| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Nomadland | - | - | - | $1,623,488 | 195 | $2,356,666 | Apr 29 | Walt Disney Pictures | false |
| 2 | Cruella | - | - | - | $641,911 | 569 | $2,878,387 | May 26 | Walt Disney Studios Motion Pictures | false |
| 3 | The Bad Poet | - | - | - | $487,991 | 322 | $890,592 | May 20 | 01 Distribution | false |
| 4 | Rifkin's Festival | - | - | - | $403,383 | 205 | $740,455 | May 6 | - | false |
| 5 | Another Round | - | - | - | $378,079 | 242 | $815,062 | May 20 | Medusa Distribuzione | false |
| 6 | The Father | - | - | - | $348,307 | 338 | $1,447,821 | May 27 | BIM Distribuzione | false |
| 7 | The Unholy | - | - | - | $250,568 | 183 | $313,670 | May 20 | Sony Pictures Releasing | false |
| 8 | Minari | - | - | - | $235,689 | 74 | $308,013 | Apr 22 | - | false |
| 9 | 100% Wolf | - | - | - | $218,495 | 193 | $443,476 | May 20 | BIM Distribuzione | false |
| 10 | Adventures Italian Style | - | - | - | $61,897 | 99 | $78,410 | Apr 26 | Genoma Films | false |
| 11 | Freaky | - | - | - | $53,769 | 173 | $121,454 | May 27 | Universal Pictures International (UPI) | false |
| 12 | Corpus Christi | - | - | - | $46,418 | 36 | $67,167 | May 6 | Wanted | false |
| 13 | The Human Voice | - | - | - | $42,498 | 83 | $49,913 | May 13 | Warner Bros. | false |
| 14 | Tom & Jerry | - | - | - | $35,837 | 55 | $41,235 | May 13 | Warner Bros. | false |
| 15 | God, You're Such a Prick | - | - | - | $31,782 | 145 | $31,782 | May 20 | BIM Distribuzione | false |
| 16 | Wonder Woman 1984 | - | - | - | $31,407 | 43 | $38,160 | May 13 | Warner Bros. | false |
| 17 | Gloria Mundi | - | - | - | $30,356 | 21 | $34,296 | May 13 | Parthenos | false |
| 18 | Hidden Away | - | - | - | $29,004 | 316 | $1,031,096 | Mar 4 | 01 Distribution | false |
| 19 | Dear Diary | - | - | - | $25,326 | 21 | $104,450 | Oct 15 | Fondazione Cineteca di Bologna | false |
| 20 | Two of Us | - | - | - | $24,860 | 22 | $62,797 | May 6 | Teodora Film | false |
| 21 | Bad Luck Banging or Loony Porn | - | - | - | $24,167 | 18 | $24,167 | Apr 29 | Lucky Red | false |
| 22 | Misbehaviour | - | - | - | $23,866 | 67 | $42,836 | May 13 | BIM Distribuzione | false |
| 23 | In the Mood for Love 2020 Re-release | - | - | - | $21,489 | 23 | $28,363 | Apr 29 | Tucker Film | false |
| 24 | Morrison | - | - | - | $18,728 | 142 | $29,519 | May 20 | Universal Pictures International (UPI) | false |
| 25 | In the Mood for Love 2021 Re-release | - | - | - | $18,663 | 29 | $188,856 | Apr 28 | Tucker Film | false |
| 26 | Arab Blues | - | - | - | $17,136 | 172 | $598,007 | Apr 29 | BIM Distribuzione | false |
| 27 | Chungking Express 2021 Re-release | - | - | - | $12,666 | 15 | $47,219 | May 20 | Tucker Film | false |
| 28 | The Predators | - | - | - | $11,460 | 357 | $206,589 | Oct 22 | 01 Distribution | false |
| 29 | Trash | - | - | - | $10,740 | 324 | $299,700 | Oct 16 | BIM Distribuzione | false |
| 30 | Fortuna | - | - | - | $8,987 | 32 | $14,950 | May 27 | I Wonder Pictures | false |
| 31 | The Little Things | - | - | - | $8,758 | 14 | $34,800 | May 6 | Warner Bros. | false |
| 32 | Lei mi parla ancora | - | - | - | $6,941 | 15 | $8,507 | Apr 26 | - | false |
| 33 | New Order | - | - | - | $6,687 | 7 | $11,861 | Apr 26 | I Wonder Pictures | false |
| 34 | Persian Lessons | - | - | - | $6,206 | 10 | $12,171 | Apr 26 | - | false |
| 35 | Babyteeth | - | - | - | $5,792 | 18 | $5,792 | May 13 | Movies Inspired | false |
| 36 | Nomad: In the Footsteps of Bruce Chatwin | - | - | - | $5,089 | 28 | $90,654 | Oct 19 | Wanted | false |
| 37 | Rassegna Cinematografica | - | - | - | $4,976 | 61 | $1,486,466 | Sep 8 | - | false |
| 38 | About Endlessness | - | - | - | $3,397 | 15 | $9,743 | May 27 | Wanted | false |
| 39 | Stitches 2021 Re-release | - | - | - | $3,193 | 10 | $3,193 | May 13 | - | false |
| 40 | Alps 2020 Re-release | - | - | - | $2,970 | 1 | $31,137 | - | Phoenix Productions (II) | false |
| 41 | Diary of Love | - | - | - | $2,625 | 22 | $13,161 | May 27 | Europictures | false |
| 42 | Collective | - | - | - | $1,892 | 5 | $3,219 | Apr 29 | I Wonder Pictures | false |
| 43 | Genitori vs Influencer | - | - | - | $1,356 | 3 | $1,356 | Apr 29 | - | false |
| 44 | Thunder Road | - | - | - | $1,297 | 4 | $1,760 | Apr 29 | Wanted | false |
| 45 | Everything's Gonna Be Alright | - | - | - | $1,219 | 297 | $84,577 | Oct 24 | Universal Pictures International (UPI) | false |
| 46 | Gunda | - | - | - | $1,180 | 6 | $7,198 | May 13 | I Wonder Pictures | false |
| 47 | The Ties | - | - | - | $899 | 398 | $952,623 | Sep 30 | 01 Distribution | false |
| 48 | Il buco in testa | - | - | - | $806 | 1 | $806 | May 14 | - | false |
| 49 | The Specials 2021 New-release | - | - | - | $799 | 2 | $7,355 | May 4 | Lucky Red | false |
| 50 | Harry Potter and the Goblet of Fire 2021 Re-release | - | - | - | $640 | 1 | $215,355 | - | Warner Bros. | false |
| 51 | The Macaluso Sisters | - | - | - | $619 | 123 | $528,744 | Sep 10 | Teodora Film | false |
| 52 | The Birds 2021 Re-release | - | - | - | $601 | 1 | $20,556 | - | Fondazione Cineteca di Bologna | false |
| 53 | Crescendo | - | - | - | $587 | 38 | $97,861 | Aug 27 | Satine Film | false |
| 54 | Alida | - | - | - | $550 | 1 | $550 | May 14 | - | false |
| 55 | Vivere | - | - | - | $540 | 281 | $64,447 | Sep 26 | 01 Distribution | false |
| 56 | Sadness Has a Light Sleep | - | - | - | $529 | 1 | $529 | May 13 | Nomad Entertainment | false |
| 57 | On a Magical Night | - | - | - | $397 | 37 | $130,321 | Feb 20 | Officine UBU | false |
| 58 | Cinematti - Una storia folle | - | - | - | $363 | 1 | $363 | May 15 | MovieDay | false |
| 59 | The Cat Rescuers Original Release | - | - | - | $330 | 1 | $330 | May 13 | Wanted | false |
| 60 | Undine | - | - | - | $323 | 51 | $145,702 | Sep 24 | Europictures | false |
| 61 | Sorry We Missed You | - | - | - | $293 | 101 | $1,842,981 | Jan 2 | Lucky Red | false |
| 62 | Delete History | - | - | - | $285 | 50 | $40,828 | Oct 15 | Officine UBU | false |
| 63 | Dogtooth 2020 Re-release | - | - | - | $284 | 136 | $256,031 | Aug 27 | Lucky Red | false |
| 64 | Whatever Happened to My Revolution | - | - | - | $271 | 18 | $37,535 | Aug 27 | Wanted | false |
| 65 | Palm Springs | - | - | - | $247 | 265 | $119,035 | Oct 22 | I Wonder Pictures | false |
