| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $279,653,149 | 4,390 | $312,433,331 | May 7 | Paramount Pictures | false |
| 2 | Shrek Forever After | - | - | - | $146,810,785 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 3 | Robin Hood | - | - | - | $86,144,405 | 3,505 | $105,269,730 | May 14 | Universal Pictures | false |
| 4 | Sex and the City 2 | - | - | - | $51,043,450 | 3,445 | $95,347,692 | May 27 | Warner Bros. | false |
| 5 | A Nightmare on Elm Street | - | - | - | $46,170,466 | 3,332 | $63,075,011 | Apr 30 | Warner Bros. | false |
| 6 | Letters to Juliet | - | - | - | $38,195,942 | 2,975 | $53,032,453 | May 14 | Summit Entertainment | false |
| 7 | Prince of Persia: The Sands of Time | - | - | - | $37,813,075 | 3,646 | $90,759,676 | May 28 | Walt Disney Studios Motion Pictures | false |
| 8 | How to Train Your Dragon | - | - | - | $29,022,082 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 9 | Date Night | - | - | - | $25,519,221 | 3,380 | $98,711,404 | Apr 9 | Twentieth Century Fox | false |
| 10 | Just Wright | - | - | - | $18,833,220 | 1,831 | $21,540,363 | May 14 | - | false |
| 11 | The Back-up Plan | - | - | - | $18,469,490 | 3,280 | $37,490,007 | Apr 23 | CBS Films | false |
| 12 | Furry Vengeance | - | - | - | $14,749,772 | 3,002 | $17,630,465 | Apr 30 | Summit Entertainment | false |
| 13 | Clash of the Titans | - | - | - | $11,657,169 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 14 | Death at a Funeral | - | - | - | $9,926,295 | 2,459 | $42,739,347 | Apr 16 | Screen Gems | false |
| 15 | The Losers | - | - | - | $9,203,480 | 2,936 | $23,591,432 | Apr 23 | Warner Bros. | false |
| 16 | Kick-Ass | - | - | - | $8,440,353 | 3,065 | $48,071,303 | Apr 16 | Lionsgate Films | false |
| 17 | MacGruber | - | - | - | $7,674,445 | 2,551 | $8,525,600 | May 21 | Universal Pictures | false |
| 18 | Oceans | - | - | - | $7,008,773 | 1,232 | $19,422,319 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 19 | Babies | - | - | - | $6,090,771 | 543 | $7,320,323 | May 7 | Focus Features | false |
| 20 | The Last Song | - | - | - | $4,650,650 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 21 | Alice in Wonderland | - | - | - | $3,827,038 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 22 | City Island | - | - | - | $3,302,790 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 23 | Hot Tub Time Machine | - | - | - | $3,155,632 | 2,771 | $50,287,556 | Mar 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 24 | Hubble | - | - | - | $2,800,547 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 25 | Diary of a Wimpy Kid | - | - | - | $2,613,532 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 26 | The Girl with the Dragon Tattoo | - | - | - | $2,573,416 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 27 | The Secret in Their Eyes | - | - | - | $2,492,494 | 166 | $6,391,436 | Apr 16 | Sony Pictures Classics | false |
| 28 | Avatar | - | - | - | $2,242,990 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 29 | The Bounty Hunter | - | - | - | $2,147,126 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 30 | Why Did I Get Married Too? | - | - | - | $1,818,019 | 2,155 | $60,095,852 | Apr 2 | Lionsgate Films | false |
| 31 | Kites | - | - | - | $1,497,645 | 207 | $1,643,486 | May 21 | Reliance Big Pictures | false |
| 32 | Shutter Island | - | - | - | $1,422,311 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 33 | Exit Through the Gift Shop | - | - | - | $1,381,667 | 46 | $3,291,250 | Apr 16 | - | false |
| 34 | Please Give | - | - | - | $1,289,472 | 272 | $4,033,574 | Apr 30 | Sony Pictures Classics | false |
| 35 | She's Out of My League | - | - | - | $1,150,100 | 2,958 | $32,010,860 | Mar 12 | Paramount Pictures | false |
| 36 | The Ghost Writer | - | - | - | $1,075,879 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 37 | Housefull | - | - | - | $1,069,285 | 82 | $1,183,658 | Apr 30 | Eros Worldwide | false |
| 38 | Harry Brown | - | - | - | $983,278 | 67 | $1,818,681 | Apr 30 | The Samuel Goldwyn Company | false |
| 39 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $744,880 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 40 | Princess Kaiulani | - | - | - | $626,985 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 41 | Tooth Fairy | - | - | - | $523,020 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 42 | Under the Sea 3D | - | - | - | $470,356 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 43 | La Mission | - | - | - | $427,080 | 47 | $1,062,941 | Apr 9 | Screen Media Films | false |
| 44 | Greenberg | - | - | - | $412,624 | 186 | $4,234,170 | Mar 19 | Focus Features | false |
| 45 | Our Family Wedding | - | - | - | $368,440 | 1,609 | $20,255,281 | Mar 12 | - | false |
| 46 | Mother and Child | - | - | - | $315,311 | 119 | $1,110,509 | May 7 | Sony Pictures Classics | false |
| 47 | The Joneses | - | - | - | $294,605 | 217 | $1,475,746 | Apr 16 | Roadside Attractions | false |
| 48 | The Crazies | - | - | - | $290,274 | 2,479 | $39,123,589 | Feb 26 | Overture Films | false |
| 49 | Letters to God | - | - | - | $273,264 | 897 | $2,848,578 | Apr 9 | Vivendi Entertainment | false |
| 50 | Solitary Man | - | - | - | $243,087 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 51 | Magnificent Desolation: Walking on the Moon | - | - | - | $231,278 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 52 | The Runaways | - | - | - | $215,885 | 244 | $3,573,673 | Mar 19 | Apparition | false |
| 53 | Chloe | - | - | - | $202,073 | 350 | $3,075,255 | Mar 26 | Sony Pictures Classics | false |
| 54 | Iron Man | - | - | - | $192,025 | 4,154 | $318,604,126 | May 2 | Paramount Pictures | false |
| 55 | Mid-August Lunch | - | - | - | $191,665 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 56 | Cop Out | - | - | - | $185,494 | 3,150 | $44,875,481 | Feb 26 | Warner Bros. | false |
| 57 | Crazy Heart | - | - | - | $177,809 | 1,361 | $39,464,306 | Dec 16 | - | false |
| 58 | The Secret of Kells | - | - | - | $159,067 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 59 | The Square 2010 Re-release | - | - | - | $144,086 | 24 | $406,116 | Apr 9 | Apparition | false |
| 60 | Brooklyn's Finest | - | - | - | $143,269 | 1,939 | $27,163,593 | Mar 5 | Overture Films | false |
| 61 | The City of Your Final Destination | - | - | - | $140,431 | 26 | $493,296 | Apr 16 | Screen Media Films | false |
| 62 | Metropolis 2010 Re-release | - | - | - | $135,989 | 9 | $529,603 | May 7 | Kino International | false |
| 63 | The Human Centipede (First Sequence) | - | - | - | $130,149 | 19 | $181,467 | Apr 30 | IFC Films | false |
| 64 | Casino Jack and the United States of Money | - | - | - | $129,094 | 21 | $176,865 | May 7 | Magnolia Pictures | false |
| 65 | A Prophet | - | - | - | $127,288 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 66 | Vincere | - | - | - | $118,970 | 36 | $619,162 | Mar 19 | IFC Films | false |
| 67 | Holy Rollers | - | - | - | $107,270 | 20 | $303,064 | May 21 | First Independent Pictures | false |
| 68 | Broken Embraces | - | - | - | $101,221 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 69 | Deep Sea | - | - | - | $100,397 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 70 | North Face | - | - | - | $90,176 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 71 | The Perfect Game | - | - | - | $88,881 | 417 | $1,037,071 | Apr 16 | - | false |
| 72 | The Good the Bad the Weird | - | - | - | $87,733 | 15 | $128,486 | Apr 23 | IFC Films | false |
| 73 | Touching Home | - | - | - | $87,710 | 7 | $116,353 | Apr 30 | CFI Releasing | false |
| 74 | The Last Station | - | - | - | $84,702 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 75 | Green Zone | - | - | - | $82,385 | 3,004 | $35,053,660 | Mar 12 | Universal Pictures | false |
| 76 | The Book of Eli | - | - | - | $81,874 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 77 | Remember Me | - | - | - | $81,033 | 2,215 | $19,068,240 | Mar 12 | Summit Entertainment | false |
| 78 | Sea Monsters: A Prehistoric Adventure | - | - | - | $71,529 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 79 | The Art of the Steal | - | - | - | $68,033 | 34 | $544,890 | Feb 26 | IFC Films | false |
| 80 | Only the Brave | - | - | - | $58,637 | 5 | $150,000 | May 28 | Indican Pictures | false |
| 81 | Mother | - | - | - | $55,516 | 38 | $551,509 | Mar 12 | Magnolia Pictures | false |
| 82 | When You're Strange | - | - | - | $53,083 | 8 | $246,078 | Apr 9 | Abramorama | false |
| 83 | OSS 117: Lost in Rio | - | - | - | $48,337 | 7 | $89,375 | May 7 | Music Box Films | false |
| 84 | Valley of the Heart's Delight | - | - | - | $48,258 | 8 | $119,290 | Apr 9 | Indican Pictures | false |
| 85 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $44,232 | 12 | $453,993 | Jan 29 | First Run | false |
| 86 | Father of My Children | - | - | - | $43,982 | 7 | $144,022 | May 21 | IFC Films | false |
| 87 | Ajami | - | - | - | $43,476 | 23 | $622,403 | Feb 3 | Kino International | false |
| 88 | Survival of the Dead | - | - | - | $40,192 | 20 | $101,740 | May 28 | Magnolia Pictures | false |
| 89 | Micmacs | - | - | - | $38,992 | 52 | $1,262,079 | May 28 | Sony Pictures Classics | false |
| 90 | The Blind Side | - | - | - | $38,609 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 91 | Sweetgrass | - | - | - | $38,371 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 92 | No One Knows About Persian Cats | - | - | - | $37,944 | 12 | $81,768 | Apr 16 | IFC Films | false |
| 93 | The Cremaster Cycle 2010 Re-release | - | - | - | $36,607 | 2 | $151,239 | Apr 9 | International Film Circuit | false |
| 94 | The Eclipse | - | - | - | $32,681 | 12 | $133,411 | Mar 26 | Magnolia Pictures | false |
| 95 | Breathless 2010 Re-release | - | - | - | $31,908 | 12 | $363,031 | May 28 | Rialto Pictures | false |
| 96 | The Girl on the Train | - | - | - | $31,602 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 97 | Best Worst Movie | - | - | - | $31,303 | 2 | $109,895 | Apr 23 | Abramorama | false |
| 98 | Looking for Eric | - | - | - | $31,223 | 11 | $55,804 | May 14 | IFC Films | false |
| 99 | Kites The Remix | - | - | - | $31,191 | 40 | $41,783 | May 28 | Reliance Big Pictures | false |
| 100 | Agora | - | - | - | $30,892 | 17 | $619,423 | May 28 | Newmarket Films | false |
| 101 | Multiple Sarcasms | - | - | - | $29,731 | 15 | $29,731 | May 7 | MAC Releasing | false |
| 102 | Racing Dreams | - | - | - | $29,409 | 33 | $65,082 | May 21 | Hannover House | false |
| 103 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $25,779 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 104 | Valentine's Day | - | - | - | $25,199 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 105 | The Yellow Handkerchief | - | - | - | $23,932 | 29 | $318,623 | Feb 26 | The Samuel Goldwyn Company | false |
| 106 | 180° South | - | - | - | $22,997 | 4 | $31,745 | May 21 | Magnolia Pictures | false |
| 107 | Dancing Across Borders | - | - | - | $22,739 | 5 | $66,166 | Mar 26 | First Run | false |
| 108 | The White Ribbon | - | - | - | $22,544 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 109 | The Warlords | - | - | - | $21,504 | 12 | $129,078 | Apr 2 | Magnolia Pictures | false |
| 110 | Daddy Longlegs | - | - | - | $20,239 | 2 | $21,766 | May 14 | IFC Films | false |
| 111 | The Oath | - | - | - | $20,137 | 4 | $42,273 | May 7 | Zeitgeist Films | false |
| 112 | Terribly Happy | - | - | - | $20,112 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 113 | Beetle Queen Conquers Tokyo | - | - | - | $19,588 | 3 | $32,308 | May 12 | Argot Pictures | false |
| 114 | The Good Heart | - | - | - | $19,560 | 6 | $20,930 | Apr 30 | Magnolia Pictures | false |
| 115 | Everyone Else | - | - | - | $19,297 | 5 | $102,042 | Apr 9 | The Cinema Guild | false |
| 116 | Mademoiselle Chambon | - | - | - | $19,164 | 16 | $531,685 | May 28 | Lorber Films | false |
| 117 | Two in the Wave | - | - | - | $18,684 | 1 | $28,808 | May 19 | Lorber Films | false |
| 118 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $17,826 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 119 | House | - | - | - | $17,132 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 120 | Breath Made Visible: Anna Halprin | - | - | - | $16,523 | 3 | $52,387 | Apr 2 | Argot Pictures | false |
| 121 | The Harimaya Bridge | - | - | - | $16,017 | 3 | $54,473 | Mar 12 | Eleven Arts | false |
| 122 | Here and There | - | - | - | $15,757 | 5 | $27,156 | May 14 | Cinema Purgatorio | false |
| 123 | U2 3D | - | - | - | $14,553 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 124 | In My Sleep | - | - | - | $13,045 | 2 | $30,158 | Apr 23 | - | false |
| 125 | A Town Called Panic | - | - | - | $12,696 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 126 | Breaking Upwards | - | - | - | $12,413 | 5 | $77,389 | Apr 2 | IFC Films | false |
| 127 | Creation | - | - | - | $12,309 | 12 | $341,323 | Jan 22 | Newmarket Films | false |
| 128 | Fish Tank | - | - | - | $12,239 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 129 | The Messenger | - | - | - | $11,942 | 50 | $1,109,660 | Nov 13 | Oscilloscope | false |
| 130 | The Imaginarium of Doctor Parnassus | - | - | - | $11,816 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 131 | John Rabe | - | - | - | $11,557 | 6 | $67,519 | May 21 | Strand Releasing | false |
| 132 | The Living Wake | - | - | - | $10,334 | 1 | $12,232 | May 14 | Mangusta Productions | false |
| 133 | Behind the Burly Q | - | - | - | $9,155 | 2 | $23,889 | Apr 23 | First Run | false |
| 134 | Killing Kasztner | - | - | - | $9,102 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 135 | See What I'm Saying: The Deaf Entertainers Documentary | - | - | - | $8,220 | 21 | $118,206 | Mar 19 | Worldplay | false |
| 136 | Ran 2010 Re-release | - | - | - | $7,674 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 137 | Space Station 3D | - | - | - | $7,536 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 138 | That Evening Sun | - | - | - | $7,393 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 139 | Happiness Runs | - | - | - | $7,199 | 2 | $7,199 | May 7 | Strand Releasing | false |
| 140 | Feed the Fish | - | - | - | $7,005 | 4 | $101,170 | Apr 23 | Strand Releasing | false |
| 141 | Mercy | - | - | - | $6,385 | 2 | $6,780 | Apr 30 | IFC Films | false |
| 142 | Le combat dans l'île | - | - | - | $5,568 | 1 | $50,039 | Jun 12 | The Film Desk | false |
| 143 | After the Cup: Sons of Sakhnin United | - | - | - | $4,774 | 3 | $11,538 | May 21 | Variance Films | false |
| 144 | Lbs. | - | - | - | $4,062 | 1 | $29,866 | Mar 26 | Truly Indie | false |
| 145 | Dreamkiller | - | - | - | $3,922 | 3 | $15,514 | Feb 19 | Delaware Pictures | false |
| 146 | Bluebeard | - | - | - | $3,779 | 3 | $33,490 | Mar 26 | Strand Releasing | false |
| 147 | Prodigal Sons | - | - | - | $3,479 | 11 | $73,544 | Feb 26 | First Run | false |
| 148 | October Country | - | - | - | $3,212 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 149 | Harlan: In the Shadow of Jew Suess | - | - | - | $3,075 | 5 | $54,305 | Mar 3 | Zeitgeist Films | false |
| 150 | In/Significant Others | - | - | - | $2,895 | 1 | $3,763 | May 14 | North Poplar Pictures | false |
| 151 | The Trouble with Terkel 2010 Re-release | - | - | - | $2,838 | 2 | $10,783 | Mar 26 | Indican Pictures | false |
| 152 | Fresh | - | - | - | $2,836 | 3 | $25,115 | Apr 9 | - | false |
| 153 | 35 Shots of Rum | - | - | - | $2,564 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 154 | Formosa Betrayed | - | - | - | $2,562 | 16 | $225,341 | Feb 26 | Screen Media Films | false |
| 155 | The Sun Behind the Clouds: Tibet's Struggle for Freedom | - | - | - | $2,472 | 4 | $67,095 | Mar 31 | Balcony Releasing | false |
| 156 | Mississippi Mermaid | - | - | - | $2,297 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 157 | Carbon Nation | - | - | - | $1,564 | 2 | $16,901 | May 7 | Clay Way Media | false |
| 158 | Galapagos | - | - | - | $1,454 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 159 | Waking Sleeping Beauty | - | - | - | $1,392 | 5 | $80,741 | Mar 26 | Walt Disney Studios Motion Pictures | false |
| 160 | Paper Man | - | - | - | $1,374 | 3 | $13,514 | Apr 23 | MPI Media Group | false |
| 161 | The Headless Woman | - | - | - | $1,208 | 3 | $100,177 | Aug 19 | Strand Releasing | false |
| 162 | Toe to Toe | - | - | - | $1,142 | 2 | $21,648 | Feb 26 | Strand Releasing | false |
| 163 | Double Take | - | - | - | $1,140 | 1 | $20,218 | Jun 2 | Kino International | false |
| 164 | After.Life | - | - | - | $1,075 | 41 | $108,595 | Apr 9 | Anchor Bay Films | false |
| 165 | 2012: Time for Change | - | - | - | $998 | 2 | $68,339 | Apr 9 | Mangusta Productions | false |
| 166 | Small Change | - | - | - | $974 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 167 | The Secrets of Jonathan Sperry | - | - | - | $839 | 135 | $1,355,079 | Sep 18 | Five & Two Pictures | false |
| 168 | Perrier's Bounty | - | - | - | $828 | 1 | $828 | May 21 | IFC Films | false |
| 169 | Home | - | - | - | $728 | 2 | $15,925 | Nov 27 | Lorber Films | false |
| 170 | Promised Lands | - | - | - | $702 | 1 | $4,546 | Feb 5 | The Film Desk | false |
| 171 | My Name Is Khan | - | - | - | $486 | 125 | $4,018,771 | Feb 12 | - | false |
| 172 | Videocracy | - | - | - | $459 | 1 | $23,720 | Feb 12 | Kino International | false |
| 173 | Monsieur Verdoux | - | - | - | $449 | 2 | $64,636 | Mar 14 | The Film Desk | false |
| 174 | An Education | - | - | - | $384 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 175 | NoBody's Perfect 2010 Re-release | - | - | - | $354 | 1 | $2,122 | Apr 16 | Lorber Films | false |
| 176 | Four Seasons Lodge | - | - | - | $168 | 3 | $58,334 | Nov 11 | First Run | false |
