| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Robin Hood | - | - | - | $104,626 | 7 | $161,619 | May 13 | United International Pictures | false |
| 2 | Iron Man 2 | - | - | - | $39,215 | 4 | $41,653 | Apr 29 | Walt Disney Pictures | false |
| 3 | The Bounty Hunter | - | - | - | $34,302 | 6 | $62,846 | Apr 22 | Sony Pictures Releasing | false |
| 4 | Clash of the Titans | - | - | - | $32,794 | 10 | $158,605 | Apr 8 | Warner Bros. | false |
| 5 | How to Train Your Dragon | - | - | - | $30,323 | 7 | $64,614 | Apr 15 | United International Pictures | false |
| 6 | Shrek Forever After | - | - | - | $21,705 | 7 | $167,307 | May 27 | United International Pictures | false |
| 7 | Remember Me | - | - | - | $17,975 | 4 | $20,167 | Apr 29 | - | false |
| 8 | The Ghost Writer | - | - | - | $15,080 | 3 | $57,819 | May 20 | - | false |
| 9 | Date Night | - | - | - | $14,655 | 7 | $26,788 | May 20 | 20th Century Fox International | false |
| 10 | Leap Year | - | - | - | $14,060 | 3 | $14,152 | May 6 | United International Pictures | false |
| 11 | OceanWorld | - | - | - | $11,782 | 1 | $34,786 | Apr 8 | - | false |
| 12 | Nanny McPhee Returns | - | - | - | $11,701 | 5 | $15,298 | May 13 | United International Pictures | false |
| 13 | Alice in Wonderland | - | - | - | $10,990 | 6 | $212,062 | Mar 4 | Walt Disney Pictures | false |
| 14 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $8,154 | 1 | $18,933 | Apr 29 | - | false |
| 15 | Avatar | - | - | - | $7,045 | 14 | $2,515,341 | Dec 17 | 20th Century Fox International | false |
| 16 | Shutter Island | - | - | - | $6,987 | 4 | $105,693 | Mar 11 | United International Pictures | false |
| 17 | Besa | - | - | - | $6,236 | 5 | $40,563 | Apr 1 | - | false |
| 18 | When in Rome | - | - | - | $5,646 | 3 | $32,204 | Apr 8 | United International Pictures | false |
| 19 | From Paris with Love | - | - | - | $2,670 | 5 | $10,945 | Apr 15 | - | false |
| 20 | The Book of Eli | - | - | - | $2,443 | 6 | $40,582 | Mar 18 | Sony Pictures Releasing | false |
| 21 | My Bloody Valentine | - | - | - | $2,254 | 3 | $2,254 | May 6 | - | false |
| 22 | Fish Tank | - | - | - | $2,143 | 1 | $11,687 | May 6 | - | false |
| 23 | Toy Story 2 2009 Re-release | - | - | - | $1,760 | 3 | $8,642 | Apr 1 | Walt Disney Pictures | false |
| 24 | Legion | - | - | - | $1,676 | 5 | $15,096 | Apr 1 | Sony Pictures Releasing | false |
| 25 | The Princess and the Frog | - | - | - | $1,632 | 6 | $74,148 | Jan 28 | Walt Disney Pictures | false |
| 26 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $1,616 | 7 | $66,312 | Jan 14 | 20th Century Fox International | false |
| 27 | Brothers | - | - | - | $1,190 | 3 | $9,564 | Apr 15 | - | false |
| 28 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,073 | 7 | $44,454 | Feb 25 | 20th Century Fox International | false |
| 29 | Edge of Darkness | - | - | - | $1,056 | 5 | $24,808 | Mar 25 | - | false |
| 30 | The Hurt Locker | - | - | - | $950 | 1 | $5,438 | Apr 15 | - | false |
| 31 | The Rebound | - | - | - | $934 | 5 | $25,827 | Mar 25 | - | false |
| 32 | Coco Chanel & Igor Stravinsky | - | - | - | $679 | 2 | $17,734 | Mar 4 | - | false |
| 33 | Valentine's Day | - | - | - | $633 | 6 | $131,583 | Feb 11 | Warner Bros. | false |
| 34 | Invictus 2010 Re-release | - | - | - | $501 | 4 | $26,096 | Mar 4 | Warner Bros. | false |
| 35 | Arthur and the Revenge of Maltazard | - | - | - | $482 | 6 | $67,334 | Dec 31 | - | false |
| 36 | The Men Who Stare at Goats | - | - | - | $472 | 4 | $28,811 | Mar 11 | - | false |
| 37 | The Imaginarium of Doctor Parnassus | - | - | - | $329 | 2 | $40,269 | Feb 11 | - | false |
| 38 | Daybreakers | - | - | - | $313 | 5 | $3,523 | Mar 11 | - | false |
| 39 | The Wolfman | - | - | - | $295 | 6 | $89,919 | Feb 25 | United International Pictures | false |
| 40 | A Serious Man | - | - | - | $274 | 1 | $15,937 | Mar 25 | - | false |
| 41 | Away We Go | - | - | - | $225 | 1 | $3,694 | Apr 15 | - | false |
| 42 | Pope Joan | - | - | - | $106 | 2 | $9,871 | Mar 4 | - | false |
| 43 | Life During Wartime | - | - | - | $23 | 1 | $2,916 | Apr 8 | - | false |
