| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $6,964,803 | 317 | $11,696,923 | May 19 | Walt Disney Pictures | false |
| 2 | Fast Five | - | - | - | $5,274,894 | 102 | $6,337,752 | May 5 | Universal Pictures International (UPI) | false |
| 3 | Rio | - | - | - | $2,259,627 | 115 | $9,439,638 | Apr 7 | 20th Century Fox International | false |
| 4 | Thor | - | - | - | $1,619,565 | 160 | $2,399,738 | Apr 28 | Paramount Pictures International | false |
| 5 | Gnomeo & Juliet | - | - | - | $600,053 | 61 | $624,738 | May 5 | - | false |
| 6 | The Lincoln Lawyer | - | - | - | $579,245 | 48 | $619,729 | May 5 | Distribution Company | false |
| 7 | The Hangover Part II | - | - | - | $502,313 | 69 | $2,808,879 | May 26 | Warner Bros. | false |
| 8 | Chinese Take-Away | - | - | - | $465,064 | 79 | $4,416,901 | Mar 24 | Walt Disney Pictures | false |
| 9 | Scream 4 | - | - | - | $386,663 | 50 | $571,673 | Apr 28 | Alfa Films | false |
| 10 | Just Go with It | - | - | - | $346,194 | 45 | $904,659 | Apr 21 | Sony Pictures Releasing | false |
| 11 | Water for Elephants | - | - | - | $317,640 | 30 | $426,644 | May 5 | 20th Century Fox International | false |
| 12 | Whatever Works | - | - | - | $297,609 | 24 | $470,086 | May 12 | - | false |
| 13 | Red Riding Hood | - | - | - | $278,364 | 44 | $812,221 | Apr 21 | Warner Bros. | false |
| 14 | San Martín: El cruce de Los Andes | - | - | - | $206,392 | 60 | $316,613 | Apr 7 | Distribution Company | false |
| 15 | Insidious | - | - | - | $181,297 | 49 | $637,019 | May 26 | Distribution Company | false |
| 16 | Fair Game | - | - | - | $163,394 | 18 | $182,990 | May 12 | Alfa Films | false |
| 17 | Potiche | - | - | - | $144,929 | 19 | $163,230 | May 12 | Distribution Company | false |
| 18 | Winnie the Pooh | - | - | - | $125,465 | 46 | $148,727 | May 12 | Walt Disney Pictures | false |
| 19 | Los Marziano | - | - | - | $117,067 | 62 | $1,063,465 | Apr 14 | 20th Century Fox International | false |
| 20 | Hop | - | - | - | $96,936 | 72 | $564,769 | Apr 21 | Universal Pictures International (UPI) | false |
| 21 | Hall Pass | - | - | - | $80,154 | 43 | $633,347 | Apr 7 | Warner Bros. | false |
| 22 | My Afternoons with Margueritte | - | - | - | $72,900 | 11 | $134,248 | Apr 28 | CDI Films | false |
| 23 | African Cats | - | - | - | $50,993 | 19 | $105,627 | Apr 28 | Walt Disney Pictures | false |
| 24 | Soul Kitchen | - | - | - | $38,741 | 5 | $44,376 | May 5 | Alfa Films | false |
| 25 | The Cat Vanishes | - | - | - | $36,534 | 37 | $208,868 | Apr 21 | Walt Disney Pictures | false |
| 26 | Querida voy a comprar cigarrillos y vuelvo | - | - | - | $33,592 | 13 | $37,138 | May 5 | Primer Plano Film Group | false |
| 27 | The Finger | - | - | - | $33,413 | 15 | $63,492 | May 26 | Primer Plano Film Group | false |
| 28 | Incendies | - | - | - | $32,223 | 8 | $84,357 | May 26 | Alfa Films | false |
| 29 | Le Quattro Volte | - | - | - | $17,844 | 4 | $32,878 | May 19 | - | false |
| 30 | Torrente 4: Lethal Crisis | - | - | - | $16,175 | 51 | $539,738 | Apr 14 | CDI Films | false |
| 31 | Uncle Boonmee Who Can Recall His Past Lives | - | - | - | $14,517 | 5 | $42,809 | Apr 21 | - | false |
| 32 | Season of the Witch | - | - | - | $10,156 | 48 | $847,437 | Mar 31 | - | false |
| 33 | No Strings Attached | - | - | - | $7,889 | 40 | $1,366,277 | Feb 24 | Paramount Pictures International | false |
| 34 | The Concert | - | - | - | $7,446 | 18 | $140,634 | Mar 10 | Alfa Films | false |
| 35 | The King's Speech | - | - | - | $4,195 | 53 | $2,649,964 | Feb 10 | - | false |
| 36 | Black Swan | - | - | - | $2,576 | 59 | $1,967,697 | Feb 17 | 20th Century Fox International | false |
| 37 | Cruzadas | - | - | - | $2,326 | 35 | $61,359 | Apr 21 | Primer Plano Film Group | false |
| 38 | The Rite | - | - | - | $1,683 | 66 | $3,125,253 | Feb 10 | Warner Bros. | false |
| 39 | Morning Glory | - | - | - | $1,262 | 33 | $277,897 | Mar 17 | Paramount Pictures International | false |
| 40 | Ajami | - | - | - | $777 | 4 | $20,173 | Apr 14 | Primer Plano Film Group | false |
| 41 | Tangled | - | - | - | $503 | 103 | $8,228,969 | Jan 6 | Walt Disney Pictures | false |
| 42 | The World is Big and Salvation Lurks Around the Corner | - | - | - | $420 | 6 | $17,949 | Mar 24 | IFA | false |
| 43 | Mars Needs Moms | - | - | - | $372 | 65 | $1,064,388 | Mar 24 | Walt Disney Pictures | false |
| 44 | Justin Bieber: Never Say Never | - | - | - | $346 | 71 | $651,935 | Feb 24 | Paramount Pictures International | false |
| 45 | Battle Los Angeles | - | - | - | $282 | 51 | $987,555 | Mar 10 | Sony Pictures Releasing | false |
