| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Departed | - | - | - | $6,871,877 | 422 | $12,237,244 | Oct 27 | Medusa Distribuzione | false |
| 2 | The Devil Wears Prada | - | - | - | $5,415,739 | 420 | $19,304,728 | Oct 13 | 20th Century Fox International | false |
| 3 | Over the Hedge | - | - | - | $4,951,565 | 452 | $9,691,689 | Oct 27 | United International Pictures | false |
| 4 | Anplagghed al cinema | - | - | - | $3,808,464 | 525 | $8,604,198 | Nov 24 | Medusa Distribuzione | false |
| 5 | My Super Ex-Girlfriend | - | - | - | $3,219,807 | 253 | $4,657,653 | Nov 17 | 20th Century Fox International | false |
| 6 | You, Me and Dupree | - | - | - | $3,030,038 | 205 | $3,133,457 | Nov 10 | United International Pictures | false |
| 7 | Marie Antoinette | - | - | - | $2,029,706 | 510 | $3,150,009 | Nov 17 | Sony Pictures Releasing | false |
| 8 | The Unknown Woman | - | - | - | $1,985,565 | 297 | $5,459,456 | Oct 20 | Medusa Distribuzione | false |
| 9 | Children of Men | - | - | - | $1,827,354 | 222 | $2,186,412 | Nov 17 | United International Pictures | false |
| 10 | Babel | - | - | - | $1,812,745 | 270 | $3,372,629 | Oct 27 | 01 Distribution | false |
| 11 | The Lazarus Child | - | - | - | $1,744,619 | 250 | $1,744,619 | Nov 3 | Eagle Pictures | false |
| 12 | Flags of Our Fathers | - | - | - | $1,513,051 | 212 | $1,513,051 | Nov 10 | Warner Bros. | false |
| 13 | The Wind that Shakes the Barley | - | - | - | $1,478,875 | 125 | $2,154,875 | Nov 10 | BIM Distribuzione | false |
| 14 | Trust the Man | - | - | - | $1,073,792 | 110 | $1,076,099 | Nov 3 | Moviemax | false |
| 15 | Our Country | - | - | - | $1,036,192 | 140 | $1,036,309 | Nov 3 | 01 Distribution | false |
| 16 | The Family Friend | - | - | - | $840,890 | 161 | $842,244 | Nov 10 | Medusa Distribuzione | false |
| 17 | World Trade Center | - | - | - | $823,900 | 333 | $7,093,226 | Oct 13 | United International Pictures | false |
| 18 | The Grudge 2 | - | - | - | $820,456 | 251 | $820,614 | Nov 10 | 01 Distribution | false |
| 19 | Quale amore | - | - | - | $665,468 | 123 | $727,282 | Nov 17 | 01 Distribution | false |
| 20 | Fascisti su Marte | - | - | - | $639,049 | 68 | $1,059,366 | Oct 27 | Fandango | false |
| 21 | Ma l'amore... sì! | - | - | - | $611,181 | 192 | $611,181 | Nov 17 | Eagle Pictures | false |
| 22 | Pan's Labyrinth | - | - | - | $556,845 | 151 | $864,082 | Nov 24 | Warner Bros. | false |
| 23 | Scoop | - | - | - | $477,378 | 352 | $5,595,044 | Oct 6 | Medusa Distribuzione | false |
| 24 | Secret Journey | - | - | - | $415,926 | 102 | $418,062 | Nov 3 | Medusa Distribuzione | false |
| 25 | Shortbus | - | - | - | $341,134 | 90 | $674,263 | Nov 24 | BIM Distribuzione | false |
| 26 | Chestnut: Hero of Central Park | - | - | - | $247,327 | 28 | $247,327 | Nov 17 | Mediafilm | false |
| 27 | Any Reason Not to Marry? | - | - | - | $215,383 | 54 | $215,383 | Nov 3 | Warner Bros. | false |
| 28 | Salvatore - Questa è la vita | - | - | - | $191,044 | 54 | $261,281 | Nov 3 | Buena Vista International | false |
| 29 | Azur & Asmar: The Princes' Quest | - | - | - | $91,899 | 130 | $92,622 | Nov 10 | Lucky Red | false |
| 30 | The Lost City | - | - | - | $89,239 | 107 | $89,239 | Nov 17 | Buena Vista International | false |
| 31 | Golden Door | - | - | - | $73,669 | 122 | $3,257,977 | Sep 22 | 01 Distribution | false |
| 32 | Those Happy Days | - | - | - | $59,290 | 124 | $439,050 | Oct 27 | Filmauro | false |
| 33 | N (Io e Napoleone) | - | - | - | $54,698 | 207 | $1,253,693 | Oct 13 | Medusa Distribuzione | false |
| 34 | Little Miss Sunshine | - | - | - | $50,206 | 68 | $2,039,673 | Sep 22 | 20th Century Fox International | false |
| 35 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $48,280 | 877 | $25,212,003 | Sep 13 | Buena Vista International | false |
| 36 | Talladega Nights: The Ballad of Ricky Bobby | - | - | - | $42,353 | 30 | $42,353 | Nov 3 | Sony Pictures Releasing | false |
