| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $393,832 | 9 | $672,162 | May 18 | Universal Pictures International (UPI) | false |
| 2 | Fast Five | - | - | - | $209,368 | 9 | $255,722 | May 6 | Universal Pictures International (UPI) | false |
| 3 | The Hangover Part II | - | - | - | $74,316 | 8 | $343,086 | May 27 | ACME | false |
| 4 | Thor | - | - | - | $73,798 | 9 | $128,052 | Apr 29 | Universal Pictures International (UPI) | false |
| 5 | Rio | - | - | - | $52,615 | 13 | $384,241 | Apr 8 | Universal Pictures International (UPI) | false |
| 6 | Water for Elephants | - | - | - | $44,219 | 4 | $64,676 | May 13 | Universal Pictures International (UPI) | false |
| 7 | Priest | - | - | - | $37,625 | 6 | $40,808 | May 13 | ACME | false |
| 8 | Something Borrowed | - | - | - | $27,761 | 2 | $30,631 | May 6 | ACME | false |
| 9 | Hall Pass | - | - | - | $22,658 | 3 | $91,347 | Apr 15 | ACME | false |
| 10 | Red Riding Hood | - | - | - | $22,191 | 3 | $36,024 | Apr 29 | ACME | false |
| 11 | Blitz | - | - | - | $14,285 | 2 | $14,285 | May 20 | ACME | false |
| 12 | Paul | - | - | - | $10,239 | 3 | $39,299 | Apr 22 | Universal Pictures International (UPI) | false |
| 13 | Hop | - | - | - | $6,410 | 8 | $104,998 | Apr 1 | Universal Pictures International (UPI) | false |
| 14 | Beastly | - | - | - | $4,749 | 4 | $9,192 | May 27 | Aurum Films | false |
| 15 | Source Code | - | - | - | $3,674 | 2 | $54,898 | Apr 8 | ACME | false |
| 16 | The King's Speech | - | - | - | $896 | 2 | $180,778 | Jan 21 | ACME | false |
