| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $160,648 | 12 | $407,666 | May 20 | Walt Disney Pictures | false |
| 2 | Rio | - | - | - | $102,276 | 14 | $345,697 | Apr 14 | 20th Century Fox International | false |
| 3 | The White Lions | - | - | - | $70,512 | 10 | $123,275 | Apr 28 | - | false |
| 4 | Thor | - | - | - | $52,488 | 5 | $72,757 | Apr 28 | United International Pictures | false |
| 5 | The Hangover Part II | - | - | - | $38,823 | 7 | $338,231 | May 26 | Warner Bros. | false |
| 6 | Fast Five | - | - | - | $37,840 | 4 | $42,975 | May 5 | United International Pictures | false |
| 7 | Red Riding Hood | - | - | - | $31,040 | 7 | $51,040 | Apr 28 | Warner Bros. | false |
| 8 | Unknown | - | - | - | $22,237 | 7 | $48,590 | Apr 21 | Warner Bros. | false |
| 9 | Just Go with It | - | - | - | $18,150 | 8 | $83,774 | Apr 7 | Sony Pictures Releasing | false |
| 10 | Water for Elephants | - | - | - | $14,460 | 5 | $33,860 | Apr 21 | 20th Century Fox International | false |
| 11 | The Rite | - | - | - | $8,762 | 7 | $48,282 | Apr 14 | Warner Bros. | false |
| 12 | Source Code | - | - | - | $5,791 | 4 | $25,649 | Apr 7 | - | false |
| 13 | Limitless | - | - | - | $4,542 | 4 | $65,380 | Mar 24 | - | false |
| 14 | Zduhac Means Adventure | - | - | - | $3,551 | 4 | $45,424 | Apr 7 | - | false |
| 15 | Hop | - | - | - | $2,759 | 5 | $17,697 | Mar 31 | Walt Disney Pictures | false |
| 16 | The King's Speech | - | - | - | $2,552 | 4 | $86,214 | Mar 3 | - | false |
| 17 | Rango | - | - | - | $2,537 | 5 | $52,095 | Mar 17 | United International Pictures | false |
| 18 | Potiche | - | - | - | $2,078 | 1 | $18,644 | Apr 21 | - | false |
| 19 | Black Swan | - | - | - | $1,995 | 5 | $103,749 | Mar 10 | 20th Century Fox International | false |
| 20 | Hereafter | - | - | - | $1,927 | 4 | $29,628 | Mar 31 | Warner Bros. | false |
| 21 | The Lincoln Lawyer | - | - | - | $1,721 | 5 | $12,892 | May 25 | - | false |
| 22 | Montevideo: Taste of a Dream | - | - | - | $1,697 | 19 | $2,192,931 | Dec 23 | - | false |
| 23 | Love & Other Drugs | - | - | - | $1,688 | 4 | $23,524 | Mar 17 | 20th Century Fox International | false |
| 24 | The Ages of Love | - | - | - | $1,510 | 2 | $34,784 | May 25 | - | false |
| 25 | Battle Los Angeles | - | - | - | $1,298 | 6 | $28,396 | Mar 17 | Sony Pictures Releasing | false |
| 26 | Drive Angry | - | - | - | $1,000 | 8 | $41,251 | Mar 3 | Warner Bros. | false |
| 27 | Something Borrowed | - | - | - | $994 | 3 | $25,563 | May 12 | - | false |
| 28 | Sucker Punch | - | - | - | $869 | 7 | $15,446 | Mar 24 | Warner Bros. | false |
| 29 | Hall Pass | - | - | - | $782 | 7 | $33,345 | Mar 17 | Warner Bros. | false |
| 30 | He Ain't Like That | - | - | - | $729 | 9 | $62,358 | Mar 17 | - | false |
| 31 | How Do You Know | - | - | - | $577 | 6 | $27,087 | Feb 24 | Sony Pictures Releasing | false |
| 32 | You Will Meet a Tall Dark Stranger | - | - | - | $259 | 2 | $19,538 | Mar 3 | - | false |
| 33 | Paul | - | - | - | $187 | 5 | $13,124 | Apr 7 | United International Pictures | false |
| 34 | Rabbit Hole | - | - | - | $140 | 2 | $8,724 | Apr 7 | - | false |
| 35 | 127 Hours | - | - | - | $131 | 3 | $37,495 | Mar 3 | 20th Century Fox International | false |
| 36 | Yogi Bear | - | - | - | $111 | 12 | $44,085 | Feb 3 | Warner Bros. | false |
| 37 | The Enemy | - | - | - | $42 | 7 | $32,764 | Mar 10 | - | false |
| 38 | The Adjustment Bureau | - | - | - | $40 | 5 | $50,207 | Mar 3 | United International Pictures | false |
