| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avengers: Infinity War | - | - | - | $33,690,560 | - | $60,058,771 | Apr 27 | Walt Disney Pictures | false |
| 2 | Overboard | - | - | - | $23,691,032 | 3,000 | $26,170,477 | May 10 | Videocine | false |
| 3 | Deadpool 2 | - | - | - | $17,337,714 | 3,013 | $21,699,145 | May 18 | 20th Century Fox International | false |
| 4 | The Strangers: Prey at Night | - | - | - | $1,230,386 | - | $1,230,386 | May 4 | Diamond Films | false |
| 5 | Paul, Apostle of Christ | - | - | - | $897,117 | - | $897,117 | May 4 | Cinépolis Distribución | false |
| 6 | Rampage | - | - | - | $675,858 | - | $12,800,000 | Apr 13 | Warner Bros. | false |
| 7 | Blockers | - | - | - | $596,040 | 334 | $1,017,107 | May 25 | Universal Pictures International (UPI) | false |
| 8 | Isle of Dogs | - | - | - | $581,372 | 85 | $954,292 | May 4 | 20th Century Fox International | false |
| 9 | Truth or Dare | - | - | - | $471,327 | 682 | $3,077,198 | Apr 20 | Universal Pictures International (UPI) | false |
| 10 | Gnome Alone | - | - | - | $458,649 | - | $1,017,401 | Apr 20 | Latam Pictures | false |
| 11 | Nothing to Lose | - | - | - | $410,131 | - | $498,677 | May 11 | Cinépolis Distribución | false |
| 12 | 24 Hours to Live | - | - | - | $385,545 | 1 | $792,525 | May 4 | - | false |
| 13 | Book Club | - | - | - | $337,521 | - | $2,528,585 | Jun 1 | Zima Entertainment | false |
| 14 | Midnight Sun | - | - | - | $305,789 | - | $390,262 | May 25 | Sun Distribution | false |
| 15 | A Quiet Place | - | - | - | $296,877 | 750 | $7,602,358 | Apr 6 | Paramount Pictures International | false |
| 16 | Love, Simon | - | - | - | $198,980 | 778 | $2,656,477 | Apr 13 | 20th Century Fox International | false |
| 17 | The Fixies: Top Secret | - | - | - | $197,508 | - | $197,508 | May 18 | Corazón Films | false |
| 18 | The Ritual | - | - | - | $170,916 | - | $482,746 | May 11 | Imagem Filmes | false |
| 19 | Champions | - | - | - | $105,248 | 190 | $453,168 | May 18 | Universal Pictures International (UPI) | false |
| 20 | Tully | - | - | - | $97,813 | - | $118,405 | May 11 | Diamond Films | false |
| 21 | Slumber | - | - | - | $92,665 | - | $108,109 | May 11 | Amarok Films | false |
| 22 | El ángel en el reloj | - | - | - | $88,009 | - | $88,009 | May 25 | Cinépolis Distribución | false |
| 23 | You Were Never Really Here | - | - | - | $85,962 | - | $85,962 | May 25 | Cine Canibal | false |
| 24 | Gringo | - | - | - | $73,674 | - | $145,000 | May 18 | Sun Distribution | false |
| 25 | 12 Strong | - | - | - | $70,198 | 165 | $499,406 | Mar 9 | Sun Distribution | false |
| 26 | Peter Rabbit | - | - | - | $66,854 | 1,718 | $4,456,983 | Mar 16 | Sony Pictures Releasing | false |
| 27 | Sherlock Gnomes | - | - | - | $42,342 | 743 | $2,651,361 | Mar 30 | Paramount Pictures International | false |
| 28 | 7 Days in Entebbe | - | - | - | $39,097 | 119 | $342,278 | Apr 13 | Sun Distribution | false |
| 29 | Lady Bird | - | - | - | $34,542 | 75 | $441,013 | Feb 16 | Universal Pictures International (UPI) | false |
| 30 | Black Panther | - | - | - | $11,881 | - | $28,322,788 | Feb 16 | Walt Disney Pictures | false |
| 31 | A Wrinkle in Time | - | - | - | $10,616 | - | $2,371,483 | Mar 29 | Walt Disney Pictures | false |
| 32 | Phantom Thread | - | - | - | $10,609 | 56 | $386,151 | Feb 23 | Universal Pictures International (UPI) | false |
| 33 | Earth: One Amazing Day | - | - | - | $8,600 | 11 | $8,600 | May 4 | Universal Pictures International (UPI) | false |
| 34 | Coco | - | - | - | $8,215 | - | $57,860,947 | Oct 27 | Walt Disney Pictures | false |
| 35 | Based on a True Story | - | - | - | $4,482 | 145 | $329,823 | Mar 16 | - | false |
| 36 | Game Night | - | - | - | $3,115 | - | $1,403,115 | Apr 6 | Warner Bros. | false |
| 37 | Darkest Hour | - | - | - | $2,029 | 95 | $621,821 | Jan 19 | Universal Pictures International (UPI) | false |
| 38 | Mary Magdalene | - | - | - | $1,506 | 222 | $616,645 | Mar 23 | Universal Pictures International (UPI) | false |
| 39 | Human Flow | - | - | - | $1,419 | 7 | $7,871 | Mar 22 | - | false |
| 40 | Pacific Rim: Uprising | - | - | - | $1,020 | 807 | $11,821,225 | Mar 23 | Universal Pictures International (UPI) | false |
