| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Captain America: Civil War | - | - | - | $971,858 | 138 | $2,132,347 | Apr 29 | Ster-Kinekor Pictures | false |
| 2 | The Angry Birds Movie | - | - | - | $709,369 | 123 | $607,180 | May 13 | Sony Pictures Releasing | false |
| 3 | X-Men: Apocalypse | - | - | - | $599,722 | 132 | $1,039,752 | May 20 | Times Media Films | false |
| 4 | Mother's Day | - | - | - | $387,223 | 74 | $413,987 | May 6 | Times Media Films | false |
| 5 | The Jungle Book | - | - | - | $336,326 | 125 | $2,126,980 | Apr 15 | Ster-Kinekor Pictures | false |
| 6 | Neighbors 2: Sorority Rising | - | - | - | $285,596 | 54 | $426,346 | May 6 | Universal Pictures International (UPI) | false |
| 7 | The Perfect Match | - | - | - | $194,112 | 46 | $440,822 | May 13 | NuMetro Distribution | false |
| 8 | Alice Through the Looking Glass | - | - | - | $147,387 | 118 | $476,151 | May 27 | Ster-Kinekor Pictures | false |
| 9 | The Huntsman: Winter's War | - | - | - | $130,763 | 99 | $783,809 | Apr 22 | United International Pictures | false |
| 10 | Barbershop: The Next Cut | - | - | - | $100,095 | 52 | $330,500 | Apr 22 | Times Media Films | false |
| 11 | Miracles from Heaven | - | - | - | $85,829 | 36 | $93,805 | May 6 | Sony Pictures Releasing | false |
| 12 | The Boss | - | - | - | $67,275 | 60 | $283,172 | May 27 | Universal Pictures International (UPI) | false |
| 13 | Ratchet & Clank | - | - | - | $63,746 | 61 | $163,657 | Apr 29 | Times Media Films | false |
| 14 | Uitvlucht | - | - | - | $63,298 | 37 | $85,646 | May 13 | Ster-Kinekor Pictures | false |
| 15 | The Take | - | - | - | $46,403 | 68 | $129,043 | May 27 | - | false |
| 16 | The Man Who Knew Infinity | - | - | - | $29,735 | 11 | $94,582 | May 20 | Times Media Films | false |
| 17 | Queen of the Desert | - | - | - | $21,531 | 15 | $37,163 | Apr 29 | Ster-Kinekor Pictures | false |
| 18 | Regression | - | - | - | $19,020 | 21 | $19,020 | May 6 | Ster-Kinekor Pictures | false |
| 19 | Before I Wake | - | - | - | $18,807 | 21 | $18,807 | May 20 | Ster-Kinekor Pictures | false |
| 20 | Mignon Mossie van Wyk | - | - | - | $18,532 | 27 | $18,532 | May 6 | United International Pictures | false |
| 21 | Sing Street | - | - | - | $15,775 | 14 | $28,091 | May 20 | Ster-Kinekor Pictures | false |
| 22 | Whiskey Tango Foxtrot | - | - | - | $15,415 | 12 | $15,415 | May 13 | United International Pictures | false |
| 23 | Free State | - | - | - | $13,827 | 27 | $34,785 | Apr 29 | Times Media Films | false |
| 24 | Criminal | - | - | - | $13,207 | 36 | $123,374 | Apr 15 | - | false |
| 25 | Jane Got a Gun | - | - | - | $7,704 | 7 | $11,052 | Apr 29 | Times Media Films | false |
| 26 | Demolition | - | - | - | $7,334 | 26 | $51,186 | Apr 22 | Ster-Kinekor Pictures | false |
| 27 | Irrational Man | - | - | - | $5,788 | 11 | $25,879 | Apr 22 | Ster-Kinekor Pictures | false |
| 28 | Verskietende Ster | - | - | - | $5,156 | 34 | $35,384 | Apr 22 | - | false |
| 29 | Eye in the Sky | - | - | - | $1,908 | 31 | $98,191 | Mar 11 | Times Media Films | false |
| 30 | Macbeth | - | - | - | $1,277 | 12 | $27,781 | Apr 8 | - | false |
| 31 | The Road Within | - | - | - | $1,135 | 4 | $2,212 | May 27 | Times Media Films | false |
