| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | A Quiet Place Part II | - | - | - | $57,088,948 | 3,744 | $160,072,261 | May 28 | Paramount Pictures | false |
| 2 | Cruella | - | - | - | $26,532,683 | 3,922 | $86,103,234 | May 28 | Walt Disney Studios Motion Pictures | false |
| 3 | Wrath of Man | - | - | - | $22,737,520 | 3,007 | $27,466,489 | May 7 | United Artists Releasing | false |
| 4 | Spiral | - | - | - | $20,205,126 | 2,991 | $23,216,862 | May 14 | Lionsgate | false |
| 5 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $17,271,962 | 2,087 | $49,505,008 | Apr 23 | FUNimation Entertainment | false |
| 6 | Mortal Kombat | - | - | - | $12,551,971 | 3,114 | $42,326,031 | Apr 23 | Warner Bros. | false |
| 7 | Raya and the Last Dragon | - | - | - | $11,101,012 | 2,375 | $54,723,032 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 8 | Godzilla vs. Kong | - | - | - | $9,593,076 | 3,084 | $100,916,094 | Mar 31 | Warner Bros. | false |
| 9 | Those Who Wish Me Dead | - | - | - | $6,154,173 | 3,379 | $7,407,200 | May 14 | Warner Bros. | false |
| 10 | Separation | - | - | - | $3,816,462 | 1,911 | $4,509,143 | Apr 30 | Open Road Films (II) | false |
| 11 | Nobody | - | - | - | $3,530,720 | 2,567 | $27,568,035 | Mar 26 | Universal Pictures | false |
| 12 | The Unholy | - | - | - | $3,069,694 | 2,057 | $15,532,137 | Apr 2 | Screen Gems | false |
| 13 | Here Today | - | - | - | $2,696,311 | 1,230 | $2,807,494 | May 7 | Stage 6 Films | false |
| 14 | Finding You | - | - | - | $2,496,337 | 1,447 | $2,753,985 | May 14 | Roadside Attractions | false |
| 15 | Tom & Jerry | - | - | - | $1,972,648 | 2,563 | $46,536,687 | Feb 26 | Warner Bros. | false |
| 16 | Dream Horse | - | - | - | $1,918,625 | 1,284 | $2,913,328 | May 21 | Bleecker Street Media | false |
| 17 | Profile | - | - | - | $1,735,090 | 2,104 | $1,744,740 | May 14 | Focus Features | false |
| 18 | Scott Pilgrim vs. the World 10th Anniversary (2021 Re-release) | - | - | - | $913,730 | 448 | $1,867,625 | - | Universal Pictures | false |
| 19 | The Croods: A New Age | - | - | - | $864,660 | 2,211 | $58,568,815 | Nov 25 | Universal Pictures | false |
| 20 | Scoob! | - | - | - | $850,000 | - | $2,188,425 | May 21 | Warner Bros. | false |
| 21 | Four Good Days | - | - | - | $738,045 | 489 | $837,849 | Apr 30 | Vertical Entertainment | false |
| 22 | Together Together | - | - | - | $617,750 | 665 | $1,437,938 | Apr 23 | Bleecker Street Media | false |
| 23 | The Girl Who Believes in Miracles | - | - | - | $523,390 | 1,012 | $3,163,362 | Apr 2 | Atlas Distribution Company | false |
| 24 | Long Weekend | - | - | - | $488,212 | 821 | $1,018,532 | Mar 12 | Stage 6 Films | false |
| 25 | World War Z 2021 Re-release | - | - | - | $448,000 | 80 | $448,000 | May 28 | Paramount Pictures | true |
| 26 | The Courier | - | - | - | $443,419 | 1,641 | $6,613,432 | Mar 19 | Roadside Attractions | false |
| 27 | Top Gun 2021 Re-release | - | - | - | $408,937 | 153 | $457,577 | May 14 | Paramount Pictures | false |
| 28 | The Father | - | - | - | $324,739 | 933 | $2,122,771 | Feb 26 | Sony Pictures Classics | false |
| 29 | Minari | - | - | - | $315,164 | 912 | $3,110,580 | Feb 12 | A24 | false |
| 30 | The Water Man | - | - | - | $294,748 | 311 | $383,234 | May 7 | RLJ Entertainment | false |
| 31 | Final Account | - | - | - | $283,995 | 308 | $308,976 | May 21 | Focus Features | false |
| 32 | New Order | - | - | - | $274,616 | 236 | $303,556 | May 21 | Neon | false |
| 33 | The Dry | - | - | - | $241,460 | 186 | $364,237 | May 21 | IFC Films | false |
| 34 | The Truffle Hunters | - | - | - | $204,244 | 105 | $521,202 | Mar 5 | Sony Pictures Classics | false |
| 35 | Limbo | - | - | - | $193,365 | 213 | $224,405 | Apr 30 | Focus Features | false |
| 36 | The Resort | - | - | - | $165,257 | 114 | $191,996 | Apr 30 | Vertical Entertainment | false |
| 37 | Cliff Walkers | - | - | - | $136,749 | 65 | $152,972 | Apr 30 | CMC Pictures | false |
| 38 | The Djinn | - | - | - | $122,052 | 44 | $124,772 | May 14 | IFC Films | false |
| 39 | Walking with Herb | - | - | - | $120,226 | 507 | $120,226 | May 7 | Fathom Events | false |
| 40 | Voyagers | - | - | - | $104,116 | 1,996 | $3,149,935 | Apr 9 | Lionsgate | false |
| 41 | Chaos Walking | - | - | - | $92,490 | 2,132 | $13,287,908 | Mar 5 | Lionsgate | false |
| 42 | The Paper Tigers | - | - | - | $90,833 | 65 | $112,691 | May 7 | Well Go USA Entertainment | false |
| 43 | The War with Grandpa | - | - | - | $86,126 | 2,365 | $21,277,892 | Oct 9 | 101 Studios | false |
| 44 | My Love | - | - | - | $85,187 | 25 | $86,252 | May 7 | CMC Pictures | false |
| 45 | Mission Stories | - | - | - | $83,437 | 44 | $87,059 | May 7 | Excel Entertainment | false |
| 46 | French Exit | - | - | - | $67,557 | 493 | $741,895 | Feb 12 | Sony Pictures Classics | false |
| 47 | The Killing of Two Lovers | - | - | - | $66,068 | 36 | $71,162 | May 14 | Neon | false |
| 48 | Wrong Turn | - | - | - | $60,616 | 259 | $1,251,184 | Jan 26 | Saban Films | false |
| 49 | In the Earth | - | - | - | $50,369 | 571 | $1,113,723 | Apr 16 | Neon | false |
| 50 | Riders of Justice | - | - | - | $47,460 | 18 | $77,115 | May 14 | Magnolia Pictures | false |
| 51 | Gunda | - | - | - | $38,171 | 35 | $115,691 | Apr 16 | Neon | false |
| 52 | The Swimming Pool 2021 Re-release | - | - | - | $37,678 | 10 | $211,467 | May 14 | Rialto Distribution | false |
| 53 | Shiva Baby | - | - | - | $36,823 | 27 | $159,294 | Apr 2 | Utopia | false |
| 54 | The Human Factor | - | - | - | $35,570 | 90 | $36,693 | May 7 | Sony Pictures Classics | false |
| 55 | Wonder Woman 1984 | - | - | - | $35,342 | 2,218 | $46,801,036 | Dec 25 | Warner Bros. | false |
| 56 | Mainstream | - | - | - | $34,673 | 76 | $35,696 | May 7 | IFC Films | false |
| 57 | About Endlessness | - | - | - | $33,360 | 17 | $51,386 | Apr 30 | Magnolia Pictures | false |
| 58 | Monster Hunter | - | - | - | $27,635 | 1,817 | $15,162,470 | Dec 18 | Screen Gems | false |
| 59 | Judas and the Black Messiah | - | - | - | $19,525 | 1,906 | $5,478,009 | Feb 12 | Warner Bros. | false |
| 60 | Equal Standard | - | - | - | $15,938 | 25 | $15,938 | May 7 | Mutiny Pictures | false |
| 61 | The Little Things | - | - | - | $15,187 | 2,206 | $15,342,746 | Jan 29 | Warner Bros. | false |
| 62 | The Perfect Candidate | - | - | - | $13,702 | 17 | $30,134 | May 14 | Music Box Films | false |
| 63 | 100% Wolf | - | - | - | $11,283 | 124 | $658,764 | Oct 9 | Viva Pictures | false |
| 64 | 2021 Oscar Nominated Short Films: Live Action | - | - | - | $10,157 | 184 | $443,050 | Apr 2 | Magnolia Pictures | false |
| 65 | State Funeral | - | - | - | $9,913 | 2 | $11,342 | May 7 | MUBI | false |
| 66 | Held | - | - | - | $9,554 | 129 | $142,817 | Apr 9 | Magnolia Pictures | false |
| 67 | Dutch | - | - | - | $8,543 | 202 | $404,371 | Mar 12 | Faith Media Distribution | false |
| 68 | There Is No Evil | - | - | - | $7,936 | 7 | $8,063 | May 14 | Kino Lorber | false |
| 69 | Endless Rain | - | - | - | $6,541 | 14 | $7,334 | Apr 30 | Sony Pictures Releasing | false |
| 70 | Ghost Master | - | - | - | $5,943 | 2 | $6,136 | May 14 | Indican Pictures | false |
| 71 | Six Minutes to Midnight | - | - | - | $5,328 | 145 | $132,500 | Mar 26 | IFC Films | false |
| 72 | Paper Spiders | - | - | - | $2,992 | 17 | $2,992 | May 7 | Entertainment Squad | false |
| 73 | Psycho Goreman | - | - | - | $2,402 | 70 | $95,182 | Jan 22 | RLJ Entertainment | false |
| 74 | Lamb of God: The Concert Film | - | - | - | $1,644 | 138 | $744,813 | Mar 12 | Excel Entertainment | false |
| 75 | The Unthinkable | - | - | - | $974 | 3 | $974 | May 7 | Magnolia Pictures | false |
| 76 | My Zoe | - | - | - | $852 | 237 | $52,733 | Feb 26 | Blue Fox Entertainment | false |
| 77 | Monday | - | - | - | $726 | 54 | $30,932 | Apr 16 | IFC Films | false |
| 78 | The Boonies | - | - | - | $588 | 2 | $6,887 | Mar 31 | Indican Pictures | false |
| 79 | Bill Traylor: Chasing Ghosts | - | - | - | $361 | 2 | $4,504 | Apr 16 | Kino Lorber | false |
| 80 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $344 | 2 | $12,486 | Feb 12 | Indican Pictures | false |
| 81 | Blood Brothers: Civil War | - | - | - | $294 | 2 | $5,191 | Apr 2 | Indican Pictures | false |
| 82 | Funhouse | - | - | - | $288 | 3 | $507 | May 28 | Magnet Releasing | false |
| 83 | The World to Come | - | - | - | $228 | 277 | $116,143 | Feb 12 | Bleecker Street Media | false |
