| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $2,801,477 | 109 | $6,569,664 | May 20 | Walt Disney Pictures | false |
| 2 | Rio | - | - | - | $2,130,137 | 77 | $8,133,434 | Apr 8 | 20th Century Fox International | false |
| 3 | Thor | - | - | - | $1,902,056 | 74 | $2,647,111 | Apr 29 | United International Pictures | false |
| 4 | Big Mommas: Like Father, Like Son | - | - | - | $927,931 | 47 | $1,430,585 | May 13 | 20th Century Fox International | false |
| 5 | Just Go with It | - | - | - | $849,233 | 71 | $2,805,280 | Apr 15 | Sony Pictures Releasing | false |
| 6 | Priest | - | - | - | $787,028 | 76 | $838,443 | May 13 | Sony Pictures Releasing | false |
| 7 | Gnomeo & Juliet | - | - | - | $429,899 | 34 | $472,923 | May 6 | - | false |
| 8 | The Switch | - | - | - | $399,178 | 28 | $447,620 | May 13 | - | false |
| 9 | The Hangover Part II | - | - | - | $387,664 | 62 | $2,600,995 | May 27 | Warner Bros. | false |
| 10 | Red Riding Hood | - | - | - | $212,848 | 46 | $757,472 | Apr 22 | Warner Bros. | false |
| 11 | Hop | - | - | - | $158,232 | 72 | $1,325,821 | Apr 15 | United International Pictures | false |
| 12 | The Roommate | - | - | - | $144,411 | 30 | $232,725 | Apr 29 | Sony Pictures Releasing | false |
| 13 | Hall Pass | - | - | - | $105,250 | 40 | $1,106,944 | Apr 1 | Warner Bros. | false |
| 14 | Love & Other Drugs | - | - | - | $103,578 | 20 | $127,444 | May 20 | 20th Century Fox International | false |
| 15 | Black Swan | - | - | - | $100,667 | 32 | $428,095 | Apr 22 | 20th Century Fox International | false |
| 16 | I Spit on Your Grave | - | - | - | $91,354 | 20 | $91,354 | May 6 | - | false |
| 17 | El último cuerpo | - | - | - | $84,921 | 24 | $159,940 | May 13 | - | false |
| 18 | Drive Angry | - | - | - | $74,995 | 44 | $721,493 | Apr 15 | Warner Bros. | false |
| 19 | The Crazies | - | - | - | $58,293 | 15 | $315,322 | May 27 | - | false |
| 20 | The Rebound | - | - | - | $56,133 | 6 | $105,296 | May 13 | - | false |
| 21 | 127 Hours | - | - | - | $48,330 | 8 | $51,876 | May 13 | 20th Century Fox International | false |
| 22 | The Ghost Writer | - | - | - | $32,819 | 7 | $66,393 | Apr 29 | - | false |
| 23 | Beyond a Reasonable Doubt | - | - | - | $32,508 | 15 | $103,642 | May 27 | - | false |
| 24 | Mother and Child | - | - | - | $32,401 | 4 | $32,401 | May 6 | - | false |
| 25 | Biutiful | - | - | - | $26,490 | 4 | $54,699 | May 20 | - | false |
| 26 | A Turtle's Tale: Sammy's Adventures | - | - | - | $10,302 | 35 | $612,946 | Mar 25 | - | false |
| 27 | African Cats | - | - | - | $10,072 | 11 | $39,973 | Apr 22 | Walt Disney Pictures | false |
| 28 | Julia's Eyes | - | - | - | $9,317 | 29 | $200,750 | Apr 1 | United International Pictures | false |
| 29 | Paris 36 | - | - | - | $8,058 | 3 | $94,140 | Apr 15 | - | false |
| 30 | Sucker Punch | - | - | - | $7,268 | 41 | $333,422 | Apr 8 | Warner Bros. | false |
| 31 | The Kid Who Lies | - | - | - | $3,626 | 17 | $736,372 | Jan 28 | - | false |
| 32 | Rango | - | - | - | $3,538 | 65 | $2,327,609 | Mar 4 | United International Pictures | false |
| 33 | Mars Needs Moms | - | - | - | $1,448 | 45 | $1,174,443 | Mar 11 | Walt Disney Pictures | false |
