| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avengers: Infinity War | - | - | - | $10,604,477 | 976 | $22,837,545 | Apr 25 | Walt Disney Pictures | false |
| 2 | Deadpool 2 | - | - | - | $5,555,929 | 709 | $8,652,468 | May 16 | 20th Century Fox International | false |
| 3 | Loro 2 | - | - | - | $2,819,948 | 543 | $2,985,436 | May 10 | Universal Pictures International (UPI) | false |
| 4 | Loro 1 | - | - | - | $2,665,208 | 539 | $4,740,179 | Apr 26 | Universal Pictures International (UPI) | false |
| 5 | Solo: A Star Wars Story | - | - | - | $2,290,148 | 837 | $5,255,534 | May 23 | Walt Disney Pictures | false |
| 6 | Dogman | - | - | - | $1,955,963 | 419 | $2,968,706 | May 17 | 01 Distribution | false |
| 7 | Arrivano i prof | - | - | - | $1,877,342 | 430 | $2,355,619 | May 3 | 01 Distribution | false |
| 8 | Loving Pablo | - | - | - | $1,498,038 | 750 | $4,023,182 | Apr 19 | Notorious Pictures | false |
| 9 | Show Dogs | - | - | - | $1,442,857 | 386 | $1,681,987 | May 10 | Eagle Pictures | false |
| 10 | Game Night | - | - | - | $877,569 | 288 | $1,076,185 | May 3 | Warner Bros. | false |
| 11 | Isle of Dogs | - | - | - | $659,829 | 280 | $949,142 | May 1 | 20th Century Fox International | false |
| 12 | Tonno spiaggiato | - | - | - | $443,769 | 318 | $443,769 | May 10 | - | false |
| 13 | Rampage | - | - | - | $259,914 | 430 | $3,300,000 | Apr 12 | Warner Bros. | false |
| 14 | The House by the Sea | - | - | - | $246,522 | 53 | $574,986 | Apr 12 | Parthenos | false |
| 15 | Sherlock Gnomes | - | - | - | $244,434 | 351 | $920,901 | Apr 12 | Paramount Pictures International | false |
| 16 | Tu mi nascondi qualcosa | - | - | - | $231,910 | 228 | $527,951 | Apr 26 | Eagle Pictures | false |
| 17 | The Full House | - | - | - | $220,071 | 208 | $237,750 | May 17 | Notorious Pictures | false |
| 18 | Ready Player One | - | - | - | $217,282 | 577 | $6,100,000 | Mar 28 | Warner Bros. | false |
| 19 | Lost in Paris | - | - | - | $216,091 | 63 | $413,654 | May 17 | Academy 2 | false |
| 20 | What Will People Say | - | - | - | $215,441 | 61 | $215,441 | May 3 | Lucky Red | false |
| 21 | You Were Never Really Here | - | - | - | $204,730 | 110 | $241,732 | May 3 | Europictures | false |
| 22 | Hotel Gagarin | - | - | - | $193,302 | 165 | $434,029 | May 24 | Altre Storie | false |
| 23 | La Melodie | - | - | - | $178,829 | 50 | $330,955 | Apr 26 | Officine UBU | false |
| 24 | Wonders of the Sea | - | - | - | $178,635 | 251 | $178,635 | May 17 | M2 Pictures | false |
| 25 | Si muore tutti democristiani | - | - | - | $164,524 | 159 | $164,524 | May 10 | 01 Distribution | false |
| 26 | Nobili bugie | - | - | - | $147,505 | 33 | $373,721 | May 24 | Genoma Films | false |
| 27 | Io sono Tempesta | - | - | - | $139,898 | 656 | $1,993,225 | Apr 12 | 01 Distribution | false |
| 28 | Wajib | - | - | - | $130,832 | 31 | $191,398 | Apr 26 | Satine Film | false |
| 29 | Let the Sunshine In | - | - | - | $73,729 | 79 | $294,348 | Apr 19 | - | false |
| 30 | Blockers | - | - | - | $70,851 | 105 | $70,851 | May 17 | Universal Pictures International (UPI) | false |
| 31 | Den of Thieves | - | - | - | $65,899 | 367 | $2,714,645 | Apr 5 | Lucky Red | false |
| 32 | Peter Rabbit | - | - | - | $62,807 | 477 | $3,202,682 | Mar 22 | Sony Pictures Releasing | false |
| 33 | I, Tonya | - | - | - | $56,393 | 287 | $2,109,793 | Mar 29 | Lucky Red | false |
| 34 | Eva | - | - | - | $51,385 | 48 | $51,385 | May 3 | Teodora Film | false |
| 35 | Jeune Femme | - | - | - | $49,559 | 37 | $67,854 | May 24 | Parthenos | false |
| 36 | Mektoub, My Love: Canto Uno | - | - | - | $35,949 | 73 | $35,949 | May 24 | - | false |
| 37 | Call Me by Your Name | - | - | - | $33,114 | 582 | $4,157,606 | Jan 25 | Sony Pictures Releasing | false |
| 38 | Darkest Hour | - | - | - | $18,857 | 385 | $5,157,633 | Jan 18 | Universal Pictures International (UPI) | false |
| 39 | Bob & Marys | - | - | - | $17,374 | 186 | $273,055 | Apr 5 | Videa | false |
| 40 | A Quiet Place | - | - | - | $8,168 | 308 | $1,339,341 | Apr 5 | Paramount Pictures International | false |
| 41 | Coco | - | - | - | $6,889 | 692 | $13,019,466 | Dec 28 | Walt Disney Pictures | false |
| 42 | Based on a True Story | - | - | - | $6,139 | 214 | $596,189 | Mar 1 | Andrea Leone Films | false |
| 43 | Wonder | - | - | - | $560 | 500 | $14,084,960 | Dec 21 | 01 Distribution | false |
| 44 | Black Panther | - | - | - | $152 | 487 | $8,953,417 | Feb 14 | Walt Disney Pictures | false |
| 45 | A Wrinkle in Time | - | - | - | $126 | 61 | $171,758 | Mar 29 | Walt Disney Pictures | false |
| 46 | No Date, No Signature | - | - | - | $1 | - | $24,606 | May 10 | - | false |
