranciafilm | false |
| 67 | Se chiudi gli occhi | - | - | - | $7,246 | 2 | $16,255 | Nov 28 | A.B. Film | false |
| 68 | Rumore bianco | - | - | - | $6,623 | 3 | $11,163 | Nov 28 | - | false |
| 69 | Away from Her | - | - | - | $6,326 | 31 | $136,316 | Feb 15 | Warner Bros. | false |
| 70 | The Santa Clause 2 | - | - | - | $6,268 | 79 | $441,300 | Nov 29 | - | false |
| 71 | The Hurt Locker | - | - | - | $5,528 | 70 | $234,231 | Oct 10 | Warner Bros. | false |
| 72 | The Order | - | - | - | $4,735 | 1 | $5,431 | May 31 | - | false |
| 73 | Righteous Kill | - | - | - | $3,458 | 362 | $4,578,190 | Sep 26 | 01 Distribution | false |
| 74 | Horton Hears a Who! | - | - | - | $3,368 | 463 | $3,958,990 | Apr 18 | 20th Century Fox International | false |
| 75 | Márió, a varázsló | - | - | - | $3,289 | 12 | $238,776 | Nov 28 | L'Altrofilm | false |
| 76 | The Melon Route | - | - | - | $3,246 | 1 | $3,246 | Nov 7 | - | false |
| 77 | Hancock | - | - | - | $3,100 | 678 | $17,819,261 | Sep 12 | Sony Pictures Releasing | false |
| 78 | Into the Wild | - | - | - | $2,485 | 191 | $8,058,998 | Jan 25 | BIM Distribuzione | false |
| 79 | La classe non è acqua Undated Italy Release | - | - | - | $2,196 | 1 | $76,763 | - | Warner Bros. | false |
| 80 | Io non c'entro | - | - | - | $2,105 | 2 | $13,908 | Nov 30 | Independent Films | false |
| 81 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $1,922 | 466 | $7,983,188 | Sep 26 | Universal Pictures International (UPI) | false |
| 82 | Billo - Il Grand Dakhaar | - | - | - | $1,883 | 3 | $26,106 | Sep 19 | - | false |
| 83 | Il pugile e la ballerina | - | - | - | $1,843 | 2 | $1,843 | Nov 7 | - | false |
| 84 | In Bruges | - | - | - | $1,706 | 151 | $772,903 | May 16 | Mikado Film | false |
| 85 | The Night of the Sunflowers | - | - | - | $1,684 | 11 | $67,192 | Jun 13 | Istituto Luce | false |
| 86 | Everyone's Hero | - | - | - | $1,596 | 139 | $483,144 | Sep 12 | Medusa Distribuzione | false |
| 87 | No News from God | - | - | - | $1,575 | 43 | $97,795 | Sep 6 | Lucky Red | false |
| 88 | Il sol dell'avvenire | - | - | - | $1,472 | 2 | $7,105 | Nov 28 | - | false |
| 89 | The Year My Parents Went on Vacation | - | - | - | $1,465 | 27 | $384,887 | Jun 6 | Lucky Red | false |
| 90 | La fabbrica dei tedeschi | - | - | - | $1,429 | 3 | $20,844 | Sep 12 | Istituto Luce | false |
| 91 | Zoè | - | - | - | $1,409 | 1 | $1,409 | Nov 21 | - | false |
| 92 | L'anno mille | - | - | - | $1,140 | 38 | $777,830 | Apr 24 | Mediafilm | false |
| 93 | Le cose in te nascoste | - | - | - | $1,095 | 2 | $1,095 | Nov 28 | A.B. Film | false |
| 94 | The Chronicles of Narnia: Prince Caspian | - | - | - | $1,046 | 601 | $10,800,873 | Aug 14 | Walt Disney Pictures | false |
| 95 | Alvin and the Chipmunks | - | - | - | $499 | 256 | $5,481,266 | Jan 18 | 20th Century Fox International | false |
| 96 | Cover Boy... Last Revolution | - | - | - | $427 | 8 | $147,184 | Mar 21 | Istituto Luce | false |
| 97 | Haïti chérie | - | - | - | $382 | 1 | $7,680 | Sep 26 | - | false |
