| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $2,106,648 | 192 | $3,152,332 | May 19 | Walt Disney Pictures | false |
| 2 | Fast Five | - | - | - | $1,986,975 | 77 | $2,211,004 | May 5 | Universal Pictures International (UPI) | false |
| 3 | Thor | - | - | - | $1,316,131 | 107 | $1,970,451 | Apr 28 | Paramount Pictures International | false |
| 4 | Gnomeo & Juliet | - | - | - | $572,551 | 56 | $613,958 | May 5 | - | false |
| 5 | Rio | - | - | - | $432,392 | 78 | $3,854,491 | Apr 7 | 20th Century Fox International | false |
| 6 | The Hangover Part II | - | - | - | $244,980 | 84 | $774,605 | May 26 | Warner Bros. | false |
| 7 | Hop | - | - | - | $167,798 | 52 | $774,000 | Apr 21 | Universal Pictures International (UPI) | false |
| 8 | Arthur | - | - | - | $160,390 | 26 | $187,726 | May 5 | Warner Bros. | false |
| 9 | Water for Elephants | - | - | - | $149,238 | 20 | $261,890 | Apr 28 | 20th Century Fox International | false |
| 10 | Red Riding Hood | - | - | - | $134,814 | 25 | $509,891 | Apr 21 | Warner Bros. | false |
| 11 | I Spit on Your Grave | - | - | - | $129,802 | 40 | $222,714 | Apr 28 | - | false |
| 12 | The Adjustment Bureau | - | - | - | $84,975 | 31 | $237,319 | May 26 | Universal Pictures International (UPI) | false |
| 13 | Stone | - | - | - | $84,104 | 15 | $123,863 | May 19 | - | false |
| 14 | Winnie the Pooh | - | - | - | $79,886 | 22 | $83,940 | May 5 | Walt Disney Pictures | false |
| 15 | Solitary Man | - | - | - | $78,134 | 13 | $78,134 | May 12 | - | false |
| 16 | The Missing Lynx 2010 Re-release | - | - | - | $45,140 | 26 | $110,191 | May 26 | - | false |
| 17 | Just Go with It | - | - | - | $39,597 | 42 | $997,060 | Mar 31 | Sony Pictures Releasing | false |
| 18 | Coming Soon | - | - | - | $38,414 | 20 | $184,191 | Apr 7 | - | false |
| 19 | Nowhere Boy | - | - | - | $37,306 | 12 | $40,441 | May 5 | - | false |
| 20 | Birds of America | - | - | - | $28,619 | 20 | $132,398 | May 12 | - | false |
| 21 | Hall Pass | - | - | - | $19,331 | 25 | $211,535 | Mar 24 | Warner Bros. | false |
| 22 | Qué pena tu vida | - | - | - | $18,241 | 20 | $91,959 | Apr 14 | - | false |
| 23 | The Roommate | - | - | - | $17,856 | 14 | $58,928 | Apr 28 | Sony Pictures Releasing | false |
| 24 | I Am Number Four | - | - | - | $10,598 | 28 | $161,408 | Feb 24 | Walt Disney Pictures | false |
| 25 | Drive Angry | - | - | - | $8,805 | 37 | $255,370 | Mar 31 | Warner Bros. | false |
| 26 | Sucker Punch | - | - | - | $7,955 | 21 | $108,466 | Apr 7 | Warner Bros. | false |
| 27 | Big Mommas: Like Father, Like Son | - | - | - | $7,339 | 31 | $642,257 | Mar 17 | 20th Century Fox International | false |
| 28 | The Invisible Eye | - | - | - | $5,542 | 4 | $5,542 | May 12 | - | false |
| 29 | How Do You Know | - | - | - | $5,392 | 14 | $168,868 | Feb 10 | Sony Pictures Releasing | false |
| 30 | The Messenger | - | - | - | $5,165 | 7 | $36,414 | Mar 31 | - | false |
| 31 | Agora | - | - | - | $3,353 | 18 | $157,325 | Apr 7 | - | false |
| 32 | Brothers | - | - | - | $2,965 | 12 | $90,330 | Apr 14 | - | false |
| 33 | Mars Needs Moms | - | - | - | $2,123 | 44 | $218,093 | Mar 17 | Walt Disney Pictures | false |
| 34 | Carancho | - | - | - | $1,332 | 7 | $27,372 | Apr 14 | - | false |
| 35 | The Burning Plain | - | - | - | $1,137 | 10 | $36,976 | Apr 21 | - | false |
| 36 | Justin Bieber: Never Say Never | - | - | - | $612 | 22 | $356,727 | Mar 24 | Paramount Pictures International | false |
| 37 | Y si te vi, no me acuerdo | - | - | - | $478 | 4 | $6,173 | May 5 | - | false |
