| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $13,461,840 | 949 | $24,461,143 | May 18 | Walt Disney Pictures | false |
| 2 | Fast Five | - | - | - | $12,687,861 | 552 | $15,494,242 | May 4 | Universal Pictures International (UPI) | false |
| 3 | Thor | - | - | - | $5,143,943 | 581 | $10,900,780 | Apr 27 | Universal Pictures International (UPI) | false |
| 4 | Red | - | - | - | $3,201,906 | 396 | $4,037,945 | May 11 | Medusa Distribuzione | false |
| 5 | The Hangover Part II | - | - | - | $3,145,311 | 576 | $13,505,147 | May 27 | Warner Bros. | false |
| 6 | Beastly | - | - | - | $1,711,231 | 259 | $2,058,442 | May 11 | - | false |
| 7 | Source Code | - | - | - | $1,562,773 | 309 | $2,718,562 | Apr 29 | 01 Distribution | false |
| 8 | The Tree of Life | - | - | - | $1,470,612 | 181 | $3,863,901 | May 18 | 01 Distribution | false |
| 9 | Water for Elephants | - | - | - | $1,422,803 | 317 | $1,465,985 | May 6 | 20th Century Fox International | false |
| 10 | We Have a Pope | - | - | - | $1,422,407 | 453 | $7,894,680 | Apr 15 | 01 Distribution | false |
| 11 | Machete | - | - | - | $1,320,510 | 218 | $1,359,299 | May 6 | Lucky Red | false |
| 12 | Rio | - | - | - | $1,013,783 | 626 | $9,204,958 | Apr 15 | 20th Century Fox International | false |
| 13 | The Beaver | - | - | - | $824,071 | 270 | $1,084,923 | May 20 | - | false |
| 14 | Make a Fake | - | - | - | $694,847 | 128 | $731,299 | May 6 | 01 Distribution | false |
| 15 | Faccio un salto all'Avana | - | - | - | $598,589 | 331 | $4,032,630 | Apr 22 | Medusa Distribuzione | false |
| 16 | Limitless | - | - | - | $543,264 | 260 | $5,477,558 | Apr 15 | Eagle Pictures | false |
| 17 | Julia's Eyes | - | - | - | $444,032 | 155 | $622,776 | May 11 | Moviemax | false |
| 18 | The Dilemma | - | - | - | $383,876 | 102 | $405,477 | May 20 | - | false |
| 19 | The Kid with a Bike | - | - | - | $329,053 | 63 | $1,106,665 | May 18 | Lucky Red | false |
| 20 | Tatanka | - | - | - | $260,434 | 164 | $260,434 | May 6 | Bolero Film | false |
| 21 | Red Riding Hood | - | - | - | $250,143 | 286 | $2,578,521 | Apr 22 | Warner Bros. | false |
| 22 | Angel & Tony | - | - | - | $159,389 | 27 | $261,097 | Apr 29 | Sacher Distribuzione | false |
| 23 | The First Assignment | - | - | - | $154,834 | 21 | $260,294 | May 6 | Teodora Film | false |
| 24 | Route Irish | - | - | - | $151,723 | 70 | $555,955 | Apr 20 | BIM Distribuzione | false |
| 25 | The Extra Man | - | - | - | $135,981 | 48 | $143,341 | May 13 | BIM Distribuzione | false |
| 26 | Notizie degli scavi | - | - | - | $107,239 | 21 | $205,338 | Apr 29 | - | false |
| 27 | Lost Kisses | - | - | - | $67,772 | 41 | $151,454 | Apr 29 | - | false |
| 28 | Outside the Law | - | - | - | $59,466 | 42 | $67,045 | May 11 | Eagle Pictures | false |
| 29 | We Believed | - | - | - | $49,954 | 77 | $2,124,145 | Nov 12 | 01 Distribution | false |
| 30 | Balla con noi - Let's Dance | - | - | - | $49,921 | 39 | $67,512 | May 27 | - | false |
| 31 | The End Is My Beginning | - | - | - | $49,438 | 100 | $1,178,390 | Apr 1 | Fandango | false |
| 32 | The Housemaid | - | - | - | $48,899 | 59 | $129,421 | May 27 | Fandango | false |
| 33 | Corpo Celeste 2011 Re-release | - | - | - | $42,355 | 23 | $306,413 | May 27 | - | false |
| 34 | The Next Three Days | - | - | - | $41,279 | 469 | $4,371,936 | Apr 8 | Medusa Distribuzione | false |
| 35 | The Fast and the Furious | - | - | - | $39,770 | 9 | $2,851,994 | Sep 21 | United International Pictures | false |
| 36 | Afraid of the Dark (Bruises) | - | - | - | $36,438 | 41 | $36,438 | May 6 | BIM Distribuzione | false |
| 37 | The House by the Medlar Tree | - | - | - | $32,487 | 22 | $61,010 | Mar 4 | - | false |
| 38 | Mars Needs Moms | - | - | - | $29,388 | 3 | $29,388 | Jun 1 | Walt Disney Pictures | false |
| 39 | Winnie the Pooh | - | - | - | $25,235 | 67 | $153,233 | Apr 20 | Walt Disney Pictures | false |
| 40 | Poetry | - | - | - | $22,674 | 24 | $252,125 | Apr 1 | - | false |
| 41 | Incendies | - | - | - | $17,584 | 35 | $688,878 | Jan 21 | Lucky Red | false |
| 42 | Battle Los Angeles | - | - | - | $15,953 | 172 | $1,027,709 | Apr 22 | Sony Pictures Releasing | false |
| 43 | Offside 2011 Re-release | - | - | - | $13,179 | 22 | $124,637 | Apr 8 | Bolero Film | false |
| 44 | Cirkus Columbia | - | - | - | $13,059 | 18 | $46,445 | May 27 | Archibald | false |
| 45 | Et in terra pax | - | - | - | $10,473 | 3 | $34,007 | May 27 | - | false |
| 46 | Il mercante di stoffe | - | - | - | $6,659 | 9 | $7,272 | May 13 | - | false |
| 47 | Questo mondo è per te | - | - | - | $5,570 | 5 | $65,444 | Apr 1 | - | false |
| 48 | Mia and the Migoo 2010 Re-release | - | - | - | $4,858 | 4 | $35,873 | Nov 26 | - | false |
| 49 | La misura del confine | - | - | - | $3,171 | 2 | $9,887 | May 6 | - | false |
| 50 | Il colore del vento | - | - | - | $2,254 | 2 | $7,775 | Apr 15 | Teodora Film | false |
| 51 | Hereafter | - | - | - | $2,188 | 371 | $11,240,698 | Jan 5 | Warner Bros. | false |
| 52 | 20 Cigarettes | - | - | - | $1,734 | 2 | $353,601 | - | - | false |
| 53 | Invictus | - | - | - | $1,675 | 418 | $9,063,387 | Feb 26 | Warner Bros. | false |
| 54 | The Immature | - | - | - | $1,661 | 519 | $21,858,834 | Jan 21 | Medusa Distribuzione | false |
| 55 | Love & Other Drugs | - | - | - | $1,306 | 310 | $5,098,694 | Feb 18 | Medusa Distribuzione | false |
| 56 | The Salt of Life | - | - | - | $1,250 | 182 | $1,135,249 | Feb 11 | 01 Distribution | false |
| 57 | Skyline | - | - | - | $1,191 | 238 | $2,238,925 | Jan 14 | Eagle Pictures | false |
| 58 | Inception | - | - | - | $1,186 | 585 | $15,459,083 | Sep 24 | Warner Bros. | false |
| 59 | Silvio Forever | - | - | - | $1,106 | 104 | $532,916 | Mar 25 | Lucky Red | false |
| 60 | Like Water for Chocolate 2011 Re-release | - | - | - | $872 | 1 | $78,733 | May 6 | - | false |
| 61 | The City of Your Final Destination | - | - | - | $679 | 58 | $916,654 | Oct 8 | Teodora Film | false |
| 62 | 40% - Le mani libere del destino | - | - | - | $617 | 1 | $11,626 | Oct 22 | - | false |
| 63 | Red Like the Sky | - | - | - | $573 | 4 | $194,758 | Mar 30 | Lady Film | false |
| 64 | In a Better World | - | - | - | $506 | 40 | $807,897 | Dec 10 | Teodora Film | false |
| 65 | Burlesque | - | - | - | $496 | 149 | $920,192 | Feb 11 | Sony Pictures Releasing | false |
| 66 | The Father and the Foreigner | - | - | - | $307 | 110 | $171,610 | Feb 18 | 01 Distribution | false |
